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Xiaohua Chen

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3 papers
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3

AAAI Conference 2022 Conference Paper

Imagine by Reasoning: A Reasoning-Based Implicit Semantic Data Augmentation for Long-Tailed Classification

  • Xiaohua Chen
  • Yucan Zhou
  • Dayan Wu
  • Wanqian Zhang
  • Yu Zhou
  • Bo Li
  • Weiping Wang

Real-world data often follows a long-tailed distribution, which makes the performance of existing classification algorithms degrade heavily. A key issue is that samples in tail categories fail to depict their intra-class diversity. Humans can imagine a sample in new poses, scenes, and view angles with their prior knowledge even if it is the first time to see this category. Inspired by this, we propose a novel reasoning-based implicit semantic data augmentation method to borrow transformation directions from other classes. Since the covariance matrix of each category represents the feature transformation directions, we can sample new directions from similar categories to generate definitely different instances. Specifically, the long-tailed distributed data is first adopted to train a backbone and a classifier. Then, a covariance matrix for each category is estimated, and a knowledge graph is constructed to store the relations of any two categories. Finally, tail samples are adaptively enhanced via propagating information from all the similar categories in the knowledge graph. Experimental results on CIFAR-100-LT, ImageNet-LT, and iNaturalist 2018 have demonstrated the effectiveness of our proposed method compared with the state-of-the-art methods.

YNIMG Journal 2007 Journal Article

Sex differences in regional gray matter in healthy individuals aged 44–48 years: A voxel-based morphometric study

  • Xiaohua Chen
  • Perminder S. Sachdev
  • Wei Wen
  • Kaarin J. Anstey

The study examined sex-related differences in regional gray matter (GM) in 44–48 year old healthy individuals. T1-weighted MRI scans were acquired in 411 subjects aged 44–48 from a random community sample and optimized voxel-based morphometry was applied to detect regional GM difference between men and women, correcting for effects of age, years of education, handedness, and total intracranial volume (TIV). Men had larger brain volumes and higher white matter (WM) to TIV ratios compared with women. Women had higher GM to TIV ratios than men. After controlling for age, years of education, handedness, and TIV, there were no significant differences between men and women in the total GM volumes. Regional sex dimorphism was present, with men having more GM volume in midbrain, left inferior temporal gyrus, right occipital lingual gyrus, right middle temporal gyrus, and both cerebellar hemispheres. Women showed more GM in dorsal anterior, posterior and ventral cingulate cortices, and right inferior parietal lobule. Our results suggest sex dimorphism in GM in middle aged healthy individuals, which is not likely to be explained by brain pathology. These differences may provide the structural brain basis for sex differences in certain cognitive functions.

YNIMG Journal 2006 Journal Article

Gray matter reduction is correlated with white matter hyperintensity volume: A voxel-based morphometric study in a large epidemiological sample

  • Wei Wen
  • Perminder S. Sachdev
  • Xiaohua Chen
  • Kaarin Anstey

Both brain atrophy and T2-weighted white matter hyperintensities (WMH) are common findings in the brains of asymptomatic elderly individuals as well as in disease-specific brains. The study of the relationship between these two salient features is therefore important. To investigate such a relationship, we performed a brain magnetic resonance imaging (MRI) study on 397 asymptomatic individuals aged between 60 and 64 years, who were recruited randomly from a large community sample. WMH were delineated on T2-weighted fluid attenuation inversion recovery (FLAIR) whole brain scans using an automated procedure. The results showed that gray matter reduction, subarachnoid CSF (SA-CSF) increase and lateral ventricular dilation were significantly correlated with WMH load. Deep white matter hyperintensity (DWMH) had significant correlation with all three global atrophy indices, but periventricular white matter hyperintensity (PVWMH) was correlated only with gray matter volume. Voxel-based morphometric (VBM) analysis showed that regional gray matter reduction correlated more closely with WMH load of the proximate region than with WMH elsewhere. The results suggest that WMH have a relationship with brain atrophy in middle age, although the study cannot determine which process, i. e. the development of WMH or atrophy, is primary. The study also demonstrates that DWMH has a more significant relationship with structural brain changes, and may therefore be more functionally relevant than PVWMH. Further delineation of this relationship needs a longitudinal study of the changes in both WMH and indices of brain atrophy.

v2026.09.13