EAAI Journal 2025 Journal Article
Adaptive Deformable Convolutional Neural Network Framework for depression-related behavioral analysis in mice
- Jian Li
- Ziyi Li
- Peng Shan
- Xiaoyong Lyu
- Yu Tian
- Chen Du
- Ying Wang
- Yuliang Zhao
The use of approximately 1 billion laboratory animals annually in research highlights the urgent need for advanced methods to analyze behavioral dynamics, particularly in mice. Capturing subtle and prolonged behavioral changes, such as those observed in long-term depression studies, poses a significant challenge. To address this, we propose an Adaptive Deformable Convolutional Neural Network Framework for depression-related behavioral analysis in mice. By integrating DeepLabCut (DLC) with deformable convolutional networks (DCN) and convolutional block attention module (CBAM), the framework captures subtle and prolonged behavioral changes with high precision. Adaptive image deformation encodes joint movements into image representations, enabling robust analysis of spatial and temporal patterns. In depression modeling experiment, the framework achieved over 80% classification accuracy, demonstrating its scalability and efficiency. This non-invasive, automated solution represents a transformative advancement in behavioral analysis, offering a reliable tool for long-term studies in animal models.