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Wenjun Li

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25 papers
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AAAI Conference 2025 Conference Paper

Marginal Benefit Driven RL Teacher for Unsupervised Environment Design

  • Dexun Li
  • Wenjun Li
  • Pradeep Varakantham

Training generally capable agents in complex environments is a challenging task that involves identifying "right" environments at the training stage. Recent research has highlighted the potential of the Unsupervised Environment Design framework, which generates environment instances/levels adaptively at the frontier of the agent’s capabilities using regret measures. While regret approaches have shown great promise in generating feasible environments, they can produce difficult environments that are challenging for an RL agent to learn from. This is because regret represents the best-case (upper bound) learning potential and not the actual learning potential of an environment. To address this limitation, we propose an alternative mechanism that employs marginal benefit, focusing on the improvement (in terms of generalized performance) the agent policy gets for a given environment. The advantage of this new mechanism is that it is agent-focused (and not environment focused) and generates the "right" environments depending on the agent's policy. Additionally, to improve the generalizability of the agent, we introduce representative state diversity metric that aims to generate varied experiences for the agent. Finally, we provide detailed experimental results and ablation analysis to showcase the effectiveness of our new methods. We obtain SOTA results among RL based environment generation methods.

NeurIPS Conference 2024 Conference Paper

Improving Environment Novelty Quantification for Effective Unsupervised Environment Design

  • Jayden Teoh
  • Wenjun Li
  • Pradeep Varakantham

Unsupervised Environment Design (UED) formalizes the problem of autocurricula through interactive training between a teacher agent and a student agent. The teacher generates new training environments with high learning potential, curating an adaptive curriculum that strengthens the student's ability to handle unseen scenarios. Existing UED methods mainly rely on regret, a metric that measures the difference between the agent's optimal and actual performance, to guide curriculum design. Regret-driven methods generate curricula that progressively increase environment complexity for the student but overlook environment novelty — a critical element for enhancing an agent's generalizability. Measuring environment novelty is especially challenging due to the underspecified nature of environment parameters in UED, and existing approaches face significant limitations. To address this, this paper introduces the Coverage-based Evaluation of Novelty In Environment (CENIE) framework. CENIE proposes a scalable, domain-agnostic, and curriculum-aware approach to quantifying environment novelty by leveraging the student's state-action space coverage from previous curriculum experiences. We then propose an implementation of CENIE that models this coverage and measures environment novelty using Gaussian Mixture Models. By integrating both regret and novelty as complementary objectives for curriculum design, CENIE facilitates effective exploration across the state-action space while progressively increasing curriculum complexity. Empirical evaluations demonstrate that augmenting existing regret-based UED algorithms with CENIE achieves state-of-the-art performance across multiple benchmarks, underscoring the effectiveness of novelty-driven autocurricula for robust generalization.

AAMAS Conference 2024 Conference Paper

Unifying Regret and State-Action Space Coverage for Effective Unsupervised Environment Design

  • Jayden Teoh Jing Teoh
  • Wenjun Li
  • Pradeep Varakantham

Unsupervised Environment Design (UED) employs interactive training between a teacher agent and a student agent to train generallycapable student agents. Existing UED methods primarily rely on regret to progressively introduce curriculum complexity for the student but often overlook the importance of environment novelty — a critical element for enhancing an agent’s exploration and generalization capabilities. There is a substantial lack of investigating the effects of environment novelty in UED. This paper addresses this gap by introducing the GMM-based Evaluation of Novelty In Environments (GENIE) framework. GENIE quantifies environment novelty within the UED paradigm by using Gaussian Mixture Models. To assess GENIE’s effectiveness in quantifying novelty and driving exploration, we integrate it with ACCEL, the state-ofthe-art UED algorithm. Empirical results demonstrate the superior zero-shot performance of this extended approach over existing UED algorithms, including its predecessor. By providing a means to quantify environment novelty, GENIE lays the groundwork for future UED algorithms to unify novelty-driven exploration and regret-driven exploitation in curriculum generation.

