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Xiaotong Li

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10 papers

2 author rows

AAAI Conference 2026 Conference Paper

Hierarchical Direction Perception via Atomic Dot-Product Operators for Rotation-Invariant Point Clouds Learning

Chenyu Hu
Xiaotong Li
Hao Zhu
Biao Hou

Point cloud processing has become a cornerstone technology in many 3D vision tasks. However, arbitrary rotations introduce variations in point cloud orientations, posing a long-standing challenge for effective representation learning. The core of this issue is the disruption of the point cloud's intrinsic directional characteristics caused by rotational perturbations. Recent methods attempt to implicitly model rotational equivariance and invariance, preserving directional information and propagating it into deep semantic spaces. Yet, they often fall short of fully exploiting the multiscale directional nature of point clouds to enhance feature representations. To address this, we propose the Direction-Perceptive Vector Network (DiPVNet). At its core is an atomic dot-product operator that simultaneously encodes directional selectivity and rotation invariance--endowing the network with both rotational symmetry modeling and adaptive directional perception. At the local level, we introduce a Learnable Local Dot-Product (L2DP) Operator, which enables interactions between a center point and its neighbors to adaptively capture the non-uniform local structures of point clouds. At the global level, we leverage generalized harmonic analysis to prove that the dot-product between point clouds and spherical sampling vectors is equivalent to a direction-aware spherical Fourier transform (DASFT). This leads to the construction of a global directional response spectrum for modeling holistic directional structures. We rigorously prove the rotation invariance of both operators. Extensive experiments on challenging scenarios involving noise and large-angle rotations demonstrate that DiPVNet achieves state-of-the-art performance on point cloud classification and segmentation tasks.

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ICML Conference 2025 Conference Paper

Beyond Entropy: Region Confidence Proxy for Wild Test-Time Adaptation

Zixuan Hu
Yichun Hu
Xiaotong Li
Shixiang Tang
Lingyu Duan

Wild Test-Time Adaptation (WTTA) is proposed to adapt a source model to unseen domains under extreme data scarcity and multiple shifts. Previous approaches mainly focused on sample selection strategies, while overlooking the fundamental problem on underlying optimization. Initially, we critically analyze the widely-adopted entropy minimization framework in WTTA and uncover its significant limitations in noisy optimization dynamics that substantially hinder adaptation efficiency. Through our analysis, we identify region confidence as a superior alternative to traditional entropy, however, its direct optimization remains computationally prohibitive for real-time applications. In this paper, we introduce a novel region-integrated method ReCAP that bypasses the lengthy process. Specifically, we propose a probabilistic region modeling scheme that flexibly captures semantic changes in embedding space. Subsequently, we develop a finite-to-infinite asymptotic approximation that transforms the intractable region confidence into a tractable and upper-bounded proxy. These innovations significantly unlock the overlooked potential dynamics in local region in a concise solution. Our extensive experiments demonstrate the consistent superiority of ReCAP over existing methods across various datasets and wild scenarios. The source code will be available at https: //github. com/hzcar/ReCAP.

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NeurIPS Conference 2024 Conference Paper

DenseFusion-1M: Merging Vision Experts for Comprehensive Multimodal Perception

Xiaotong Li
Fan Zhang
Haiwen Diao
Yueze Wang
Xinlong Wang
Ling-Yu Duan

Existing Multimodal Large Language Models (MLLMs) increasingly emphasize complex understanding of various visual elements, including multiple objects, text information, spatial relations. Their development for comprehensive visual perception hinges on the availability of high-quality image-text datasets that offer diverse visual elements and throughout image descriptions. However, the scarcity of such hyper-detailed datasets currently hinders progress within the MLLM community. The bottleneck stems from the limited perceptual capabilities of current caption engines, which fall short in providing complete and accurate annotations. To facilitate the cutting-edge research of MLLMs on comprehensive vision perception, we thereby propose Perceptual Fusion, using a low-budget but highly effective caption engine for complete and accurate image descriptions. Specifically, Perceptual Fusion integrates diverse perception experts as image priors to provide explicit information on visual elements and adopts an efficient MLLM as a centric pivot to mimic advanced MLLMs' perception abilities. We carefully select 1M highly representative images from uncurated LAION dataset and generate dense descriptions using our engine, dubbed DenseFusion-1M. Extensive experiments validate that our engine outperforms its counterparts, where the resulting dataset significantly improves the perception and cognition abilities of existing MLLMs across diverse vision-language benchmarks, especially with high-resolution images as inputs. The code and dataset are available at https: //huggingface. co/datasets/BAAI/DenseFusion-1M.

