EAAI Journal 2026 Journal Article
A self-supervised visual auto-regressive framework for medical hyperspectral anomaly detection
- Lingqin Chen
- Jinzhuang Xu
- Yu Jiang
- Zhihao Zhan
- Xiaoli Yang
- Mingzhong Pan
- Chenglong Zhang
- Xuesen Xu
Medical hyperspectral imaging non-invasively acquires tissue spatial–spectral information, holding promise for early diagnosis, real-time and precision treatment. However, complex tissue properties and dependence on labeled data challenge lesion identification. Hyperspectral anomaly detection, widely applied for its unsupervised capability and sensitivity to anomalies, is promising to identify unknown lesions without requiring labels. Nevertheless, current hyperspectral anomaly detection methods often underperform in medical hyperspectral images due to misalignment with biological tissue structures, inadequate use of spectral features, and noise sensitivity. Therefore, we propose a self-supervised framework based on visual auto-regressive modeling for medical hyperspectral anomaly detection. We introduce the multi-scale generation paradigm of visual auto-regressive modeling for the first time to accommodate the structure of biological tissues. Second, we employ the graph convolutional network to optimize spectral features. A multi-scale fusion module improves feature integration and robustness. Finally, enhanced separated training refines the reconstruction with spatial context. Our method effectively leverages spectral–spatial features, enabling robust background reconstruction and accurate anomaly detection. Experiments on medical hyperspectral imaging datasets show that it outperforms state-of-the-art methods, with strong noise robustness and generalization, which demonstrating high clinical potential.