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Yanyu Chen

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AAAI Conference 2026 Conference Paper

A Principle-Driven Adaptive Policy for Group Cognitive Stimulation Dialogue for Elderly with Cognitive Impairment

  • Jiyue Jiang
  • Yanyu Chen
  • Pengan CHEN
  • Kai Liu
  • Jingqi Zhou
  • Zheyong Zhu
  • He Hu
  • Fei Ma

Cognitive impairment is becoming a major public health challenge. Cognitive Stimulation Therapy (CST) is an effective intervention for cognitive impairment, but traditional methods are difficult to scale, and existing digital systems struggle with group dialogues and cognitive stimulation principles. While Large Language Models (LLMs) are powerful, their application in this context faces key challenges: cognitive stimulation dialogue paradigms, a lack of therapeutic reasoning, and static-only user modeling. To address these issues, we propose a principle-driven adaptive policy actualized through a Group Cognitive Stimulation Dialogue (GCSD) system. We first construct a dataset with over 500 hours of real-world CST conversations and 10,000+ simulated dialogues generated via our Principle-Guided Scenario Simulation strategy. Our GCSD system then integrates four core modules to overcome LLM limitations: (i) a multi-speaker context controller to resolve role confusion; (ii) dynamic participant cognitive state modeling for personalized interaction; (iii) a cognitive stimulation-focused attention loss to instill cognitive stimulation reasoning; and (iv) a multi-dimensional reward strategy to enhance response value. Experimental results demonstrate that GCSD significantly outperforms baseline models across various evaluation metrics. Future work will focus on long-term clinical validation to bridge the gap between computational performance and clinical efficacy.

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AAAI Conference 2026 Conference Paper

DS-ProGen: A Dual-Structure Deep Language Model for Functional Protein Design

  • Yanting Li
  • Zikang Wang
  • Jiyue Jiang
  • Ziqian Lin
  • Dongchen He
  • Yuheng Shan
  • Yanruisheng Shao
  • Jiayi Li

Inverse Protein Folding (IPF) is a critical subtask in the field of protein design, aiming to engineer amino acid sequences capable of folding correctly into a specified three-dimensional (3D) conformation. Although substantial progress has been achieved in recent years, existing methods generally rely on either backbone coordinates or molecular surface features alone, which restricts their ability to fully capture the complex chemical and geometric constraints necessary for precise sequence prediction. To address this limitation, we present DS-ProGen, a dual-structure deep language model for functional protein design, which integrates both backbone geometry and surface-level representations. By incorporating backbone coordinates as well as surface chemical and geometric descriptors into a next-amino-acid prediction paradigm, DS-ProGen is able to generate functionally relevant and structurally stable sequences while satisfying both global and local conformational constraints. On the PRIDE dataset, DS-ProGen attains the current state-of-the-art recovery rate of 61.47%, demonstrating the synergistic advantage of multi-modal structural encoding in protein design. Furthermore, DS-ProGen excels in predicting interactions with a variety of biological partners, including ligands, ions, and RNA, confirming its robust functional retention capabilities.

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AAAI Conference 2026 Conference Paper

RMSAGen: Integrating Multiple Sequence Alignment for Function RNA Design

  • Jiyue Jiang
  • Yanyu Chen
  • Qingchuan Zhang
  • Jiayi Li
  • Xiangyu Shi
  • Chang Zhou
  • Ziqian Lin
  • Jiuming Wang

Biological sequences, including RNAs and proteins, share similarities with natural languages, enabling the application of advanced language models to various biological tasks. However, due to its flexibility and lack of experimental data, RNA is a particularly challenging biological ``language'' compared to other biological sequences like proteins. RNA multiple sequence alignments (MSAs), which align evolutionarily related RNA sequences, can greatly enhance RNA biology modeling, as evidenced by their significant roles in structure prediction and function annotation. This raises the question of whether RNA MSAs can also benefit RNA design, which remains unexplored. This paper introduces RMSAGen, a model comprising RMSA-Encoder and RMSA-Decoder, that leverages MSAs to design functional RNA sequences. RMSA-Encoder effectively extracts MSA features, enhancing performance in functional prediction and solvent accessibility prediction tasks and supporting RMSA-Decoder in accurate RNA generation. RMSAGen can design RNA sequences that effectively bind to target RNA-binding proteins, and the design performance improves with an increasing number of sequences. In addition, the ribozymes designed with structural features by RMSAGen show strong computational metrics and exhibit biological activity during gel electrophoresis. These results highlight the effectiveness of RMSAGen, establishing it as a powerful tool and a new direction for RNA design.

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