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NeurIPS Conference 2024 Conference Paper

DePLM: Denoising Protein Language Models for Property Optimization

Zeyuan Wang
Keyan Ding
Ming Qin
Xiaotong Li
Xiang Zhuang
Yu Zhao
Jianhua Yao
Qiang Zhang

Protein optimization is a fundamental biological task aimed at enhancing theperformance of proteins by modifying their sequences. Computational methodsprimarily rely on evolutionary information (EI) encoded by protein languagemodels (PLMs) to predict fitness landscape for optimization. However, thesemethods suffer from a few limitations. (1) Evolutionary processes involve thesimultaneous consideration of multiple functional properties, often overshadowingthe specific property of interest. (2) Measurements of these properties tend to betailored to experimental conditions, leading to reduced generalizability of trainedmodels to novel proteins. To address these limitations, we introduce DenoisingProtein Language Models (DePLM), a novel approach that refines the evolutionaryinformation embodied in PLMs for improved protein optimization. Specifically, weconceptualize EI as comprising both property-relevant and irrelevant information, with the latter acting as “noise” for the optimization task at hand. Our approachinvolves denoising this EI in PLMs through a diffusion process conducted in therank space of property values, thereby enhancing model generalization and ensuringdataset-agnostic learning. Extensive experimental results have demonstrated thatDePLM not only surpasses the state-of-the-art in mutation effect prediction butalso exhibits strong generalization capabilities for novel proteins.

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ICML Conference 2024 Conference Paper

Knowledge-aware Reinforced Language Models for Protein Directed Evolution

Yuhao Wang
Qiang Zhang 0026
Ming Qin
Xiang Zhuang
Xiaotong Li
Zhichen Gong
Zeyuan Wang
Yu Zhao 0009

Directed evolution, a cornerstone of protein optimization, is to harness natural mutational processes to enhance protein functionality. Existing Machine Learning-assisted Directed Evolution (MLDE) methodologies typically rely on data-driven strategies and often overlook the profound domain knowledge in biochemical fields. In this paper, we introduce a novel Knowledge-aware Reinforced Language Model (KnowRLM) for MLDE. An Amino Acid Knowledge Graph (AAKG) is constructed to represent the intricate biochemical relationships among amino acids. We further propose a Protein Language Model (PLM)-based policy network that iteratively samples mutants through preferential random walks on the AAKG using a dynamic sliding window mechanism. The novel mutants are actively sampled to fine-tune a fitness predictor as the reward model, providing feedback to the knowledge-aware policy. Finally, we optimize the whole system in an active learning approach that mimics biological settings in practice. KnowRLM stands out for its ability to utilize contextual amino acid information from knowledge graphs, thus attaining advantages from both statistical patterns of protein sequences and biochemical properties of amino acids. Extensive experiments demonstrate the superior performance of KnowRLM in more efficiently identifying high-fitness mutants compared to existing methods.

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NeurIPS Conference 2024 Conference Paper

Unveiling Encoder-Free Vision-Language Models

Haiwen Diao
Yufeng Cui
Xiaotong Li
Yueze Wang
Huchuan Lu
Xinlong Wang

Existing vision-language models (VLMs) mostly rely on vision encoders to extract visual features followed by large language models (LLMs) for visual-language tasks. However, the vision encoders set a strong inductive bias in abstracting visual representation, e. g. , resolution, aspect ratio, and semantic priors, which could impede the flexibility and efficiency of the VLMs. Training pure VLMs that accept the seamless vision and language inputs, i. e. , without vision encoders, remains challenging and rarely explored. Empirical observations reveal that direct training without encoders results in slow convergence and large performance gaps. In this work, we bridge the gap between encoder-based and encoder-free models, and present a simple yet effective training recipe towards pure VLMs. Specifically, we unveil the key aspects of training encoder-free VLMs efficiently via thorough experiments: (1) Bridging vision-language representation inside one unified decoder; (2) Enhancing visual recognition capability via extra supervision. With these strategies, we launch EVE, an encoder-free vision-language model that can be trained and forwarded efficiently. Notably, solely utilizing 35M publicly accessible data, EVE can impressively rival the encoder-based VLMs of similar capacities across multiple vision-language benchmarks. It significantly outperforms the counterpart Fuyu-8B with mysterious training procedures and undisclosed training data. We believe that EVE provides a transparent and efficient route for developing pure decoder-only architecture across modalities.

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ICLR Conference 2023 Conference Paper

Cycle-consistent Masked AutoEncoder for Unsupervised Domain Generalization

Haiyang Yang
Xiaotong Li
Shixiang Tang
Feng Zhu 0006
Yizhou Wang 0007
Meilin Chen
Lei Bai 0001
Rui Zhao 0001

