Author name cluster

Suixue Wang

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

6 papers

1 author row

AAAI Conference 2026 Conference Paper

SAMGTD: Spatial-Aware Masked Graph Transformer-Diffusion Model for Enhanced Cell Type Deconvolution in Spatial Transcriptomics

Shilin Zhang
Suixue Wang
Qingchen Zhang
Xiulong Liu

Recent advances in spatial transcriptomics have enabled the integration of gene expression profiles with precise spatial coordinates, which have facilitated the exploration of tumor occurrence and development mechanisms, as well as the development of more effective targeted and immunotherapy approaches for tumor treatment. Deciphering cell type represents a critical challenge in spatial transcriptomics research. Existing methods are limited by the pervasive “dropout” events in spatial transcriptomics, hindering their ability to fully capture the relationship between spatial location and gene expression, thereby compromising the performance of cell type deconvolution. To address these limitations, we propose a spatial-aware masked graph transformer-diffusion model (SAMGTD) for enhanced cell type deconvolution in spatial transcriptomics. For spatial transcriptomics, the masked graph transformer model is designed to adaptively capture complex dependencies between spatial locations and gene expression. It employs a masking strategy that guides the model to focus on important local information during training, while the multi-head attention mechanism captures global context. More importantly, the spatial diffusion model is constructed to achieve the dual enhancement of spatial transcriptomics, including denoising and data imputation. It incorporates the multi-head attention mechanism and residual blocks, effectively addressing the “dropout” issue commonly encountered in spatial transcriptomics. For scRNA-seq, we construct a variational autoencoder to reduce noise interference while preserving key gene expression information. Finally, we construct a spatial-aware contrastive learning model to integrate scRNA-seq and spatial transcriptomics for cell type deconvolution. Experiments conducted on three datasets demonstrate that SAMGTD outperforms baseline methods.

PDF Details DOI

AAAI Conference 2026 Conference Paper

SSL-CST: Cell Segmentation for Single-Cell Spatial Transcriptome Based on Self-Supervised Learning

Weiliang Huo
Shilin Zhang
Suixue Wang
Qingchen Zhang

The continuous advancements in life science technology have enabled spatial transcriptome technology to achieve an impressive level of resolution at the single-cell level. This technology has emerged as a crucial method for studying the cellular composition and differentiation states of tissues, investigating cell-cell interactions, and unraveling the molecular mechanisms underlying diseases and developmental processes. A key component in this analysis is the accurate segmentation of cells. However, existing segmentation methods often fail to fully leverage the valuable information provided by spatial transcriptomics, leading to inaccurate cell segmentation. In this study, we introduce SSL-CST, a cell segmentation for single-cell spatial transcriptome method based on self-supervised learning. SSL-CST employs a pre-trained model for foundational contour segmentation. Following the denoising process, it utilizes a self-supervised neural network to correct the cell boundaries to obtain accurate cell boundaries. Through this approach, SSL-CST outperforms other state-of-the-art methods in various tests conducted on multiple datasets. The improved segmentation provided by SSL-CST further enhances the analysis of single-cell spatial expression, providing effective tools for biological discovery.

PDF Details DOI

IJCAI Conference 2025 Conference Paper

CSF-GAN: Cross-modal Semantic Fusion-based Generative Adversarial Network for Text-guided Image Inpainting

Shilin Zhang
Suixue Wang
Qingchen Zhang
Liang Zhao
Weiliang Huo
Sijia Hou
Chunjiang Fu

Most visual-guided image inpainting methods based on generative adversarial networks (GANs) struggle when the missing region has weak correlations with the surrounding visual context. Recently, diffusion-based methods guided by textual context have been proposed to address this limitation by leveraging additional semantic information to restore corrupted objects. However, these models typically involve more parameters and exhibit slower generation speeds compared to GAN-based approaches. To address this problem, we propose a novel text-guided image inpainting model, the cross-modal semantic fusion generative adversarial network (CSF-GAN). CSF-GAN is designed as a one-stage GAN with the following key contributions. First, a novel semantic fusion module (SFM) is introduced to integrate sentence- and word-level textual context into the inpainting process, enabling more effective guidance from multi-granularity semantic information. Second, a newly designed word-level local discriminator provides detailed feedback to the generator, enhancing the accuracy of generated content in alignment with word-level semantics. Third, two loss functions, the inpainting loss and edge loss, are employed to enhance both structural coherence and textural realism in the generated results. Extensive experiments on two benchmark datasets demonstrate that CSF-GAN outperforms state-of-the-art methods.

