Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

C-PiB correlated with GMR in posterior regions. These findings suggest that, in mild AD, tau aggregation drives local neurodegeneration, whereas the relationships between Aβ and neurodegeneration are not region specific and may be mediated by the interaction between Aβ and tau.

Authors

• Leonardo Iaccarino
• Gautam Tammewar
• Nagehan Ayakta
• Suzanne L. Baker
• Alexandre Bejanin
• Adam L. Boxer
• Maria Luisa Gorno-Tempini
• Mustafa Janabi
• Joel H. Kramer
• Andreas Lazaris
• Samuel N. Lockhart
• Bruce L. Miller
• Zachary A. Miller
• James P. O'Neil
• Rik Ossenkoppele
• Howard J. Rosen
• Daniel R. Schonhaut
• William J. Jagust
• Gil D. Rabinovici

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