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Xing Fan

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8 papers

1 author row

YNICL Journal 2026 Journal Article

Functional gradient analysis reveals potential therapeutic mechanisms of nrTMS for postoperative motor deficits in glioma patients: A randomized controlled trial

Yuzhe Li
Jiangwei Wang
Zhong Zhang
Xing Fan
Yinyan Wang
Wenbin Ma
Tao Jiang
Shengyu Fang

OBJECTIVE: This study aimed to investigate the therapeutic effects and neural mechanisms of high-frequency neuro-navigated repetitive transcranial magnetic stimulation (nrTMS) targeting the hand knob in glioma patients with postoperative motor deficits, using functional gradient analysis to characterize cortical reorganization. METHODS: Thirty patients with postoperative motor deficits were randomized to receive nrTMS or sham stimulation targeting the ipsilateral hand knob. Motor function was assessed using Fugl-Meyer Assessment (FMA) and muscle strength. Resting-state fMRI was acquired to compute principal functional gradients. Control/tumor, nrTMS/sham, and Pre-TMS/Post-TMS gradient changes were analyzed. Correlation and regression analyses related to motor recovery were performed. RESULTS: The nrTMS group showed significantly greater improvement in muscle strength (Post-treatment: nrTMS: 3.533 ± 0.720, Sham: 2.067 ± 0.572, p = 0.019, d = 1.082; 3-month follow-up: nrTMS: 4.600 ± 0.408, Sham: 3.733 ± 0.609, p = 0.035, d = 1.012). Gradient analysis revealed increased sensorimotor network (SMN) gradient scores following nrTMS (Pre-TMS: -0.707 ± 0.108; Post-TMS: -0.636 ± 0.077; p = 0.016), and HH_SomMot_22 within upper limb motor cortex is most strongly correlated with motor recovery. CONCLUSIONS: High-frequency nrTMS targeting the hand knob accelerated the motor recovery. Gradient analysis findings provide novel insights into therapeutic mechanisms of nrTMS and underscore the value of the hand knob as a stimulation target.

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YNIMG Journal 2025 Journal Article

Driving brain state transitions via Adaptive Local Energy Control Model

Rong Yao
Langhua Shi
Yan Niu
Haifang Li
Xing Fan
Bin Wang

The brain, as a complex system, achieves state transitions through interactions among its regions and also performs various functions. An in-depth exploration of brain state transitions is crucial for revealing functional changes in both health and pathological states and realizing precise brain function intervention. Network control theory offers a novel framework for investigating the dynamic characteristics of brain state transitions. Existing studies have primarily focused on analyzing the energy required for brain state transitions, which are driven either by the single brain region or by all brain regions. However, they often neglect the critical question of how the whole brain responds to external control inputs that are driven by control energy from multiple brain regions, which limits their application value in guiding clinical neurostimulation. In this paper, we proposed the Adaptive Local Energy Control Model (ALECM) to explore brain state transitions, which considers the complex interactions of the whole brain along the white matter network when external control inputs are applied to multiple regions. It not only quantifies the energy required for state transitions but also predicts their outcomes based on local control. Our results indicated that patients with Schizophrenia (SZ) and Bipolar Disorder (BD) required more energy to drive the brain state transitions from the pathological state to the healthy baseline state, which is defined as Hetero-state transition. Importantly, we successfully induced Hetero-state transition in the patients' brains by using the ALECM, with subnetworks or specific brain regions serving as local control sets. Eventually, the network similarity between patients and healthy subjects reached baseline levels. These offer evidence that the ALECM can effectively quantify the cost characteristics of brain state transitions, providing a theoretical foundation for accurately predicting the efficacy of electromagnetic perturbation therapies in the future.

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IS Journal 2024 Journal Article

Foundation Models for Education: Promises and Prospects

Tianlong Xu
Richard Tong
Jing Liang
Xing Fan
Haoyang Li
Qingsong Wen

With the advent of foundation models like ChatGPT, educators are excited about the transformative role that artificial intelligence (AI) might play in propelling the next education revolution. The developing speed and the profound impact of foundation models in various industries force us to think deeply about the changes they will make to education, a domain that is critically important for the future of humans. In this article, we discuss the strengths of foundation models, such as personalized learning, education inequality, and reasoning capabilities, as well as the development of agent architecture tailored for education, which integrates AI agents with pedagogical frameworks to create adaptive learning environments. Furthermore, we highlight the risks and opportunities of AI overreliance and creativity. Finally, we envision a future where foundation models in education harmonize human and AI capabilities, fostering a dynamic, inclusive, and adaptive educational ecosystem.

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JMLR Journal 2022 Journal Article

ALMA: Alternating Minimization Algorithm for Clustering Mixture Multilayer Network

Xing Fan
Marianna Pensky
Feng Yu
Teng Zhang

The paper considers a Mixture Multilayer Stochastic Block Model (MMLSBM), where layers can be partitioned into groups of similar networks, and networks in each group are equipped with a distinct Stochastic Block Model. The goal is to partition the multilayer network into clusters of similar layers, and to identify communities in those layers. Jing et al. (2020) introduced the MMLSBM and developed a clustering methodology, TWIST, based on regularized tensor decomposition. The present paper proposes a different technique, an alternating minimization algorithm (ALMA), that aims at simultaneous recovery of the layer partition, together with estimation of the matrices of connection probabilities of the distinct layers. Compared to TWIST, ALMA achieves higher accuracy, both theoretically and numerically. [abs] [ pdf ][ bib ] &copy JMLR 2022. ( edit, beta )

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AAAI Conference 2020 Conference Paper

