Arrow Research search

Author name cluster

Yan Bai

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

9 papers
1 author row

Possible papers

9

YNICL Journal 2026 Journal Article

Natural progression of glioma enhances functional connection with the cerebral cortex through synaptogenesis

  • Jiacheng Lai
  • Yan Bai
  • Hongbo Bao
  • Shuai Wu
  • Xinyu Wang
  • Xia Liang
  • Peng Liang

OBJECTIVES: Understanding the progression mechanisms of glioma holds significant implications for improving clinical management. However, the natural progression patterns of glioma remain poorly understood due to the lack of longitudinal clinical samples from untreated patients. MATERIALS AND METHODS: In this study, we systematically explored the natural progression trajectory of glioma by combining functional magnetic resonance imaging (fMRI) analysis of 24 rare multifocal glioma patients with bioinformatic analysis of single-cell RNA sequencing (scRNA-seq) data obtained from tumor samples of glioma mouse with early, mid, and endpoint lesions. RESULTS: We discovered that larger tumors in multifocal gliomas exhibit stronger functional connectivity with the cerebral cortex and higher degree centrality within brain networks. ScRNA-seq of longitudinal mouse glioma samples revealed progressive activation of synaptic organization and associated regulatory pathways during the natural progression of glioma. CONCLUSION: Our multimodal, cross-scale study demonstrates that the natural progression pattern of glioma macroscopically manifests as functional hyperconnectivity with the cerebral cortex, which is supported by microscale molecular programs driving synaptogenesis. These findings elucidate the characteristics and mechanisms underlying glioma natural progression.

Details DOI

YNIMG Journal 2025 Journal Article

Individualized functional connectivity markers for motor and mood symptoms of Parkinson’s disease

  • Louisa Dahmani
  • Yan Bai
  • Wei Zhang
  • Jianxun Ren
  • Shiyi Li
  • Qingyu Hu
  • Xiaoxuan Fu
  • Jianjun Ma

Parkinson's disease (PD) is a complex neurological disorder characterized by many motor and non-motor symptoms. While most studies focus on the motor symptoms of the disease, it is important to identify pathophysiological markers that underlie different facets of the disease. In this case-control study, we sought to discover reliable, individualized functional connectivity markers associated with both motor and mood symptoms of PD. In order to obtain precise functional connectivity measurements, we extensively sampled 166 patients with PD and 51 healthy control participants using functional MRI and characterized functional connectomes at the level of each individual participant. Multiple linear regressions were performed to model the relationship between functional connectivity markers and PD symptoms. We found that a model consisting of 44 functional connections predicted both motor (r = 0.21, p = 0.006) and mood symptoms (depression: r = 0.23, p = 0.006; anxiety: r = 0.21, p = 0.006). Two sets of connections contributed differentially to these predictions. Between-network connections, mainly connecting the sensorimotor and visual large-scale functional networks, substantially contributed to the prediction of motor measures, while within-network connections in the insula and sensorimotor network contributed more so to mood prediction. The middle to posterior insula region played a particularly important role in predicting depression and anxiety scores. We successfully replicated and generalized our findings in three independent PD datasets. Taken together, our findings indicate that sensorimotor and visual network markers are indicative of PD brain pathology, and that distinct subsets of markers are associated with motor and mood symptoms of PD.

Details DOI

AAAI Conference 2023 Conference Paper

Decorate the Newcomers: Visual Domain Prompt for Continual Test Time Adaptation

  • Yulu Gan
  • Yan Bai
  • Yihang Lou
  • Xianzheng Ma
  • Renrui Zhang
  • Nian Shi
  • Lin Luo

