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Soyoung Choi

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5 papers
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5

NeurIPS Conference 2025 Conference Paper

MIDAS: Misalignment-based Data Augmentation Strategy for Imbalanced Multimodal Learning

  • Seong-Hyeon Hwang
  • Soyoung Choi
  • Steven Whang

Multimodal models often over-rely on dominant modalities, failing to achieve optimal performance. While prior work focuses on modifying training objectives or optimization procedures, data-centric solutions remain underexplored. We propose MIDAS, a novel data augmentation strategy that generates misaligned samples with semantically inconsistent cross-modal information, labeled using unimodal confidence scores to compel learning from contradictory signals. However, this confidence-based labeling can still favor the more confident modality. To address this within our misaligned samples, we introduce weak-modality weighting, which dynamically increases the loss weight of the least confident modality, thereby helping the model fully utilize weaker modality. Furthermore, when misaligned features exhibit greater similarity to the aligned features, these misaligned samples pose a greater challenge, thereby enabling the model to better distinguish between classes. To leverage this, we propose hard-sample weighting, which prioritizes such semantically ambiguous misaligned samples. Experiments on multiple multimodal classification benchmarks demonstrate that MIDAS significantly outperforms related baselines in addressing modality imbalance.

YNIMG Journal 2024 Journal Article

White matter engagement in brain networks assessed by integration of functional and structural connectivity

  • Muwei Li
  • Kurt G Schilling
  • Lyuan Xu
  • Soyoung Choi
  • Yurui Gao
  • Zhongliang Zu
  • Adam W Anderson
  • Zhaohua Ding

Current models of brain networks may potentially be improved by integrating our knowledge of structural connections, within and between circuits, with metrics of functional interactions between network nodes. The former may be obtained from diffusion MRI of white matter (WM), while the latter may be derived by measuring correlations between resting state BOLD signals from pairs of gray matter (GM) regions. From inspection of diffusion MRI data, it is clear that each WM voxel within a 3D image array may be traversed by multiple WM structural tracts, each of which connects a pair of GM nodes. We hypothesized that by appropriately weighting and then integrating the functional connectivity of each such connected pair, the overall engagement of any WM voxel in brain functions could be evaluated. This model introduces a structural constraint to earlier studies of WM engagement and addresses some limitations of previous efforts to relate structure and function. Using concepts derived from graph theory, we obtained spatial maps of WM engagement which highlight WM regions critical for efficient communications across the brain. The distributions of WM engagement are highly reproducible across subjects and depict a notable interdependence between the distribution of GM activities and the detailed organization of WM. Additionally, we provide evidence that the engagement varies over time and shows significant differences between genders. These findings suggest the potential of WM engagement as a measure of the integrity of normal brain functions and as a biomarker for neurological and cognitive disorders.

YNIMG Journal 2018 Journal Article

Are you thinking what I'm thinking? Synchronization of resting fMRI time-series across subjects

  • Anand A. Joshi
  • Minqi Chong
  • Jian Li
  • Soyoung Choi
  • Richard M. Leahy

We describe BrainSync, an orthogonal transform that allows direct comparison of resting fMRI (rfMRI) time-series across subjects. For this purpose, we exploit the geometry of the rfMRI signal space to propose a novel orthogonal transformation that synchronizes rfMRI time-series across sessions and subjects. When synchronized, rfMRI signals become approximately equal at homologous locations across subjects. The method is based on the observation that rfMRI data exhibit similar connectivity patterns across subjects, as reflected in the pairwise correlations between different brain regions. We show that if the data for two subjects have similar correlation patterns then their time courses can be approximately synchronized by an orthogonal transformation. This transform is unique, invertible, efficient to compute, and preserves the connectivity structure of the original data for all subjects. Analogously to image registration, where we spatially align structural brain images, this temporal synchronization of brain signals across a population, or within-subject across sessions, facilitates cross-sectional and longitudinal studies of rfMRI data. The utility of the BrainSync transform is illustrated through demonstrative simulations and applications including quantification of rfMRI variability across subjects and sessions, cortical functional parcellation across a population, timing recovery in task fMRI data, comparison of task and resting state data, and an application to complex naturalistic stimuli for annotation prediction.

YNICL Journal 2017 Journal Article

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients

  • Soyoung Choi
  • Adam M. Bush
  • Matthew T. Borzage
  • Anand A. Joshi
  • William J. Mack
  • Thomas D. Coates
  • Richard M. Leahy
  • John C. Wood

Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic systemic and cerebral vascular disease that leads to early and cumulative neurological damage. Few studies have quantified the effects of this disease on brain morphometry and even fewer efforts have been devoted to older patients despite the progressive nature of the disease. This study quantifies global and regional brain volumes in adolescent and young adult patients with SCD and racially matched controls with the aim of distinguishing between age related changes associated with normal brain maturation and damage from sickle cell disease. T1 weighted images were acquired on 33 clinically asymptomatic SCD patients (age=21. 3±7. 8; F=18, M=15) and 32 racially matched control subjects (age=24. 4±7. 5; F=22, M=10). Exclusion criteria included pregnancy, previous overt stroke, acute chest, or pain crisis hospitalization within one month. All brain volume comparisons were corrected for age and sex. Globally, grey matter volume was not different but white matter volume was 8. 1% lower (p=0. 0056) in the right hemisphere and 6. 8% (p=0. 0068) in the left hemisphere in SCD patients compared with controls. Multivariate analysis retained hemoglobin (β=0. 33; p=0. 0036), sex (β=0. 35; p=0. 0017) and mean platelet volume (β=0. 27; p=0. 016) as significant factors in the final prediction model for white matter volume for a combined r2 of 0. 37 (p<0. 0001). Lower white matter volume was confined to phylogenetically younger brain regions in the anterior and middle cerebral artery distributions. Our findings suggest that there are diffuse white matter abnormalities in SCD patients, especially in the frontal, parietal and temporal lobes, that are associated with low hemoglobin levels and mean platelet volume. The pattern of brain loss suggests chronic microvascular insufficiency and tissue hypoxia as the causal mechanism. However, longitudinal studies of global and regional brain morphometry can help us give further insights on the pathophysiology of SCD in the brain.

YNIMG Journal 2015 Journal Article

Co-registration and distortion correction of diffusion and anatomical images based on inverse contrast normalization

  • Chitresh Bhushan
  • Justin P. Haldar
  • Soyoung Choi
  • Anand A. Joshi
  • David W. Shattuck
  • Richard M. Leahy

Diffusion MRI provides quantitative information about microstructural properties which can be useful in neuroimaging studies of the human brain. Echo planar imaging (EPI) sequences, which are frequently used for acquisition of diffusion images, are sensitive to inhomogeneities in the primary magnetic (B0) field that cause localized distortions in the reconstructed images. We describe and evaluate a new method for correction of susceptibility-induced distortion in diffusion images in the absence of an accurate B0 fieldmap. In our method, the distortion field is estimated using a constrained non-rigid registration between an undistorted T1-weighted anatomical image and one of the distorted EPI images from diffusion acquisition. Our registration framework is based on a new approach, INVERSION (Inverse contrast Normalization for VERy Simple registratION), which exploits the inverted contrast relationship between T1- and T2-weighted brain images to define a simple and robust similarity measure. We also describe how INVERSION can be used for rigid alignment of diffusion images and T1-weighted anatomical images. Our approach is evaluated with multiple in vivo datasets acquired with different acquisition parameters. Compared to other methods, INVERSION shows robust and consistent performance in rigid registration and shows improved alignment of diffusion and anatomical images relative to normalized mutual information for non-rigid distortion correction.

v2026.09.13