AAAI Conference 2024 Conference Paper

Unsupervised Training Sequence Design: Efficient and Generalizable Agent Training

  • Wenjun Li
  • Pradeep Varakantham

To train generalizable Reinforcement Learning (RL) agents, researchers recently proposed the Unsupervised Environment Design (UED) framework, in which a teacher agent creates a very large number of training environments and a student agent trains on the experiences in these environments to be robust against unseen testing scenarios. For example, to train a student to master the “stepping over stumps” task, the teacher will create numerous training environments with varying stump heights and shapes. In this paper, we argue that UED neglects training efficiency and its need for very large number of environments (henceforth referred to as infinite horizon training) makes it less suitable to training robots and non-expert humans. In real-world applications where either creating new training scenarios is expensive or training efficiency is of critical importance, we want to maximize both the learning efficiency and learning outcome of the student. To achieve efficient finite horizon training, we propose a novel Markov Decision Process (MDP) formulation for the teacher agent, referred to as Unsupervised Training Sequence Design (UTSD). Specifically, we encode salient information from the student policy (e.g., behaviors and learning progress) into the teacher's state space, enabling the teacher to closely track the student's learning progress and consequently discover the optimal training sequences with finite lengths. Additionally, we explore the teacher's efficient adaptation to unseen students at test time by employing the context-based meta-learning approach, which leverages the teacher's past experiences with various students. Finally, we empirically demonstrate our teacher's capability to design efficient and effective training sequences for students with varying capabilities.

IJCAI Conference 2023 Conference Paper

Generalization through Diversity: Improving Unsupervised Environment Design

  • Wenjun Li
  • Pradeep Varakantham
  • Dexun Li

Agent decision making using Reinforcement Learning (RL) heavily relies on either a model or simulator of the environment (e. g. , moving in an 8x8 maze with three rooms, playing Chess on an 8x8 board). Due to this dependence, small changes in the environment (e. g. , positions of obstacles in the maze, size of the board) can severely affect the effectiveness of the policy learned by the agent. To that end, existing work has proposed training RL agents on an adaptive curriculum of environments (generated automatically) to improve performance on out-of-distribution (OOD) test scenarios. Specifically, existing research has employed the potential for the agent to learn in an environment (captured using Generalized Advantage Estimation, GAE) as the key factor to select the next environment(s) to train the agent. However, such a mechanism can select similar environments (with a high potential to learn) thereby making agent training redundant on all but one of those environments. To that end, we provide a principled approach to adaptively identify diverse environments based on a novel distance measure relevant to environment design. We empirically demonstrate the versatility and effectiveness of our method in comparison to multiple leading approaches for unsupervised environment design on three distinct benchmark problems used in literature.

TCS Journal 2022 Journal Article

A 5k-vertex kernel for P2-packing

  • Wenjun Li
  • Junjie Ye
  • Yixin Cao

The P 2 -packing problem asks whether a graph contains k vertex-disjoint (not necessarily induced) paths each of length two. We continue the study of its kernelization algorithms, and develop a 5k-vertex kernel.

TCS Journal 2022 Journal Article

A divide-and-conquer approach for reconstruction of {C≥5}-free graphs via betweenness queries

  • Guozhen Rong
  • Yongjie Yang
  • Wenjun Li
  • Jianxin Wang

We study the query complexity of reconstructing { C ≥ 5 } -free graphs with respect to the betweenness oracle. In particular, we show that hidden { C ≥ 5 } -free graphs can be reconstructed by using O ( Δ 14 ⋅ log 2 ⁡ n + Δ 9 ⋅ n log 2 ⁡ n ) betweenness queries in expectation, where Δ denotes the maximum degree of the given graph and n denotes the number of vertices. In addition, we propose two improved randomized algorithms for two subclasses of { C ≥ 5 } -free graphs, namely the distance-hereditary graphs and the chordal graphs. For the former class, our algorithm uses O ( Δ 10 ⋅ log 2 ⁡ n + Δ 5 ⋅ n log 2 ⁡ n ) betweenness queries in expectation, and for the latter class, our algorithm uses O ( Δ 2 ⋅ n log 2 ⁡ n ) betweenness queries in expectation.

