Hippocampal [18F]flortaucipir BPND corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships

BACKGROUND: F]flortaucipir signal using a semi-automated technique, and assessed correlations with cognitive performance across methods. METHODS: VOIs and MMSE/delayed recall adjusted for age, sex and education. RESULTS: =-0.59[CI=-0.75-0.44]; all p<0.001), with comparable effect sizes for all hippocampal VOIs. CONCLUSIONS: and memory were comparable for all methods. The non-optimized 100% hippocampal VOI may be sufficient for clinical interpretation. However, proper correction for choroid plexus spillover and may be required in case of smaller effect sizes between subject groups or for longitudinal studies.

Authors

• Emma E Wolters
• Rik Ossenkoppele
• Sandeep SV Golla
• Sander CJ Verfaillie
• Tessa Timmers
• Denise Visser
• Hayel Tuncel
• Emma M Coomans
• Albert D Windhorst
• Philip Scheltens
• Wiesje M van der Flier
• Ronald Boellaard
• Bart NM van Berckel

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