Factoring the brain signatures of anesthesia concentration and level of arousal across individuals

Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.

Authors

• Pablo Barttfeld
• Tristan A. Bekinschtein
• Alejo Salles
• Emmanuel A. Stamatakis
• Ram Adapa
• David K. Menon
• Mariano Sigman

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