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Fudong Lin

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3 papers

2 author rows

ICLR Conference 2025 Conference Paper

BoneMet: An Open Large-Scale Multi-Modal Murine Dataset for Breast Cancer Bone Metastasis Diagnosis and Prognosis

Tiankuo Chu
Fudong Lin
Shubo Wang
Jason Jiang
Wiley Jia-Wei Gong
Xu Yuan 0001
Liyun Wang

Breast cancer bone metastasis (BCBM) affects women’s health globally, calling for the development of effective diagnosis and prognosis solutions. While deep learning has exhibited impressive capacities across various healthcare domains, its applicability in BCBM diseases is consistently hindered by the lack of an open, large-scale, deep learning-ready dataset. As such, we introduce the Bone Metastasis (BoneMet) dataset, the first large-scale, publicly available, high-resolution medical resource, which is derived from a well-accepted murine BCBM model. The unique advantage of BoneMet over existing human datasets is repeated sequential scans per subject over the entire disease development phases. The dataset consists of over 67 terabytes of multi-modal medical data, including 2D X-ray images, 3D CT scans, and detailed biological data (e.g., medical records and bone quantitative analysis), collected from more than five hundreds mice spanning from 2019 to 2024. Our BoneMet dataset is well-organized into six components, i.e., Rotation X-Ray, Recon-CT, Seg-CT, Regist-CT, RoI-CT, and MiceMediRec. We further show that BoneMet can be readily adopted to build versatile, large-scale AI models for managing BCBM diseases in terms of diagnosis using 2D or 3D images, prognosis of bone deterioration, and sparse-angle 3D reconstruction for safe long-term disease monitoring. Our preliminary results demonstrate that BoneMet has the potentials to jump-start the development and fine-tuning of AI-driven solutions prior to their applications to human patients. To facilitate its easy access and wide dissemination, we have created the BoneMet package, providing three APIs that enable researchers to (i) flexibly process and download the BoneMet data filtered by specific time frames; and (ii) develop and train large-scale AI models for precise BCBM diagnosis and prognosis. The BoneMet dataset is officially available on Hugging Face Datasets at https://huggingface.co/datasets/BoneMet/BoneMet. The BoneMet package is available on the Python Package Index (PyPI) at https://pypi.org/project/BoneMet. Code and tutorials are available at https://github.com/Tiankuo528/BoneMet.

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NeurIPS Conference 2025 Conference Paper

Long-Tailed Recognition via Information-Preservable Two-Stage Learning

Fudong Lin
Xu Yuan

The imbalance (or long-tail) is the nature of many real-world data distributions, which often induces the undesirable bias of deep classification models toward frequent classes, resulting in poor performance for tail classes. In this paper, we propose a novel two-stage learning approach to mitigate such a majority-biased tendency while preserving valuable information within datasets. Specifically, the first stage proposes a new representation learning technique from the information theory perspective. This approach is theoretically equivalent to minimizing intra-class distance, yielding an effective and well-separated feature space. The second stage develops a novel sampling strategy that selects mathematically informative instances, able to rectify majority-biased decision boundaries without compromising a model’s overall performance. As a result, our approach achieves the state-of-the-art performance across various long-tailed benchmark datasets, validated via extensive experiments. Our code is available at https: //github. com/fudong03/BNS_IPDPP.

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IJCAI Conference 2021 Conference Paper

Interpretable Minority Synthesis for Imbalanced Classification

Yi He
Fudong Lin
Xu Yuan
Nian-Feng Tzeng

This paper proposes a novel oversampling approach that strives to balance the class priors with a considerably imbalanced data distribution of high dimensionality. The crux of our approach lies in learning interpretable latent representations that can model the synthetic mechanism of the minority samples by using a generative adversarial network(GAN). A Bayesian regularizer is imposed to guide the GAN to extract a set of salient features that are either disentangled or intensionally entangled, with their interplay controlled by a prescribed structure, defined with human-in-the-loop. As such, our GAN enjoys an improved sample complexity, being able to synthesize high-quality minority samples even if the sizes of minority classes are extremely small during training. Empirical studies substantiate that our approach can empower simple classifiers to achieve superior imbalanced classification performance over the state-of-the-art competitors and is robust across various imbalance settings. Code is released in github. com/fudonglin/IMSIC.

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