Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients

PURPOSE: Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. METHODS: Na concentration of this whole tumor area was compared between IDH-mutated and IDH wild-type gliomas as well as MGMT methylated and MGMT not-methylated glioblastomas using Whitney-Mann U-tests. All p-values were corrected after the Bonferroni-Holm procedure. RESULTS: Na concentration in MGMT methylated tumors that did not reach statistical significance (median [interquartile range]: MGMT methylated = 57.59 mM [50.70 - 59.17 mM], MGMT not methylated = 48.78 mM [45.88 - 53.91 mM], p = 1.0). CONCLUSIONS: Na concentration from central necrosis to normal-appearing white matter suggests a correlation with tumor infiltration.

Authors

• Sebastian Regnery
• Nicolas G.R. Behl
• Tanja Platt
• Nina Weinfurtner
• Paul Windisch
• Katerina Deike-Hofmann
• Felix Sahm
• Martin Bendszus
• Jürgen Debus
• Mark E. Ladd
• Heinz-Peter Schlemmer
• Stefan Rieken
• Sebastian Adeberg
• Daniel Paech

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