EAAI Journal 2026 Journal Article
A Local-Global Fusion Vision Mamba UNet Framework for medical image segmentation
- Yanbo Li
- Zihan Mao
- Feiwei Qin
- Yong Peng
- Guodao Zhang
- Xugang Xi
- Xiaoqin Ma
- Huanhuan Yu
As a State Space Model (SSM) that achieves long-range dependency modeling with linear computational complexity, Mamba demonstrates significant efficiency advantages in medical image segmentation. However, while Mamba-based methods enable long-range modeling with linear complexity, their global dependency mechanisms often lead to local feature attenuation, particularly affecting the processing of complex anatomical structures. Existing multi-scale fusion methods also exhibit limited compatibility with State Space Models. To address these challenges, this paper proposes the Local-Global Fusion Vision Mamba UNet (LGFVM-UNet) framework. Its core innovation lies in the Dynamic Gating-enhanced Local-Global Fusion Visual State Space (LGF-VSS) block, which enables the synergistic modeling of global context and local details. Additionally, we designed a Multi-level Cross-scale Feature Fusion Block (MCFB) that enhances multi-scale feature representation through bidirectional resampling and spatial-channel dual attention mechanisms. Additionally, we propose a Gradient Statistics-based Adaptive Hierarchical Loss that dynamically adjusts multi-level supervision weights to optimize the learning process. The proposed method is experimentally validated on five public medical image segmentation datasets spanning diverse imaging modalities and anatomical structures. Results demonstrate that our approach outperforms state-of-the-art methods, excelling in long-range dependency modeling, local detail capture, and multi-scale feature fusion. The source code of our work is available at https: //github. com/NicoleDyson/LGFVM-UNet.