PDF Details DOI

IJCAI Conference 2025 Conference Paper

Higher-order Logical Knowledge Representation Learning

Suixue Wang
Weiliang Huo
Shilin Zhang
Qingchen Zhang

Real-world knowledge graphs abound with higher-order logical relations that simple triples, limited to pairwise connections, fail to represent. Thus, capturing higher-order logical relations involving multiple entities has garnered significant attention. However, existing methods ignore the structural information in higher-order relations. To this end, we propose a higher-order logical knowledge representation learning method, named LORE, which leverages network motifs, the patterns/subgraphs that naturally capture the structural information in graphs, to extract higher-order features and ultimately, learn effective representations of knowledge graphs. Compared to existing approaches, LORE aggregates the attribute features of entities with the extracted higher-order logical relations to form enhanced representations of knowledge graphs. In particular, three aggregators (i. e. , Hadamard, Connection, and Summation) are proposed and employed. Extensive experiments have been conducted on six real-world datasets for two downstream tasks (i. e. , entity classification and link prediction). The results show that LORE outperforms baselines significantly and consistently.

PDF Details DOI

IJCAI Conference 2025 Conference Paper

MASTER: A Multi-granularity Invariant Structure Clustering Scheme for Multi-view Clustering

Suixue Wang
Shilin Zhang
Qingchen Zhang
Peng Li
Weiliang Huo

Deep multi-view clustering has attracted increasing attention in the pattern mining of data. However, most of them perform self-learning mechanisms in a single space, ignoring the fruitful structural information hidden in different-level feature spaces. Meanwhile, they conduct the reconstruction constraint to learn generalized representations of samples, failing to explore the discriminative ability of complementary and consistent information. To address the challenges, a multi-granularity invariant structure clustering scheme (MASTER) is proposed to define a bottom-up process that extracts multi-level information in sample, neighborhood, and category granularities from low-level, high-level, and semantics feature space, respectively. Specifically, it leverages the self-learning reconstruction with information-theoretic overclustering to capture invariant sample structure in the low-level feature space. Then, it models data diffusion of the clustering process in the reliable neighborhood to capture invariant local structure in the high-level feature space. Meanwhile, it defines dual divergences induced by the space geometry to capture invariant global structure in the semantics space. Finally, extensive experiments on 8 real-world datasets show that MASTER achieves state-of-the-art performance compared to 11 baselines.

PDF Details DOI

IJCAI Conference 2025 Conference Paper

POMP: Pathology-omics Multimodal Pre-training Framework for Cancer Survival Prediction

Suixue Wang
Shilin Zhang
Huiyuan Lai
Weiliang Huo
Qingchen Zhang

Cancer survival prediction is an important direction in precision medicine, aiming to help clinicians tailor treatment regimens for patients. With the rapid development of high-throughput sequencing and computational pathology technologies, survival prediction has shifted from clinical features to joint modeling of multi-omics data and pathology images. However, existing multimodal learning methods struggle to effectively learn pathology-omics interactions due to the lack of proper alignment of multimodal data before fusion. In this paper, we propose POMP, a pathology-omics multimodal pre-training framework jointly learned with three training tasks for integrating pathological images and omics data for cancer survival prediction. To better perform cross-modal learning, we introduce a pathology-omics contrastive learning method to align the pathology and omics information. POMP leverages the principle of pre-trained models and explores the benefit of aligning multimodal information from the same patient, achieving state-of-the-art results on six cancer datasets from the Cancer Genome Atlas (TCGA). We also show that our contrastive learning method allows us to exploit the cosine similarity of pathological images and omics data as the survival risk score, which can further boost prediction performance compared with other commonly used methods. The code is available at https: //github. com/SuixueWang/POMP.

PDF Details DOI