Knowledge Distillation from Internal Representations

Gustavo Aguilar
Yuan Ling
Yu Zhang
Benjamin Yao
Xing Fan
Chenlei Guo

Knowledge distillation is typically conducted by training a small model (the student) to mimic a large and cumbersome model (the teacher). The idea is to compress the knowledge from the teacher by using its output probabilities as softlabels to optimize the student. However, when the teacher is considerably large, there is no guarantee that the internal knowledge of the teacher will be transferred into the student; even if the student closely matches the soft-labels, its internal representations may be considerably different. This internal mismatch can undermine the generalization capabilities originally intended to be transferred from the teacher to the student. In this paper, we propose to distill the internal representations of a large model such as BERT into a simpliﬁed version of it. We formulate two ways to distill such representations and various algorithms to conduct the distillation. We experiment with datasets from the GLUE benchmark and consistently show that adding knowledge distillation from internal representations is a more powerful method than only using soft-label distillation.

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YNICL Journal 2019 Journal Article

A quantitative SVM approach potentially improves the accuracy of magnetic resonance spectroscopy in the preoperative evaluation of the grades of diffuse gliomas

Chong Qi
Yiming Li
Xing Fan
Yin Jiang
Rui Wang
Song Yang
Lanxi Meng
Tao Jiang

OBJECTIVES: H-MRS) metabolic features and the grade of gliomas, and to establish a machine-learning model to predict the glioma grade. METHODS: H-MRS image. The Student's t-test was conducted to screen for differentially expressed features between low- and high-grade gliomas (WHO grades II and III/IV, respectively). Next, the minimum Redundancy Maximum Relevance (mRMR) algorithm was performed to further select features for a support vector machine (SVM) classifier building. Performance of the predictive model was evaluated both in the training and validation sets using ROC curve analysis. RESULTS: H-MRS metabolic features, thirteen features were differentially expressed. Four features were further selected as grade-predictive imaging signatures using the mRMR algorithm. The predictive performance of the machine-learning model measured by the AUC was 0.825 and 0.820 in the training and validation sets, respectively. This was better than the predictive performances of individual metabolic features, the best of which was 0.812. CONCLUSIONS: H-MRS metabolic features could help in predicting the grade of gliomas. The machine-learning model achieved a better prediction performance in grading gliomas than individual features, indicating that it could complement the traditionally used metabolic features.

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YNICL Journal 2018 Journal Article

A radiomic signature as a non-invasive predictor of progression-free survival in patients with lower-grade gliomas

Xing Liu
Yiming Li
Zenghui Qian
Zhiyan Sun
Kaibin Xu
Kai Wang
Shuai Liu
Xing Fan

OBJECTIVE: The aim of this study was to develop a radiomics signature for prediction of progression-free survival (PFS) in lower-grade gliomas and to investigate the genetic background behind the radiomics signature. METHODS: In this retrospective study, training (n = 216) and validation (n = 84) cohorts were collected from the Chinese Glioma Genome Atlas and the Cancer Genome Atlas, respectively. For each patient, a total of 431 radiomics features were extracted from preoperative T2-weighted magnetic resonance images. A radiomics signature was generated in the training cohort, and its prognostic value was evaluated in both the training and validation cohorts. The genetic characteristics of the group with high-risk scores were identified by radiogenomic analysis, and a nomogram was established for prediction of PFS. RESULTS: There was a significant association between the radiomics signature (including 9 screened radiomics features) and PFS, which was independent of other clinicopathologic factors in both the training (P < 0.001, multivariable Cox regression) and validation (P = 0.045, multivariable Cox regression) cohorts. Radiogenomic analysis revealed that the radiomics signature was associated with the immune response, programmed cell death, cell proliferation, and vasculature development. A nomogram established using the radiomics signature and clinicopathologic risk factors demonstrated high accuracy and good calibration for prediction of PFS in both the training (C-index, 0.684) and validation (C-index, 0.823) cohorts. CONCLUSIONS: PFS can be predicted non-invasively in patients with LGGs by a group of radiomics features that could reflect the biological processes of these tumors.

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YNICL Journal 2018 Journal Article

MRI features predict p53 status in lower-grade gliomas via a machine-learning approach

Yiming Li
Zenghui Qian
Kaibin Xu
Kai Wang
Xing Fan
Shaowu Li
Tao Jiang
Xing Liu

Background: P53 mutation status is a pivotal biomarker for gliomas. Here, we developed a machine-learning model to predict p53 status in lower-grade gliomas based on radiomic features extracted from conventional magnetic resonance (MR) images. Methods: = 92) set. A total of 431 radiomic features were extracted from each patient. The lest absolute shrinkage and selection operator (LASSO) method was used for feature selection and radiomic signature construction. Subsequently, a machine-learning model to predict p53 status was established using the selected features and a Support Vector Machine classifier. The predictive performance of all individual features and the model was calculated using receiver operating characteristic curves in both the training and validation sets. Results: The p53-related radiomic signature was built using the LASSO algorithm; this procedure consisted of four first-order statistics or related wavelet features (including Maximum, Median, Minimum, and Uniformity), a shape and size-based feature (Spherical Disproportion), and ten textural features or related wavelet features (including Correlation, Run Percentage, and Sum Entropy). The prediction accuracies based on the area under the curve were 89.6% in the training set and 76.3% in the validation set, which were better than individual features. Conclusions: These results demonstrate that MR image texture features are predictive of p53 mutation status in lower-grade gliomas. Thus, our procedure can be conveniently used to facilitate presurgical molecular pathological diagnosis.

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