TCS Journal 2022 Journal Article

Improved kernel and algorithm for claw and diamond free edge deletion based on refined observations

  • Wenjun Li
  • Huan Peng
  • Yongjie Yang

In the Image 1 -Free Edge Deletion problem (CDFED), we are given a graph G and an integer k > 0, and the question is whether there are at most k edges whose deletion results in a graph without claws and diamonds as induced subgraphs. Based on some refined observations, we propose a kernel of O ( k 3 ) vertices and O ( k 4 ) edges, significantly improving the previous kernel of O ( k 12 ) vertices and O ( k 24 ) edges. In addition, we derive an O ⁎ ( 3. 792 k ) -time algorithm for CDFED.

TCS Journal 2021 Journal Article

A (2 + ϵ)k-vertex kernel for the dual coloring problem

  • Wenjun Li
  • Yang Ding
  • Yongjie Yang
  • Guozhen Rong

Given a graph G of n vertices and an integer k, the Dual Coloring problem determines if G is ( n − k ) -colorable, i. e. , if we can color vertices of G with at most n − k colors so that every vertex obtains exactly one color and every two adjacent vertices have different colors. We derive a kernelization for the Dual Coloring problem with respect to the parameter k. In particular, for any fixed ϵ > 0, our kernelization yields a kernel of at most ( 2 + ϵ ) k vertices, improving the currently best result 3 k − 3.

TCS Journal 2021 Journal Article

Reconstruction and verification of chordal graphs with a distance oracle

  • Guozhen Rong
  • Wenjun Li
  • Yongjie Yang
  • Jianxin Wang

A hidden graph is a graph whose edge set is hidden. A distance oracle of a graph G is a black-box that receives two vertices of G and outputs the distance between the two vertices. Given a hidden graph, the reconstruction problem aims to identify the edges of the hidden graph by accessing a distance oracle, and the verification problem aims to check whether the hidden graph is equal to another given graph (not hidden). If the hidden graph G is a connected chordal graph, a Las Vegas reconstruction algorithm using O ( Δ 3 2 Δ ⋅ n ( 2 Δ + log 2 ⁡ n ) log ⁡ n ) distance queries is known, where Δ is the maximum degree of G and n is the number of vertices of G. Improving upon this result, we present a reconstruction algorithm using only O ( Δ 2 n log 2 ⁡ n ) distance queries. As a byproduct, we obtain a deterministic algorithm for the verification of chordal graphs with O ( Δ 2 n log ⁡ n ) distance queries. Additionally, we derive a deterministic algorithm of reconstructing connected interval graphs using only O ( Δ n ) distance queries, and prove that reconstructing or verifying a connected interval graph needs Ω ( Δ n ) distance queries, which implies that this algorithm is the best possible in terms of the number of distance queries needed.

TCS Journal 2019 Journal Article

An improved linear kernel for complementary maximal strip recovery: Simpler and smaller

  • Wenjun Li
  • Haiyan Liu
  • Jianxin Wang
  • Lingyun Xiang
  • Yongjie Yang

We study the Complementary Maximal Strip Recovery problem (CMSR), where the given are two strings S 1 and S 2 of distinct letters, each of which appears either in the positive form or the negative form. The question is whether there are k letters whose deletion results in two matched strings. String S 1 matches string S 2 if there are partitions of S 1 and S 2 such that each component of the partitions contains at least two letters and, moreover, for each component S 1 i of the partition of S 1, there is a unique component S 2 j in the partition of S 2 which is either equal to S 1 i or can be obtained from S 1 i by firstly reversing the order of the letters and then negating the letters. The CMSR problem is known to be NP-hard and fixed-parameter tractable with respect to k. In particular, a linear kernel of size 74 k + 4 was developed based on 8 reduction rules. Very recently, by imposing 3 new reduction rules to the previous kernelization, the linear kernel has been improved to 58k. We aim to simplify the kernelization, yet obtain an improved kernel. In particular, we study 7 reduction rules which lead to a linear kernel of size 42 k + 24.

IJCAI Conference 2019 Conference Paper

Resolution and Domination: An Improved Exact MaxSAT Algorithm

  • Chao Xu
  • Wenjun Li
  • Yongjie Yang
  • Jianer Chen
  • Jianxin Wang

We study the Maximum Satisfiability problem (MaxSAT). Particularly, we derive a branching algorithm of running time O*(1. 2989^m) for the MaxSAT problem, where m denotes the number of clauses in the given CNF formula. Our algorithm considerably improves the previous best result O*(1. 3248^m) by Chen and Kanj [2004] published 15 years ago. For our purpose, we derive improved branching strategies for variables of degrees 3, 4, and 5. The worst case of our branching algorithm is at variables of degree 4 which occur twice both positively and negatively in the given CNF formula. To serve the branching rules and shrink the size of the CNF formula, we also propose a variety of reduction rules which can be exhaustively applied in polynomial time and, moreover, some of them solve a bottleneck of the previous best algorithm.

