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JBHI 2026

Adversarial and Correlation-Aware Data Augmentation Framework for Multi-Label Chest X-Ray Image Classification

Journal Article journal-article Artificial Intelligence ยท Biomedical and Health Informatics

Abstract

Deep learning-based methods have shown promising results in multi-label chest X-ray (CXR) image classification. However, most existing methods rely on large-scale fully-annotated datasets, which are costly and laborious to obtain. Therefore, training a high-performance model with limited annotation remains a significant challenge in practice. To address this issue, we propose an Adversarial and Correlation-Aware Data Augmentation (ACAA) framework for multi-label CXR image classification. First, we generate pseudo labels based on the model predictions on weakly-augmented images. Next, we propose a Generalized Nesterov Iterative Fast Gradient Sign Method (GNI-FGSM) to generate effective adversarial examples as image-level strongly-augmented data. Then, we introduce an image-level adversarial-augmentation-based consistency regularization to perform supervision of model predictions on the above image-level adversarial examples. To explore more diverse data transformations, we further perform adversarial augmentation in the feature space by imposing perturbations on the extracted features of each image and introduce a feature-level adversarialaugmentation- based consistency regularization. Furthermore, we propose a Batch-level Mamba module (Batch- Mamba) coupled with a batch-level Mamba-based correlation regularization to explore inter-sample correlations along batch dimension. Extensive experiments on two large CXR datasets (CheXpert and MIMIC-CXR) demonstrate the effectiveness of the proposed ACAA framework for multilabel CXR image classification under limited-annotation scenario.

Authors

Keywords

  • Data augmentation
  • Feature extraction
  • Training
  • Correlation
  • Image classification
  • Predictive models
  • Pathology
  • Iterative methods
  • X-ray imaging
  • Transformers
  • Chest X-ray
  • Classification Framework
  • Chest X-ray Images
  • Augmented Framework
  • Adversarial Data
  • Classification Of X-ray Images
  • Chest X-ray Image Classification
  • Data Augmentation Framework
  • Adversarial Data Augmentation
  • Multi-label Chest X-ray
  • Prediction Model
  • Feature Space
  • Fast Method
  • Deep Learning-based Methods
  • Pseudo Labels
  • Adversarial Examples
  • Consistency Regularization
  • Fast Gradient Sign Method
  • Adversarial Perturbations
  • Batch Of Images
  • Image X
  • Regularization Loss
  • Semi-supervised Learning
  • Patient-Centered Outcomes Research Institute
  • Augmentation Strategy
  • Medical Image Analysis
  • Classification Performance
  • Positive Labels
  • Multi-label chest X-ray image classification
  • Mamba

Context

Venue
IEEE Journal of Biomedical and Health Informatics
Archive span
2013-2026
Indexed papers
6337
Paper id
1001423002362851627
v2026.09.13