Continual Test-Time Adaptation (CTTA) aims to adapt the source model to continually changing unlabeled target domains without access to the source data. Existing methods mainly focus on model-based adaptation in a self-training manner, such as predicting pseudo labels for new domain datasets. Since pseudo labels are noisy and unreliable, these methods suffer from catastrophic forgetting and error accumulation when dealing with dynamic data distributions. Motivated by the prompt learning in NLP, in this paper, we propose to learn an image-layer visual domain prompt for target domains while having the source model parameters frozen. During testing, the changing target datasets can be adapted to the source model by reformulating the input data with the learned visual prompts. Specifically, we devise two types of prompts, i.e., domains-specific prompts and domains-agnostic prompts, to extract current domain knowledge and maintain the domain-shared knowledge in the continual adaptation. Furthermore, we design a homeostasis-based adaptation strategy to suppress domain-sensitive parameters in domain-invariant prompts to learn domain-shared knowledge more effectively. This transition from the model-dependent paradigm to the model-free one enables us to bypass the catastrophic forgetting and error accumulation problems. Experiments show that our proposed method achieves significant performance gains over state-of-the-art methods on four widely-used benchmarks, including CIFAR-10C, CIFAR-100C, ImageNet-C, and VLCS datasets.

PDF Details DOI

AAAI Conference 2022 Conference Paper

Neighborhood Consensus Contrastive Learning for Backward-Compatible Representation

  • Shengsen Wu
  • Liang Chen
  • Yihang Lou
  • Yan Bai
  • Tao Bai
  • Minghua Deng
  • Ling-Yu Duan

In object re-identification (ReID), the development of deep learning techniques often involves model updates and deployment. It is unbearable to re-embedding and re-index with the system suspended when deploying new models. Therefore, backward-compatible representation is proposed to enable “new” features to be compared with “old” features directly, which means that the database is active when there are both “new” and “old” features in it. Thus we can scroll-refresh the database or even do nothing on the database to update. The existing backward-compatible methods either require a strong overlap between old and new training data or simply conduct constraints at the instance level. Thus they are difficult in handling complicated cluster structures and are limited in eliminating the impact of outliers in old embeddings, resulting in a risk of damaging the discriminative capability of new features. In this work, we propose a Neighborhood Consensus Contrastive Learning (NCCL) method. With no assumptions about the new training data, we estimate the subcluster structures of old embeddings. A new embedding is constrained with multiple old embeddings in both embedding space and discrimination space at the sub-class level. The effect of outliers diminished, as the multiple samples serve as “mean teachers”. Besides, we propose a scheme to filter the old embeddings with low credibility, further improving the compatibility robustness. Our method ensures the compatibility without impairing the accuracy of the new model. It can even improve the new model’s accuracy in most scenarios.

PDF Details

JBHI Journal 2021 Journal Article

A Deep Learning Radiomics Model to Identify Poor Outcome in COVID-19 Patients With Underlying Health Conditions: A Multicenter Study

  • Siwen Wang
  • Di Dong
  • Liang Li
  • Hailin Li
  • Yan Bai
  • Yahua Hu
  • Yuanyi Huang
  • Xiangrong Yu

Objective: Coronavirus disease 2019 (COVID-19) has caused considerable morbidity and mortality, especially in patients with underlying health conditions. A precise prognostic tool to identify poor outcomes among such cases is desperately needed. Methods: Total 400 COVID-19 patients with underlying health conditions were retrospectively recruited from 4 centers, including 54 dead cases (labeled as poor outcomes) and 346 patients discharged or hospitalized for at least 7 days since initial CT scan. Patients were allocated to a training set (n = 271), a test set (n = 68), and an external test set (n = 61). We proposed an initial CT-derived hybrid model by combining a 3D-ResNet10 based deep learning model and a quantitative 3D radiomics model to predict the probability of COVID-19 patients reaching poor outcome. The model performance was assessed by area under the receiver operating characteristic curve (AUC), survival analysis, and subgroup analysis. Results: The hybrid model achieved AUCs of 0. 876 (95% confidence interval: 0. 752-0. 999) and 0. 864 (0. 766-0. 962) in test and external test sets, outperforming other models. The survival analysis verified the hybrid model as a significant risk factor for mortality (hazard ratio, 2. 049 [1. 462–2. 871], P P Conclusion: The hybrid model that combined deep learning and radiomics could accurately identify poor outcomes in COVID-19 patients with underlying health conditions from initial CT scans. The great risk stratification ability could help alert risk of death and allow for timely surveillance plans.

