YNICL Journal 2019 Journal Article
Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
- Rik Ossenkoppele
- Leonardo Iaccarino
- Daniel R. Schonhaut
- Jesse A. Brown
- Renaud La Joie
- James P. O'Neil
- Mustafa Janabi
- Suzanne L. Baker
F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32-0.78, p < .001), which corresponded with expected functional networks (range goodness-of-fit: 3.8-8.2). The topography of amyloid-β covariance patterns was more diffuse and less network-specific, while glucose hypometabolic patterns were more spatially restricted than tau but overlapped with functional networks. These findings suggest that the spatial patterns of tau and glucose hypometabolism observed in AD resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks and drives neurodegeneration.