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Yumin Chen

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EAAI Journal 2026 Journal Article

Fuzzy granule kernel density estimation for outlier detection

  • Shiwang Zhang
  • Yumin Chen
  • Can Gao
  • Jie Zhou
  • Yiting Lin

Outlier detection is a fundamental task in data mining for identifying rare instances that deviate from the norm. Its effectiveness is often hindered by datasets containing a heterogeneous mix of attributes, which introduce substantial uncertainty and blur the boundaries between concepts. Traditional detection methods that rely on crisp distance or density metrics struggle in such settings. Fuzzy rough set (FRS) theory, by leveraging information granulation to explicitly model this uncertainty, is particularly well suited to address these challenges. Nevertheless, existing FRS-based approaches exhibit a notable limitation as they primarily capture the relational structure among samples while often overlooking the informative role of local density distributions, thereby reducing their ability to detect subtle, locally sparse outliers. To bridge this gap, we propose fuzzy granule kernel density estimation for outlier detection (FGDOD), a novel algorithm that integrates fuzzy-granule representation with kernel density estimation in a unified framework. By employing a hybrid fuzzy similarity relation with an adaptive radius, FGDOD first constructs robust fuzzy granules for heterogeneous data. A kernel-based density quantification is then used to characterize the local distributional properties of these granules, and a density-weighted fusion strategy aggregates multi-granularity information to produce more discriminative outlier scores. Extensive experiments on 20 benchmark datasets demonstrate that FGDOD consistently outperforms mainstream detection algorithms, demonstrating superior effectiveness, robustness, and generalization capability across heterogeneous data types.

YNIMG Journal 2025 Journal Article

Anatomical heterogeneity in low-grade and high-grade gliomas: A multiscale perspective

  • Shengpeng Liang
  • Nuo Dong
  • Yumin Chen
  • Yang Yang
  • Haibing Xu

BACKGROUND: Low-grade gliomas (LGGs) and high-grade gliomas (HGGs) often exhibit distinct spatial distributions, a phenomenon that remains incompletely understood. Based on previous research, we hypothesized that functional networks, neurotransmitters, and isocitrate dehydrogenase-1 (IDH-1) status characterize the spatial patterns of LGG and HGG. METHODS: We analyzed 399 patients diagnosed with primary gliomas. First, we generated glioma frequency maps based on tumor grade, neurotransmitters, and IDH-1 status and constructed a brain functional connectivity network to explore heterogeneity in glioma location. Second, all tumor masks were mirror-symmetrized onto the brain's left hemisphere to facilitate feature extraction. We performed independent component analysis on merged four-dimensional files using Multivariate Exploratory Linear Optimized Decomposition into Independent Component (MELODIC), identifying four IDH-1 wild-type lesion covariance networks (IDHwt-LCNs) and three IDH-1 mutant lesion covariance networks (IDHmut-LCNs) with distinct spatial distributions, and analyzing correlation between the neurotransmitter levels and the IDH-wt/mut specific LCNs. Finally, we compared 42 white matter fibers extracted using XTRACT with 39 functional brain connectivity networks from the multi-subject dictionary learning (MSDL) atlas, revealing significant associations among the frontal aslant tract (FAT) and the intraparietal sulcus (IPS). RESULTS: Our findings revealed high anatomical heterogeneity between LGG and HGG. Moreover, the high node strength played a critical role in the distinct spatial distribution of glioma. Significant correlations were observed between glioma frequency maps and dopaminergic, cholinergic, μ-opioid, and serotonergic neurotransmission. Furthermore, IDHwt/mut-LCNs analysis demonstrated that IDH-1 status influences glioma distribution, involving key brain structures. Lastly, we also found significant correlations between IDHwt/mut-LCNs and the neurotransmission of dopaminergic, cholinergic, μ-opioid, and serotonergic systems. CONCLUSION: Our study highlighted the mechanisms by which functional networks, neurotransmitter systems, and IDH-1 status collectively contribute to the anatomical heterogeneity observed in LGG and HGG.

v2026.09.13