TCS Journal 2018 Journal Article

A 2k-kernelization algorithm for vertex cover based on crown decomposition

  • Wenjun Li
  • Binhai Zhu

We revisit crown decomposition for the Vertex Cover problem by giving a simple 2k-kernelization algorithm. Previously, a 2k kernel was known but it was computed using both crown decomposition and linear programming; moreover, with crown decomposition alone only a 3k kernel was known. Our refined crown decomposition carries some extra property and could be used for some other related problems.

TCS Journal 2018 Journal Article

On the kernelization of split graph problems

  • Yongjie Yang
  • Yash Raj Shrestha
  • Wenjun Li
  • Jiong Guo

A split graph is a graph whose vertices can be partitioned into a clique and an independent set. We study numerous problems on split graphs, namely the k -Vertex-Disjoint Paths, k -Cycle, k -Path and k - ℓ -Stable Set problems. In the k -Vertex-Disjoint Paths problem, we are given a graph and k terminal pairs of vertices, and are asked whether there is a set of k vertex-disjoint paths linking these terminal pairs, respectively. In the k -Cycle/k -Path problem, we are given a graph and are asked whether there is a path/cycle of length k. The k - ℓ -Stable Set problem takes a graph and an integer k as input, and asks whether the graph has a subset of k vertices such that the distance between every two vertices in the subset is at least ℓ + 1. It is known that all the above problems are NP-complete on split graphs. We derive a 4k-vertex kernel for the k -Vertex-Disjoint Paths problem and an O ( k 2 ) -vertex kernel for both the k -Path problem and the k -Cycle problem. Concerning the k - ℓ -Stable Set problem, for ℓ = 1 or ℓ ≥ 3, the problem is polynomial-time solvable on split graphs. For ℓ = 2, we prove that the k - ℓ -Stable Set problem is W[1]-complete on split graphs, with respect to k. However, if the given split graph contains no K 1, r as an induced subgraph, and every vertex in the independent set of the split graph has degree at most d, we derive a linear vertex kernel for the k -2-Stable Set problem, where both r and d are constants.

I&C Journal 2017 Journal Article

Deeper local search for parameterized and approximation algorithms for maximum internal spanning tree

  • Wenjun Li
  • Yixin Cao
  • Jianer Chen
  • Jianxin Wang

The maximum internal spanning tree problem asks for a spanning tree of a given graph that has the maximum number of internal vertices among all spanning trees of this graph. In its parameterized version, we are interested in whether the graph has a spanning tree with at least k internal vertices. Fomin et al. (2013) [4] crafted a very ingenious reduction rule, and showed that a simple application of this rule is sufficient to yield a 3k-vertex kernel, implying an O ⁎ ( 8 k ) -time parameterized algorithm. Using depth-2 local search, Knauer and Spoerhase (2015) [9] developed a (5/3)-approximation algorithm for the optimization version. We try deeper local search: We conduct a thorough combinatorial analysis on the obtained spanning trees and explore their algorithmic consequences. We first observe that from the spanning tree obtained by depth-3 local search, one can easily find a reducible structure and apply the reduction rule of Fomin et al. This gives an improved kernel of 2k vertices, and as a by-product, a deterministic algorithm running in time O ⁎ ( 4 k ). We then go even deeper by considering the spanning tree obtained by depth-5 local search. It is shown that the number of internal vertices of this spanning tree is at least 2/3 of the maximum number a spanning tree can have, thereby delivering an improved approximation algorithm with ratio 1. 5 for the problem.

TCS Journal 2017 Journal Article

Improved kernel results for some FPT problems based on simple observations

  • Wenjun Li
  • Qilong Feng
  • Jianer Chen
  • Shuai Hu

In this paper, we study the kernelization algorithms for several parameterized problems, including Parameterized Co-Path Set problem, Parameterized Path-Contractibility problem and Parameterized Connected Dominating Set on G 7 Graphs problem. Based on simple observations, we give simple kernelization algorithms with kernel sizes 4k, 3 k + 4, and O ( k 2 ), respectively, which improves the previous best results 6k, 5 k + 3, and O ( k 3 ), respectively.

