YNICL Journal 2025 Journal Article
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
- Leonard Pieperhoff
- Luigi Lorenzini
- Sophie Mastenbroek
- Mario Tranfa
- Mahnaz Shekari
- Alle Meije Wink
- Robin Wolz
- Sylke Grootoonk
Highlights • Aβ-PET predicts atrophy in key brain regions in older adults without dementia.• Fusiform volumetric loss is linked to Aβ independent of CSF tau levels.• Temporal atrophy is stronger in women with higher Aβ burden.• APOE-ε4 carriers show larger Aβ-driven frontal & hippocampal atrophy.