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Signy Sheldon

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4 papers

1 author row

YNIMG Journal 2022 Journal Article

Volume of the posterior hippocampus mediates age-related differences in spatial context memory and is correlated with increased activity in lateral frontal, parietal and occipital regions in healthy aging

Jamie Snytte
Can Fenerci
Sricharana Rajagopal
Camille Beaudoin
Kiera Hooper
Signy Sheldon
Rosanna K. Olsen
M. Natasha Rajah

Healthy aging is associated with episodic memory decline, particularly in the ability to encode and retrieve object-context associations (context memory). Neuropsychological and neuroimaging studies have highlighted the importance of the medial temporal lobes (MTL) in supporting episodic memory across the lifespan. However, given the functional heterogeneity of the MTL, volumetric declines in distinct regions may impact performance on specific episodic memory tasks, and affect the function of the large-scale neurocognitive networks supporting episodic memory encoding and retrieval. In the current study, we investigated how MTL structure may mediate age-related differences in performance on spatial and temporal context memory tasks, in a sample of 125 healthy adults aged 19-76 years old. Standard T1-weighted MRIs were segmented into the perirhinal, entorhinal and parahippocampal cortices, as well as the anterior and posterior hippocampal subregions. We observed negative linear and quadratic associations between age and volume of the parahippocampal cortex, and anterior and posterior hippocampal subregions. We also found that volume of the posterior hippocampus fully mediated the association between age and spatial, but not temporal context memory performance. Further, we employed a multivariate behavior partial-least-squares analysis to assess how age and regional MTL volumes correlated with brain activity during the encoding and retrieval of spatial context memories. We found that greater activity within lateral prefrontal, parietal, and occipital regions, as well as within the anterior MTL was related to older age and smaller volume of the posterior hippocampus. Our results highlight the heterogeneity of MTL contributions to episodic memory across the lifespan and provide support for the posterior-anterior shift in aging, and scaffolding theory of aging and cognition.

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YNICL Journal 2020 Journal Article

Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease

Marianne Chapleau
Christophe Bedetti
Gabriel A. Devenyi
Signy Sheldon
Howie J. Rosen
Bruce L. Miller
Maria Luisa Gorno-Tempini
Mallar M. Chakravarty

BACKGROUND: Increasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease (AD). METHODS: We measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit. RESULTS: Comparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus. DISCUSSION: Our study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA.

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YNIMG Journal 2019 Journal Article

Retrieval orientation alters neural activity during autobiographical memory recollection

Lauri Gurguryan
Signy Sheldon

When an autobiographical memory is retrieved, the underlying memory representation is constructed by flexibly activating a broad neural network. As such, the content used to reconstruct a memory can bias activity within this neural network. Here, we tested the hypothesis that focusing on the conceptual and contextual aspects of a memory to construct a memory representation will recruit distinct neural subsystems. To test this hypothesis, we measured neural activity as participants retrieved memories under retrieval orientations that biased remembering towards these elements of a past autobiographical experience. In an MRI scanner, participants first retrieved autobiographical memories and then were re-oriented towards the conceptual or contextual elements of that memory. They then used this re-oriented content (conceptual or contextual elements) to access and elaborate upon a new autobiographical memory. Confirming our hypothesis, we found a neural dissociation between these retrieval orientation conditions that aligned with established models of memory. We also found evidence that this neural dissociation was most prominent when the re-oriented mnemonic content was used to access a new memory. Altogether, the reported results provide critical insight into how and when retrieval orientations alter neural support for autobiographical memory retrieval and inform on the neural organization of autobiographical knowledge.

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YNIMG Journal 2013 Journal Article

Same as it ever was: Vividness modulates the similarities and differences between the neural networks that support retrieving remote and recent autobiographical memories

Signy Sheldon
Brian Levine

The comparison of recent and remote autobiographical memories is often confounded by qualitative disparities across memories of different ages, such as vividness. In this study, ten individuals prospectively collected audio recordings that were used to cue memories of recent (~1month old) and remote (~1. 5year old) everyday events. Because the retrieval cues were recorded at the time of event, they were highly potent. Although remote events did not differ in novelty, importance, or emotional change at the time at the time of encoding, half of the cues for these events induced retrieval comparable in vividness to recent events (all of which were vividly re-experienced). Recent and remote vivid memories were associated with a neural pattern that included right frontal, left parietal and limbic regions that were active early in the retrieval period. Non-vivid remote memories were associated with a later onset of a bilateral distributed pattern that included regions in the frontal, parietal, and temporal lobes. Functional connectivity analysis indicated that the left anterior hippocampus was co-activated with bilateral frontal, parahippocampal, and parietal regions for vivid memories (irrespective of memory age) early in the retrieval period, whereas non-vivid memories, alongside recent memories, showed later and broader co-activation with frontal, parietal, occipital, and temporal regions. The absence of a significant difference between the recent and remote vivid memories may be due to insufficient power to detect potential subtle differences between these conditions. Nonetheless, there was evidence for different patterns of hippocampal–neocortical connectivity for remote memories and recent memories, irrespective of vividness. These findings suggest that while there is a functional shift in hippocampal connectivity that is associated with memory age when very recent events are used, vividness is strongly associated with both activation and functional connectivity patterns irrespective of memory age.

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