TCS Journal 2017 Journal Article

Partition on trees with supply and demand: Kernelization and algorithms

  • Mugang Lin
  • Qilong Feng
  • Jianer Chen
  • Wenjun Li

Network reconfiguration is an important research topic in the planning and operation of power distribution networks. In this paper, we study the partition problem on trees with supply and demand from parameterized computation perspective. We analyze the relationship between supply nodes and demand nodes, and give four reduction rules, which result in a kernel of size O ( k 2 ) for the problem. Based on branching technique, a parameterized algorithm of running time O ⁎ ( 2. 828 k ) is presented.

YNIMG Journal 2015 Journal Article

Nature of functional links in valuation networks differentiates impulsive behaviors between abstinent heroin-dependent subjects and nondrug-using subjects

  • Tianye Zhai
  • Yongcong Shao
  • Gang Chen
  • Enmao Ye
  • Lin Ma
  • Lubin Wang
  • Yu Lei
  • Guangyu Chen

Advanced neuroimaging studies have identified brain correlates of pathological impulsivity in a variety of neuropsychiatric disorders. However, whether and how these spatially separate and functionally integrated neural correlates collectively contribute to aberrant impulsive behaviors remains unclear. Building on recent progress in neuroeconomics toward determining a biological account of human behaviors, we employed resting-state functional MRI to characterize the nature of the links between these neural correlates and to investigate their impact on impulsivity. We demonstrated that through functional connectivity with the ventral medial prefrontal cortex, the δ-network (regions of the executive control system, such as the dorsolateral prefrontal cortex) and the β-network (regions of the reward system involved in the mesocorticolimbic pathway), jointly influence impulsivity measured by the Barratt impulsiveness scale scores. In control nondrug-using subjects, the functional link between the β- and δ-networks is balanced, and the δ-network competitively controls impulsivity. However, in abstinent heroin-dependent subjects, the link is imbalanced, with stronger β-network connectivity and weaker δ-network connectivity. The imbalanced link is associated with impulsivity, indicating that the β- and δ-networks may mutually reinforce each other in abstinent heroin-dependent subjects. These findings of an aberrant link between the β- and δ-networks in abstinent heroin-dependent subjects may shed light on the mechanism of aberrant behaviors of drug addiction and may serve as an endophenotype to mark individual subjects' self-control capacity.

ICRA Conference 2014 Conference Paper

Design optimization and comparison of magneto-rheological actuators

  • Wenjun Li
  • Peyman Yadmellat
  • Mehrdad R. Kermani

In this paper, an optimization method for designing MR clutches is studied. The proposed method optimizes the geometrical dimensions of an MR clutch, hence its mass, for given output torque and electrical input power. The main idea behind this optimization is that the input power and output torque are two parameters that are normally known to the designer prior to the design of an MR clutch and considering these parameters in the optimization as fixed values has a practical significance. Having presented the optimization method, we compare the characteristics of three different MR clutch configurations in order to demonstrate the effectiveness of the proposed method. A comparison between the drum, single-disk and multi-disk configurations of MR clutches is performed. Using the proposed method one can select a suitable configuration as well as the geometrical dimensions for an MR clutch that best suits the requirements of each individual design.

ICRA Conference 2014 Conference Paper

Linear torque actuation using FPGA-controlled Magneto-Rheological actuators

  • Wenjun Li
  • Peyman Yadmellat
  • Mehrdad R. Kermani

In recent years, Magneto-Rheological (MR) clutches have been increasingly used for realizing compliant actuation. One difficulty in using MR clutches is the existence of nonlinear hysteretic behaviors between the input current and output torque of an MR clutch. In this paper, a new closed-loop, Field-Programable-Gate-Array (FPGA) based control scheme to linearize an MR clutch's input-output relationship is presented. The feedback signal used in this control scheme is the magnetic field acquired from hall sensors within the MR clutch. The FPGA board uses this feedback signal to compensate for the nonlinear behavior of the MR clutch using an estimated model of the clutch magnetic field. The local use of an FPGA board will dramatically simplify the use of MR clutches for torque actuation. The effectiveness of the proposed technique is validated using an experimental platform that includes an MR clutch as part of a compliant actuation mechanism. The results clearly demonstrate that the use of the FPGA based closed-loop control scheme can effectively eliminate hysteretic behaviors of the MR clutch, allowing to have linear actuators with predictable behaviors.