Details DOI

JBHI Journal 2020 Journal Article

A Deep Learning Prognosis Model Help Alert for COVID-19 Patients at High-Risk of Death: A Multi-Center Study

  • Lingwei Meng
  • Di Dong
  • Liang Li
  • Meng Niu
  • Yan Bai
  • Meiyun Wang
  • Xiaoming Qiu
  • Yunfei Zha

Since its outbreak in December 2019, the persistent coronavirus disease (COVID-19) became a global health emergency. It is imperative to develop a prognostic tool to identify high-risk patients and assist in the formulation of treatment plans. We retrospectively collected 366 severe or critical COVID-19 patients from four centers, including 70 patients who died within 14 days (labeled as high-risk patients) since their initial CT scan and 296 who survived more than 14 days or were cured (labeled as low-risk patients). We developed a 3D densely connected convolutional neural network (termed De-COVID19-Net) to predict the probability of COVID-19 patients belonging to the high-risk or low-risk group, combining CT and clinical information. The area under the curve (AUC) and other evaluation techniques were used to assess our model. The De-COVID19-Net yielded an AUC of 0. 952 (95% confidence interval, 0. 928-0. 977) on the training set and 0. 943 (0. 904-0. 981) on the test set. The stratified analyses indicated that our model's performance is independent of age, sex, and with/without chronic diseases. The Kaplan-Meier analysis revealed that our model could significantly categorize patients into high-risk and low-risk groups ( p < 0. 001). In conclusion, De-COVID19-Net can non-invasively predict whether a patient will die shortly based on the patient's initial CT scan with an impressive performance, which indicated that it could be used as a potential prognosis tool to alert high-risk patients and intervene in advance.

Details DOI

JBHI Journal 2020 Journal Article

Classification of Severe and Critical Covid-19 Using Deep Learning and Radiomics

  • Cong Li
  • Di Dong
  • Liang Li
  • Wei Gong
  • Xiaohu Li
  • Yan Bai
  • Meiyun Wang
  • Zhenhua Hu

Objective: The coronavirus disease 2019 (COVID-19) is rapidly spreading inside China and internationally. We aimed to construct a model integrating information from radiomics and deep learning (DL) features to discriminate critical cases from severe cases of COVID-19 using computed tomography (CT) images. Methods: We retrospectively enrolled 217 patients from three centers in China, including 82 patients with severe disease and 135 with critical disease. Patients were randomly divided into a training cohort (n = 174) and a test cohort (n = 43). We extracted 102 3-dimensional radiomic features from automatically segmented lung volume and selected the significant features. We also developed a 3-dimensional DL network based on center-cropped slices. Using multivariable logistic regression, we then created a merged model based on significant radiomic features and DL scores. We employed the area under the receiver operating characteristic curve (AUC) to evaluate the model's performance. We then conducted cross validation, stratified analysis, survival analysis, and decision curve analysis to evaluate the robustness of our method. Results: The merged model can distinguish critical patients with AUCs of 0. 909 (95% confidence interval [CI]: 0. 859–0. 952) and 0. 861 (95% CI: 0. 753–0. 968) in the training and test cohorts, respectively. Stratified analysis indicated that our model was not affected by sex, age, or chronic disease. Moreover, the results of the merged model showed a strong correlation with patient outcomes. Significance: A model combining radiomic and DL features of the lung could help distinguish critical cases from severe cases of COVID-19.

Details DOI

IJCAI Conference 2020 Conference Paper

Disentangled Feature Learning Network for Vehicle Re-Identification

  • Yan Bai
  • Yihang Lou
  • Yongxing Dai
  • Jun Liu
  • Ziqian Chen
  • Ling-Yu Duan

Vehicle Re-Identification (ReID) has attracted lots of research efforts due to its great significance to the public security. In vehicle ReID, we aim to learn features that are powerful in discriminating subtle differences between vehicles which are visually similar, and also robust against different orientations of the same vehicle. However, these two characteristics are hard to be encapsulated into a single feature representation simultaneously with unified supervision. Here we propose a Disentangled Feature Learning Network (DFLNet) to learn orientation specific and common features concurrently, which are discriminative at details and invariant to orientations, respectively. Moreover, to effectively use these two types of features for ReID, we further design a feature metric alignment scheme to ensure the consistency of the metric scales. The experiments show the effectiveness of our method that achieves state-of-the-art performance on three challenging datasets.

PDF Details DOI
v2026.09.13