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Xiuyuan Chen

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4 papers

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JBHI Journal 2026 Journal Article

Pathology-Guided AI System for Accurate Segmentation and Diagnosis of Cervical Spondylosis

Qi Zhang
Xiuyuan Chen
Ziyi He
Lianming Wu
Kun Wang
Jianqi Sun
Hongxing Shen

Cervical spondylosis, a complex and prevalent condition, demands precise and efficient diagnostic techniques for accurate assessment. While MRI offers detailed visualization of cervical spine anatomy, manual interpretation remains labor-intensive and prone to error. To address this, we developed an innovative AI-assisted Expert-based Diagnosis System 1 that automates both segmentation and diagnosis of cervical spondylosis using MRI. Leveraging multi-center datasets of cervical MRI images from patients with cervical spondylosis, our system features a pathology-guided segmentation model capable of accurately segmenting key cervical anatomical structures. The segmentation is followed by an expert-based diagnostic framework that automates the calculation of critical clinical indicators. Our segmentation model achieved an impressive average Dice coefficient exceeding 0. 90 across four cervical spinal anatomies and demonstrated enhanced accuracy in herniation areas. Diagnostic evaluation further showcased the system’s precision, with the lowest mean average errors (MAE) for the C2-C7 Cobb angle and the Maximum Spinal Cord Compression (MSCC) coefficient. In addition, our method delivered high accuracy, precision, recall, and F1 scores in herniation localization, K-line status assessment, T2 hyperintensity detection, and Kang grading. Comparative analysis and external validation demonstrate that our system outperforms existing methods, establishing a new benchmark for segmentation and diagnostic tasks for cervical spondylosis.

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JBHI Journal 2025 Journal Article

Accurate Cobb Angle Estimation via SVD-Based Curve Detection and Vertebral Wedging Quantification

Chang Shi
Nan Meng
Yipeng Zhuang
Jason Pui Yin Cheung
Moxin Zhao
Hua Huang
Xiuyuan Chen
Cong Nie

Adolescent idiopathic scoliosis (AIS) is a common spinal malalignment affecting approximately 2. 2% of boys and 4. 8% of girls worldwide. The Cobb angle serves as the gold standard for AIS severity assessment, yet traditional manual measurements suffer from significant observer variability, compromising diagnostic accuracy. Despite prior automation attempts, existing methods use simplified spinal models and predetermined curve patterns that fail to address clinical complexity. We present a novel deep learning framework for AIS assessment that simultaneously predicts both superior and inferior endplate angles with corresponding midpoint coordinates for each vertebra, preserving the anatomical reality of vertebral wedging in progressive AIS. Our approach combines an HRNet backbone with Swin-Transformer modules and biomechanically informed constraints for enhanced feature extraction. We employ Singular Value Decomposition (SVD) to analyze angle predictions directly from vertebral morphology, enabling flexible detection of diverse scoliosis patterns without predefined curve assumptions. Using 630 full-spine anteroposterior radiographs from patients aged 10-18 years with rigorous dual-rater annotation, our method achieved 83. 45% diagnostic accuracy and 2. 55 $^{\circ }$ mean absolute error. The framework demonstrates exceptional generalization capability on out-of-distribution cases. Additionally, we introduce the Vertebral Wedging Index (VWI), a novel metric quantifying vertebral deformation. Longitudinal analysis revealed VWI’s significant prognostic correlation with curve progression while traditional Cobb angles showed no correlation, providing robust support for early AIS detection, personalized treatment planning, and progression monitoring.

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NeurIPS Conference 2025 Conference Paper

PANTHER: Generative Pretraining Beyond Language for Sequential User Behavior Modeling

Guilin Li
Yun Zhang
Xiuyuan Chen
CHENGQI LI
Bo Wang
Linghe Kong
Wenjia Wang
Weiran Huang

Large language models (LLMs) have shown that generative pretraining can distill vast world knowledge into compact token representations. While LLMs encapsulate extensive world knowledge, they remain limited in modeling the behavioral knowledge contained within user interaction histories. User behavior forms a distinct modality, where each action—defined by multi-dimensional attributes such as time, context, and transaction type—constitutes a behavioral token. Modeling these high-cardinality, sparse, and irregular sequences is challenging, and discriminative models often falter under limited supervision. To bridge this gap, we extend generative pretraining to user behavior, learning transferable representations from unlabeled behavioral data analogous to how LLMs learn from text. We present PANTHER, a hybrid generative–discriminative framework that unifies user behavior pretraining and downstream adaptation, enabling large-scale sequential user representation learning and real-time inference. PANTHER introduces: (1) Structured Tokenization to compress multi-dimensional transaction attributes into an interpretable vocabulary; (2) Sequence Pattern Recognition Module (SPRM) for modeling periodic transaction motifs; (3) a Unified User-Profile Embedding that fuses static demographics with dynamic transaction histories, enabling both personalized predictions and population-level knowledge transfer; and (4) Real-time scalability enabled by offline caching of pre-trained embeddings for millisecond-level inference. Fully deployed and operational online at WeChat Pay, PANTHER delivers a 25. 6\% boost in next-transaction prediction HitRate@1 and a 38. 6\% relative improvement in fraud detection recall over baselines. Cross-domain evaluations on public benchmarks (CCT, MBD, MovieLens-1M, Yelp) show strong generalization, achieving up to 21\% HitRate@1 gains over transformer baselines, establishing PANTHER as a scalable, high-performance framework for industrial user sequential behavior modeling.

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EAAI Journal 2016 Journal Article

Optimal kernel choice for domain adaption learning

Le Dong
Ning Feng
Pinjie Quan
Gaipeng Kong
Xiuyuan Chen
Qianni Zhang

In this paper, a kernel choice method is proposed for domain adaption, referred to as Optimal Kernel Choice Domain Adaption (OKCDA). It learns a robust classier and parameters associated with Multiple Kernel Learning side by side. Domain adaption kernel-based learning strategy has shown outstanding performance. It embeds two domains of different distributions, namely, the auxiliary and the target domains, into Hilbert Space, and exploits the labeled data from the source domain to train a robust kernel-based SVM classier for the target domain. We reduce the distributions mismatch by setting up a test statistic between the two domains based on the Maximum Mean Discrepancy (MMD) algorithm and minimize the Type II error, given an upper bound on error I. Simultaneously, we minimize the structural risk functional. In order to highlight the advantages of the proposed method, we tackle a text classification problem on 20 Newsgroups dataset and Email Spam dataset. The results demonstrate that our method exhibits outstanding performance.

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