Self-supervised learning methods undergo undesirable performance drops when there exists a significant domain gap between training and testing scenarios. Therefore, unsupervised domain generalization (UDG) is proposed to tackle the problem, which requires the model to be trained on several different domains without supervision and generalize well on unseen test domains. Existing methods either rely on a cross-domain and semantically consistent image pair in contrastive methods or the reconstruction pair in generative methods, while the precious image pairs are not available without semantic labels. In this paper, we propose a cycle cross-domain reconstruction task for unsupervised domain generalization in the absence of paired images. The cycle cross-domain reconstruction task converts a masked image from one domain to another domain and then reconstructs the original image from the converted images. To preserve the divergent domain knowledge of decoders in the cycle reconstruction task, we propose a novel domain-contrastive loss to regularize the domain information in reconstructed images encoded with the desirable domain style. Qualitative results on extensive datasets illustrate our method improves the state-of-the-art unsupervised domain generalization methods by average $\textbf{+5.59\%}, \textbf{+4.52\%}, \textbf{+4.22\%}, \textbf{+7.02\%}$ on $1\%, 5\%, 10\%, 100\%$ PACS, and $\textbf{+5.08\%}, \textbf{+6.49\%}, \textbf{+1.79\%}, \textbf{+0.53\%}$ on $1\%, 5\%, 10\%, 100\%$ DomainNet, respectively.

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ICLR Conference 2023 Conference Paper

Masked Image Modeling with Denoising Contrast

Kun Yi
Yixiao Ge
Xiaotong Li
Shusheng Yang
Dian Li
Jianping Wu
Ying Shan
Xiaohu Qie

Since the development of self-supervised visual representation learning from contrastive learning to masked image modeling (MIM), there is no significant difference in essence, that is, how to design proper pretext tasks for vision dictionary look-up. MIM recently dominates this line of research with state-of-the-art performance on vision Transformers (ViTs), where the core is to enhance the patch-level visual context capturing of the network via denoising auto-encoding mechanism. Rather than tailoring image tokenizers with extra training stages as in previous works, we unleash the great potential of contrastive learning on de- noising auto-encoding and introduce a pure MIM method, ConMIM, to produce simple intra-image inter-patch contrastive constraints as the sole learning objectives for masked patch prediction. We further strengthen the denoising mechanism with asymmetric designs, including image perturbations and model progress rates, to improve the network pre-training. ConMIM-pretrained models with various scales achieve competitive results on downstream image classification, semantic segmentation, object detection, and instance segmentation tasks, e.g., on ImageNet-1K classification, we achieve 83.9% top-1 accuracy with ViT-Small and 85.3% with ViT-Base without extra data for pre-training. Code will be available at https://github.com/TencentARC/ConMIM.

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IJCAI Conference 2022 Conference Paper

TCCNet: Temporally Consistent Context-Free Network for Semi-supervised Video Polyp Segmentation

Xiaotong Li
Jilan Xu
Yuejie Zhang
Rui Feng
Rui-Wei Zhao
Tao Zhang
Xuequan Lu
Shang Gao

Automatic video polyp segmentation (VPS) is highly valued for the early diagnosis of colorectal cancer. However, existing methods are limited in three respects: 1) most of them work on static images, while ignoring the temporal information in consecutive video frames; 2) all of them are fully supervised and easily overfit in presence of limited annotations; 3) the context of polyp (i. e. , lumen, specularity and mucosa tissue) varies in an endoscopic clip, which may affect the predictions of adjacent frames. To resolve these challenges, we propose a novel Temporally Consistent Context-Free Network (TCCNet) for semi-supervised VPS. It contains a segmentation branch and a propagation branch with a co-training scheme to supervise the predictions of unlabeled image. To maintain the temporal consistency of predictions, we design a Sequence-Corrected Reverse Attention module and a Propagation-Corrected Reverse Attention module. A Context-Free Loss is also proposed to mitigate the impact of varying contexts. Extensive experiments show that even trained under 1/15 label ratio, TCCNet is comparable to the state-of-the-art fully supervised methods for VPS. Also, TCCNet surpasses existing semi-supervised methods for natural image and other medical image segmentation tasks.

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ICLR Conference 2022 Conference Paper

Uncertainty Modeling for Out-of-Distribution Generalization

Xiaotong Li
Yongxing Dai
Yixiao Ge
Jun Liu 0036
Ying Shan
Lingyu Duan

Though remarkable progress has been achieved in various vision tasks, deep neural networks still suffer obvious performance degradation when tested in out-of-distribution scenarios. We argue that the feature statistics (mean and standard deviation), which carry the domain characteristics of the training data, can be properly manipulated to improve the generalization ability of deep learning models. Common methods often consider the feature statistics as deterministic values measured from the learned features and do not explicitly consider the uncertain statistics discrepancy caused by potential domain shifts during testing. In this paper, we improve the network generalization ability by modeling the uncertainty of domain shifts with synthesized feature statistics during training. Specifically, we hypothesize that the feature statistic, after considering the potential uncertainties, follows a multivariate Gaussian distribution. Hence, each feature statistic is no longer a deterministic value, but a probabilistic point with diverse distribution possibilities. With the uncertain feature statistics, the models can be trained to alleviate the domain perturbations and achieve better robustness against potential domain shifts. Our method can be readily integrated into networks without additional parameters. Extensive experiments demonstrate that our proposed method consistently improves the network generalization ability on multiple vision tasks, including image classification, semantic segmentation, and instance retrieval.

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