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Timothy Piton

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

2 papers

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YNICL Journal 2026 Journal Article

Cognitive adaptations for memory deficits in MCI and AD patients: A meta-analysis of EEG microstates

Timothy Piton
Una Smailovic
Vesna Jelic
Thomas Koenig
Paul G. Unschuld
Lucie Bréchet

AIM: EEG microstate analysis enables the exploration of the brain's neuronal network activity associated with distinct mental states and cognitive functions in neurodegenerative conditions, such as Alzheimer's disease (AD). Some studies indicated that AD and patients with mild cognitive impairments (MCI) show a reduced presence of microstate C, which is related to self-related memory functions and mind-wandering and involves brain areas of the default mode network (DMN). However, other studies reported an increased presence of microstate A, which is associated with auditory/language functions. Here, we aimed to systematically investigate alterations in the four canonical EEG microstates (A, B, C, and D) in MCI and AD patients compared to healthy older adults. METHODS: We performed a meta-analysis that compared microstate temporal parameters - mean duration, occurrence rate, and time coverage - among MCI and AD patients and healthy older adults. We included 12 experimental studies that examined resting-state, eyes-closed EEG microstate parameters in 1347 participants (448 MCI patients, 514 AD patients, and 385 healthy controls). RESULTS: We found thatAD patients showed increased duration and time coverage of microstate A and increased duration of microstate B, while the occurrence of microstates C and D was reduced. MCI patients also exhibited increased duration, occurrence, and time coverage of microstate A, while all three parameters of microstate D were reduced compared to healthy controls. CONCLUSION: These results suggest that MCI and AD patients suffer from disruption in their cognitive control, memory, and self-referential processes. They may compensate for these deficits by verbalizing and visualizing their inner thoughts to maintain cognitive engagement.

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YNIMG Journal 2022 Journal Article

Breathing is coupled with voluntary initiation of mental imagery

Hyeong-Dong Park
Timothy Piton
Oliver A. Kannape
Niall W. Duncan
Kang-Yun Lee
Timothy J. Lane
Olaf Blanke

Previous research has suggested that bodily signals from internal organs are associated with diverse cortical and subcortical processes involved in sensory-motor functions, beyond homeostatic reflexes. For instance, a recent study demonstrated that the preparation and execution of voluntary actions, as well as its underlying neural activity, are coupled with the breathing cycle. In the current study, we investigated whether such breathing-action coupling is limited to voluntary motor action or whether it is also present for mental actions not involving any overt bodily movement. To answer this question, we recorded electroencephalography (EEG), electromyography (EMG), and respiratory signals while participants were conducting a voluntary action paradigm including self-initiated motor execution (ME), motor imagery (MI), and visual imagery (VI) tasks. We observed that the voluntary initiation of ME, MI, and VI are similarly coupled with the respiration phase. In addition, EEG analysis revealed the existence of readiness potential (RP) waveforms in all three tasks (i.e., ME, MI, VI), as well as a coupling between the RP amplitude and the respiratory phase. Our findings show that the voluntary initiation of both imagined and overt action is coupled with respiration, and further suggest that the breathing system is involved in preparatory processes of voluntary action by contributing to the temporal decision of when to initiate the action plan, regardless of whether this culminates in overt movements.

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