Author name cluster

Xiaohua Wan

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

4 papers

1 author row

JBHI Journal 2026 Journal Article

A VR-based Automated Strabismus Diagnosis System with Progressive Semi-Supervised Learning

Dehui Qiu
Bowei Ma
Ze Xiong
Yuhao Wang
Liguo Deng
Longfei Zhou
Xiaojie Cao
Weiwei Chen

Strabismus is a prevalent ocular disorder that can impair visual development and cause psychological issues if not diagnosed early. Conventional clinical diagnosis primarily relies on the prism cover test (PCT), which is subjective, requires patient cooperation, and lacks standardization. Recent advances in virtual reality (VR) and deep learning offer promising solutions for automated and standardized diagnosis. However, practical deployment faces three key challenges: realistic VR simulation of clinical exams, addressing image degradation (reflections/occlusions) with limited annotated data, and precise quantification of ocular deviations. In this study, we propose a novel VR-based automated strabismus diagnosis system by leveraging semi-supervised deep learning, and introduce a new clinical dataset, TongRenD. The framework incorporates five standardized clinical examination scenarios within a VR environment to ensure diagnostic consistency. We introduce ProgNet: an uncertainty-guided progressive semi-supervised segmentation network that integrates a Prototype-based Feature Representation Module (PFRM) to enhance robustness against visual noise and distortions under limited annotations. A dedicated 3D deviation estimation algorithm further enables accurate strabismus classification and angular measurement. Extensive experiments on the TongRenD and TEyeD datasets demonstrate that ProgNet outperforms state-of-the-art methods in segmentation accuracy. Clinical validation confirms that our system achieves high consistency with expert assessments, providing a standardized, non-invasive, and reliable solution for strabismus diagnosis.

Details DOI

JBHI Journal 2026 Journal Article

CFCDBN: Personalized Directional Brain Network Modeling of Cross-Frequency Coupling Alterations in Adolescent Anxiety Disorders

Dixin Wang
Na Chu
Shuting Sun
Cancheng Li
Gang Luo
Shanshan Qu
Lixian Zhu
Xiaohua Wan

Anxiety disorders (AD) are prevalent psychiatric conditions that profoundly impact adolescent neural development. Abnormal delta–beta cross-frequency coupling (CFC) has been identified as a key electrophysiological marker of altered neural dynamics in individuals with AD. However, most existing studies focus on static analysis within restricted brain regions and predefined frequency bands, which limits the understanding of large-scale dynamic neural communication. Therefore, we propose a novel cross-frequency coupling directed brain network (CFCDBN) framework, which integrates personalized CFC estimation and causal information flow modeling to capture the dynamic interactions of the brain network in AD. Personalized CFC significantly improves the precise representation of AD-related neural dynamics by adaptive frequency band division and individualized oscillation feature extraction, overcoming the limitations of traditional CFC methods. The analysis reveals significant delta-beta coupling abnormalities in the left hemisphere of AD, accompanied by disrupted directional pathways involving the thalamus, precuneus, and insula. These findings suggest impaired emotional and cognitive communication from the subcortical to cortical regions. To validate the efficacy of CFCDBN in distinguishing AD patients from healthy individuals, we developed a direction-aware graph neural network (DA-GNN) model that uses CFCDBN representations as input to capture dynamic neural patterns in causal brain connectivity. Experimental results show that the model consistently outperforms traditional machine learning methods and undirected GNN baselines in automatic AD identification, achieving a classification accuracy of 77. 8%, and confirming the value of CFCDBN as a robust biomarker for AD-related network dysfunction. These findings not only deepen our understanding of the neural dynamics underlying AD, but also lay the foundation for personalized and mechanism-driven neuromodulation strategies. The core implementation of the CFCDBN framework is available on GitHub: https://github.com/wdxcjnb6/CFCDBN.

Details DOI

AAAI Conference 2026 Conference Paper

Cyto-SSL: A Self-Supervised Pretraining Framework for Cytology Foundation Model

Yiming Zhang
Rui Yan
Xiaohua Wan
Yifan Zhao
Shuang Feng
Zhetao Xu
Ying Wang
Fa Zhang

Cytological images originate from exfoliated cells, collected via liquid-based slides and digitized into whole slide images (WSIs). Unlike histological WSIs that exhibit continuous and well-structured tissue, cytological WSIs are sparse in spatial distribution and unstructured in cellular relationships. Typically, the nucleus serves as the primary diagnostic feature, while surrounding cytoplasmic information plays a supportive role. These unique characteristics limit the development of effective foundation models and hinder the transferability of histology-based models for cytopathology. To address this, we propose **Cyto-SSL**, the first self-supervised pretraining framework for cytological images. It introduces **Nuclei-Centered Perturbation**, which highlights individual nuclei by perturbing non-nuclear regions. We also design an SR-Transformer module, which complements this by using sparse attention to concentrate on diagnostically relevant scattered cells, while iRPE helps model to capture local spatial relationships and avoids unnecessary attention to irrelevant global structures. Experimental results show that **Cyto-SSL** enhances performance across diverse cytological datasets and Multiple Instance Learning (MIL) methods. On a WSI-level dataset, it achieved 95.67% accuracy and outperformed ImageNet-pretrained ResNet-50 by 11.33%, demonstrating superior feature representation for cytological analysis. Additionally, **Cyto-SSL** modules are plug-and-play, easily integrated into other pretraining frameworks, yielding a 2.6% accuracy gain across different SSL methods.

PDF Details DOI

AAAI Conference 2026 Conference Paper

ST-LLM: Spatial Transcriptomics Embedding with Large Language Models

Zhetao Xu
Xiaohua Wan
Le Li
Shuang Feng
Yiming Zhang
Fa Zhang
Bin Hu

Spatial transcriptomics provides unprecedented opportunities to analyze gene patterns while preserving spatial tissue architecture. However, traditional deep learning methods for spatial transcriptomics analysis face significant challenges in multi-modal data integration, spatial dependency modeling, and biological knowledge incorporation, while existing large language models lack explicit spatial modeling capabilities for transcriptomic data. So we first present a Spatial Transcriptomics Embedding with Large Language Models (ST-LLM), a novel simple and effective approach that transforms intricate spatial graph structures into structured textual representations suitable for large language models (LLMs). ST-LLM dynamically constructs graph adjacency construction using reinforcement learning paradigms to adaptively optimize spatial relationships, converts the resulting graphs into hierarchical textual descriptions with spatial context, and leverages pre-trained semantic understanding to generate high-dimensional spatial-aware representations. Comprehensive experiments on 14 datasets demonstrate that ST-LLM achieves comparable or better performance than traditional model. ST-LLM shows that LLMs embeddings provide a new simple and effective path to encoding spatial transcriptomics biological knowledge.

PDF Details DOI