YNICL Journal 2013 Journal Article

Late-life depression, mild cognitive impairment and hippocampal functional network architecture

  • Chunming Xie
  • Wenjun Li
  • Gang Chen
  • B. Douglas Ward
  • Malgorzata B. Franczak
  • Jennifer L. Jones
  • Piero G. Antuono
  • Shi-Jiang Li

Late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are associated with medial temporal lobe structural abnormalities. However, the hippocampal functional connectivity (HFC) similarities and differences related to these syndromes when they occur alone or coexist are unclear. Resting-state functional connectivity MRI (R-fMRI) technique was used to measure left and right HFC in 72 elderly participants (LLD [n = 18], aMCI [n = 17], LLD with comorbid aMCI [n = 12], and healthy controls [n = 25]). The main and interactive relationships of LLD and aMCI on the HFC networks were determined, after controlling for age, gender, education and gray matter volumes. The effects of depressive symptoms and episodic memory deficits on the hippocampal functional connections also were assessed. While increased and decreased left and right HFC with several cortical and subcortical structures involved in mood regulation were related to LLD, aMCI was associated with globally diminished connectivity. Significant LLD-aMCI interactions on the right HFC networks were seen in the brain regions critical for emotion processing and higher-order cognitive functions. In the interactive brain regions, LLD and aMCI were associated with diminished hippocampal functional connections, whereas the comorbid group demonstrated enhanced connectivity. Main and interactive effects of depressive symptoms and episodic memory performance were also associated with bilateral HFC network abnormalities. In conclusion, these findings indicate that discrete hippocampal functional network abnormalities are associated with LLD and aMCI when they occur alone. However, when these conditions coexist, more pronounced vulnerabilities of the hippocampal networks occur, which may be a marker of disease severity and impending cognitive decline. By utilizing R-fMRI technique, this study provides novel insights into the neural mechanisms underlying LLD and aMCI in the functional network level.

YNIMG Journal 2012 Journal Article

A clustering-based method to detect functional connectivity differences

  • Gang Chen
  • B. Douglas Ward
  • Chunming Xie
  • Wenjun Li
  • Guangyu Chen
  • Joseph S. Goveas
  • Piero G. Antuono
  • Shi-Jiang Li

Recently, resting-state functional magnetic resonance imaging (R-fMRI) has emerged as a powerful tool for investigating functional brain organization changes in a variety of neurological and psychiatric disorders. However, the current techniques may need further development to better define the reference brain networks for quantifying the functional connectivity differences between normal and diseased subject groups. In this study, we introduced a new clustering-based method that can clearly define the reference clusters. By employing group difference information to guide the clustering, the voxels within the reference clusters will have homogeneous functional connectivity changes above predefined levels. This method identified functional clusters that were significantly different between the amnestic mild cognitively impaired (aMCI) and age-matched cognitively normal (CN) subjects. The results indicated that the distribution of the clusters and their functionally disconnected regions resembled the altered memory network regions previously identified in task fMRI studies. In conclusion, the new clustering method provides an advanced approach for studying functional brain organization changes associated with brain diseases.

YNIMG Journal 2012 Journal Article

Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment

  • Chunming Xie
  • Feng Bai
  • Hui Yu
  • Yongmei Shi
  • Yonggui Yuan
  • Gang Chen
  • Wenjun Li
  • Guangyu Chen

