Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study

Highlights • Aβ-PET predicts atrophy in key brain regions in older adults without dementia.• Fusiform volumetric loss is linked to Aβ independent of CSF tau levels.• Temporal atrophy is stronger in women with higher Aβ burden.• APOE-ε4 carriers show larger Aβ-driven frontal & hippocampal atrophy.

Authors

• Leonard Pieperhoff
• Luigi Lorenzini
• Sophie Mastenbroek
• Mario Tranfa
• Mahnaz Shekari
• Alle Meije Wink
• Robin Wolz
• Sylke Grootoonk
• Craig Ritchie
• Mercè Boada
• Marta Marquié
• Wiesje van der Flier
• Rik Vandenberghe
• Bernard J. Hanseeuw
• Pablo Martínez-Lage
• Pierre Payoux
• Pieter Jelle Visser
• Michael Schöll
• Giovanni B. Frisoni
• Andrew Stephens
• Christopher Buckley
• Gill Farrar
• Frank Jessen
• Oriol Grau-Rivera
• Juan Domingo Gispert
• David Vállez García
• Henk Mutsaerts
• Frederik Barkhof
• Lyduine E. Collij

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