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Daniel Paech

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2 papers
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2

YNICL Journal 2020 Journal Article

Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients

  • Sebastian Regnery
  • Nicolas G.R. Behl
  • Tanja Platt
  • Nina Weinfurtner
  • Paul Windisch
  • Katerina Deike-Hofmann
  • Felix Sahm
  • Martin Bendszus

PURPOSE: Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. METHODS: Na concentration of this whole tumor area was compared between IDH-mutated and IDH wild-type gliomas as well as MGMT methylated and MGMT not-methylated glioblastomas using Whitney-Mann U-tests. All p-values were corrected after the Bonferroni-Holm procedure. RESULTS: Na concentration in MGMT methylated tumors that did not reach statistical significance (median [interquartile range]: MGMT methylated = 57.59 mM [50.70 - 59.17 mM], MGMT not methylated = 48.78 mM [45.88 - 53.91 mM], p = 1.0). CONCLUSIONS: Na concentration from central necrosis to normal-appearing white matter suggests a correlation with tumor infiltration.

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YNIMG Journal 2015 Journal Article

Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma

  • Moritz Zaiss
  • Johannes Windschuh
  • Daniel Paech
  • Jan-Eric Meissner
  • Sina Burth
  • Benjamin Schmitt
  • Philip Kickingereder
  • Benedikt Wiestler

Endogenous chemical exchange saturation transfer (CEST) effects of protons resonating near to water protons are always diluted by competing effects such as direct water saturation and semi-solid magnetization transfer (MT). This leads to unwanted T2 and MT signal contributions that contaminate the observed CEST signal. Furthermore, all CEST effects appear to be scaled by the T1 relaxation time of the mediating water pool. As MT, T1 and T2 are also altered in tumor regions, a recently published correction algorithm yielding the apparent exchange-dependent relaxation AREX, is used to evaluate in vivo CEST effects. This study focuses on CEST effects of amides (3. 5ppm) and Nuclear-Overhauser-mediated saturation transfer (NOE, −3. 5ppm) that can be properly isolated at 7T. These were obtained in 10 glioblastoma patients, and this is the first comprehensive study where AREX is applied in human brain as well as in human glioblastoma. The correction of CEST effects alters the contrast significantly: after correction, the CEST effect of amides does not show significant contrast between contrast enhancing tumor regions and normal tissue, whereas NOE drops significantly in the tumor area. In addition, new features in the AREX contrasts are visible. This suggests that previous CEST approaches might not have shown pure CEST effects, but rather water relaxation shine-through effects. Our insights help to improve understanding of the CEST effect changes in tumors and correlations on a cellular and molecular level.

Details DOI
v2026.09.13