The connection of motor improvement after deep brain stimulation in Parkinson’s disease and microstructural integrity of the substantia nigra and subthalamic nucleus

BACKGROUND: Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson's disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging. METHODS: and records of motor improvement available. RESULTS: The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. However, this did not reach significance after Bonferroni correction and controlling for sex and age. CONCLUSION: Microstructural integrity of SN and STN are potential biomarkers for the prediction of therapy efficacy following STN-DBS, but further studies are required to confirm these associations.

Authors

• Marco G. Hermann
• Nils Schröter
• Alexander Rau
• Marco Reisert
• Nadja Jarc
• Michel Rijntjes
• Jonas A. Hosp
• Peter C. Reinacher
• Wolfgang H. Jost
• Horst Urbach
• Cornelius Weiller
• Volker A. Coenen
• Bastian E.A. Sajonz

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