YNICL Journal 2015 Journal Article
Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
- Pablo Barttfeld
- Tristan A. Bekinschtein
- Alejo Salles
- Emmanuel A. Stamatakis
- Ram Adapa
- David K. Menon
- Mariano Sigman
Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.