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Yujie Guo

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AAAI Conference 2026 Conference Paper

DIFFA: Large Language Diffusion Models Can Listen and Understand

  • Jiaming Zhou
  • Hongjie Chen
  • Shiwan Zhao
  • Jian Kang
  • Jie Li
  • Enzhi Wang
  • Yujie Guo
  • Haoqin Sun

Recent advances in large language models (LLMs) have shown remarkable capabilities across textual and multimodal domains. In parallel, large language diffusion models have emerged as a promising alternative to the autoregressive paradigm, offering improved controllability, bidirectional context modeling, and robust generation. However, their application to the audio modality remains underexplored. In this work, we introduce DIFFA, the first diffusion-based large audio-language model designed to perform spoken language understanding. DIFFA integrates a frozen diffusion language model with a lightweight dual-adapter architecture that bridges speech understanding and natural language reasoning. We employ a two-stage training pipeline: first, aligning semantic representations via an ASR objective; then, learning instruction-following abilities through synthetic audio-caption pairs automatically generated by prompting LLMs. Despite being trained on only 960 hours of ASR and 127 hours of synthetic instruction data, DIFFA demonstrates competitive performance on major benchmarks, including MMSU, MMAU, and VoiceBench, outperforming several autoregressive open-source baselines. Our results reveal the potential of large language diffusion models for efficient and scalable audio understanding, opening a new direction for speech-driven AI.

YNICL Journal 2022 Journal Article

The effect of time delay for magnetic resonance contrast-enhanced scan on imaging for small-volume brain metastases

  • Mingming Chen
  • Pengcheng Wang
  • Yujie Guo
  • Yong Yin
  • Lizhen Wang
  • Ya Su
  • Guanzhong Gong

PURPOSE: To study the effect of different enhancement timings of magnetic resonance (MR) on small-volume brain metastases (BM) visualisation and provide a basis for the contour of tumour targets. METHOD: We prospectively enrolled 101 patients with BM who received radiotherapy. All patients underwent computed tomography (CT) and MR simulations. Contrast-enhanced MR scans at 1, 3, 5, 10, 18, and 20 min after injection of contrast medium were performed. The tumour target was determined on MR images at different enhancement times, and the differences of tumour target volume, maximum diameter, and MR signal intensity were compared. RESULTS: , respectively. Compared to 1 min, BM volume at other times increased by 13.1 %, 21.5 %, 31.6 %, 39.6 %, and 41.7 %, and the difference between the maximum and minimum volumes was statistically significant (p 10 min is essential.

v2026.09.13