Abnormalities of functional connectivity in the default mode network (DMN) recently have been reported in patients with amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) or other psychiatric diseases. As such, these abnormalities may be epiphenomena instead of playing a causal role in AD progression. To date, few studies have investigated specific brain networks, which extend beyond the DMN involved in the early AD stages, especially in aMCI. The insula is one site affected by early pathological changes in AD and is a crucial hub of the human brain networks. Currently, we explored the contribution of the insula networks to cognitive performance in aMCI patients. Thirty aMCI and 26 cognitively normal (CN) subjects participated in this study. Intrinsic connectivity of the insula networks was measured, using the resting-state functional connectivity fMRI approach. We examined the differential connectivity of insula networks between groups, and the neural correlation between the altered insula networks connectivity and the cognitive performance in aMCI patients and CN subjects, respectively. Insula subregional volumes were also investigated. AMCI subjects, when compared to CN subjects, showed significantly reduced right posterior insula volumes, cognitive deficits and disrupted intrinsic connectivity of the insula networks. Specifically, decreased intrinsic connectivity was primarily located in the frontal–parietal network and the cingulo-opercular network, including the anterior prefrontal cortex (aPFC), anterior cingulate cortex, operculum, inferior parietal cortex and precuneus. Increased intrinsic connectivity was primarily situated in the visual–auditory pathway, which included the posterior superior temporal gyrus and middle occipital gyrus. Conjunction analysis was performed; and significantly decreased intrinsic connectivity in the overlapping regions of the anterior and posterior insula networks, including the bilateral aPFC, left dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and anterior temporal pole was found. Furthermore, the disrupted intrinsic connectivity was associated with episodic memory (EM) deficits in the aMCI patients and not in the CN subjects. These findings demonstrated that the functional integration of the insula networks plays an important role in the EM process. They provided new insight into the neural mechanism underlying the memory deficits in aMCI patients.

YNIMG Journal 2012 Journal Article

Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment

  • Wenjun Li
  • Piero G. Antuono
  • Chunming Xie
  • Gang Chen
  • Jennifer L. Jones
  • B. Douglas Ward
  • Malgorzata B. Franczak
  • Joseph S. Goveas

Acetylcholinesterase inhibitors (AChEIs), such as donepezil, have been shown to improve cognition in mild to moderate Alzheimer's disease (AD) patients. In this paper, our goal is to determine the relationship between altered cerebral blood flow (CBF) and intrinsic functional network connectivity changes in mild AD patients before and after 12-week donepezil treatment. An integrative neuroimaging approach was employed by combining pseudocontinuous arterial spin labeling (pCASL) MRI and resting-state functional MRI (R-fMRI) methods to determine the changes in CBF and functional connectivity (FC) in the cholinergic pathway. Linear regression analyses determined the correlations of the regional CBF alterations and functional connectivity changes with cognitive responses. These were measured with the Mini-Mental Status Examination (MMSE) scores and Alzheimer's disease Assessment Scale-Cognitive subscale (ADAS-cog) scores. Our results show that the regional CBF in mild AD subjects after donepezil treatment was significantly increased in the middle cingulate cortex (MCC) and posterior cingulate cortex (PCC), which are the neural substrates of the medial cholinergic pathway. In both brain regions, the baseline CBF and its changes after treatment were significantly correlated with the behavioral changes in ADAS-cog scores. The intrinsic FC was significantly enhanced in the medial cholinergic pathway network in the brain areas of the parahippocampal, temporal, parietal and prefrontal cortices. Finally, the FC changes in the medial prefrontal areas demonstrated an association with the CBF level in the MCC and the PCC, and also were correlated with ADAS-cog score changes. These findings indicate that regional CBF and FC network changes in the medial cholinergic pathway were associated with cognitive performance. It also is suggested that the combined pCASL-MRI and R-fMRI methods could be used to detect regional CBF and FC changes when using drug treatments in mild AD subjects.

TCS Journal 2010 Journal Article

A parameterized algorithm for the hyperplane-cover problem

  • Jianxin Wang
  • Wenjun Li
  • Jianer Chen

We consider the problem of covering a given set of points in the Euclidean space R m by a small number k of hyperplanes of dimensions bounded by d, where d ≤ m. We present a very simple parameterized algorithm for the problem, and give thorough mathematical analysis to prove the correctness and derive the complexity of the algorithm. When the algorithm is applied on the standard hyperplane-cover problem in R d, it runs in time O ∗ ( k ( d − 1 ) k / 1. 3 k ), improving the previous best algorithm of running time O ∗ ( k d k + d ) for the problem. When the algorithm is applied on the line-cover problem in R 2, it runs in time O ∗ ( k k / 1. 3 5 k ), improving the previous best algorithm of running time O ∗ ( k 2 k / 4. 8 4 k ) for the problem.

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