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Zhengxia Wang

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AAAI Conference 2026 Conference Paper

Graph-Semantic Guided Learning for Virtual Immunohistochemistry Staining on Consecutive Histology Sections

Fanhao Qiu
Yangyang Zhang
Zhengxia Wang

Virtual Immunohistochemistry (IHC) staining technology employs generative models to directly synthesize IHC images from Hematoxylin and Eosin (H&E) images, reducing reliance on chemical staining while improving diagnostic efficiency and reducing costs. However, existing virtual staining methods relying on adjacent sections face two critical challenges: insufficient mining of pathological semantics and the spatial misalignment of pathological semantics due to physical discrepancies between sections. To address these, we propose GSGStain, a Graph-Semantic Guided Learning for virtual Staining. Our method innovatively transforms the problem from pixel space to graph space, enabling semantic noise correction for spatial misalignment features. Specifically, to capture the rich pathological semantics, we construct a cell graph from the H&E image to encode tissue architecture, annotating nodes with noisy biomarker semantic features derived from misaligned adjacent IHC sections. Furthermore, to correct for the semantic misalignment, a Graph Semantic Rectification Module (GSRM) then refines these features using graph contextual reasoning, while a Graph Semantic Consistency Loss ensures alignment between generated IHC images and rectified semantics. Additionally, we propose a dual-branch discriminator to compel the generator to match the empirical distribution of real images, significantly improving generation quality. Extensive experiments on two public benchmarks demonstrate that GSGStain significantly outperforms state-of-the-art methods in both image quality and pathological consistency. This work establishes a new paradigm for semantically robust virtual staining.

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JBHI Journal 2019 Journal Article

Functional Brain Network Estimation With Time Series Self-Scrubbing

Weikai Li
Lishan Qiao
Limei Zhang
Zhengxia Wang
Dinggang Shen

Functional brain network (FBN) is becoming an increasingly important measurement for exploring cerebral mechanisms and mining informative biomarkers that assist diagnosis of some neurodegenerative disorders. Despite its effectiveness to discover valuable hidden patterns in the human brain, the estimated FBNs are often heavily influenced by the quality of the observed data (e. g. , blood oxygen level dependent signal series). In practice, a preprocessing pipeline is usually employed for improving data quality. With this in mind, some data points (volumes or time course in the time series) are still not clean enough, due to artifacts including spurious resting-state processes (head movement, mind-wandering). Therefore, not all volumes in the fMRI time series can contribute to the subsequent FBN estimation. To address this issue, we propose a novel FBN estimation method by introducing a latent variable as an indicator of the data quality, and develop an alternating optimization algorithm for jointly scrubbing the data and estimating FBN simultaneously. To further illustrate the effectiveness of the proposed method, we conduct experiments on two public datasets to identify subjects with mild cognitive impairment from normal controls based on the estimated FBNs, and achieve improved accuracies than the baseline methods.

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