Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?

C-Pittsburgh compound B (PiB) Aβ-PET to predict cognitive decline. A cohort of 153 participants who previously underwent PiB-PET scans and comprehensive clinical assessments were used in this study. Our analyses revealed that baseline Aβ is significantly associated with the rate of change in cognitive composite scores, with cognition declining more rapidly when baseline PiB Aβ levels were higher. In contrast, no signification association was identified between the rate of change in PiB-PET Aβ and cognitive decline. Additionally, the ability of the rate of change in the PiB-PET measures to predict cognitive decline was significantly influenced by APOE ε4 carrier status. These results suggest that a single PiB-PET scan is sufficient to predict cognitive decline and that longitudinal measures of Aβ accumulation do not improve the prediction of cognitive decline once someone is amyloid positive.

Authors

• Gengsheng Chen
• Nicole S. McKay
• Brian A. Gordon
• Jingxia Liu
• Nelly Joseph-Mathurin
• Suzanne E. Schindler
• Jason Hassenstab
• Andrew J. Aschenbrenner
• Qing Wang
• Stephanie A. Schultz
• Yi Su
• Pamela J LaMontagne
• Sarah J. Keefe
• Parinaz Massoumzadeh
• Carlos Cruchaga
• Chengjie Xiong
• John C. Morris
• Tammie L.S. Benzinger

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