Unified segmentation

A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a log-likelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and is extended to incorporate a smooth intensity variation and nonlinear registration with tissue probability maps. A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function.

Authors

• John Ashburner
• Karl J. Friston

Keywords

• Image registration
• Tissue classification
• Bias correction
• Mixture of Gaussians
• Tissue probability maps