YNICL Journal 2020 Journal Article
Hippocampal [18F]flortaucipir BPND corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships
- Emma E Wolters
- Rik Ossenkoppele
- Sandeep SV Golla
- Sander CJ Verfaillie
- Tessa Timmers
- Denise Visser
- Hayel Tuncel
- Emma M Coomans
BACKGROUND: F]flortaucipir signal using a semi-automated technique, and assessed correlations with cognitive performance across methods. METHODS: VOIs and MMSE/delayed recall adjusted for age, sex and education. RESULTS: =-0.59[CI=-0.75-0.44]; all p<0.001), with comparable effect sizes for all hippocampal VOIs. CONCLUSIONS: and memory were comparable for all methods. The non-optimized 100% hippocampal VOI may be sufficient for clinical interpretation. However, proper correction for choroid plexus spillover and may be required in case of smaller effect sizes between subject groups or for longitudinal studies.