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Ruonan Wang

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8 papers
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8

TMLR Journal 2026 Journal Article

DRAW: Domain Weight Randomization with Bayesian Updating for LLM Pre-Training

  • Ruonan Wang
  • Yongqi Qiao
  • Zhonglin Xie
  • Kun Yuan

Optimal pre-training data mixture is pivotal for large language model (LLM) performance, but searching for the best domain weights is computationally expensive. We present Domain Weight Randomization with Bayesian Updating (DRAW), a principled framework treating domain weights as Dirichlet-distributed random variables whose parameters scale with model width. Informative priors are first estimated using proxy models; the main model then refines these using Bayesian inference and parameter scaling, dynamically sampling domain weights during training. Theoretically, DRAW reduces generalization error at a rate $\mathcal{O}(1/\sqrt{n})$ as model width increases, ensuring stable convergence. Empirical results on open-domain corpora and diverse benchmarks show DRAW reliably outperforms fixed and adaptive baselines in both language modeling and downstream tasks, achieving better average and worst-case performance alongside strong robustness. DRAW not only highlights valuable data domains while suppressing noisy ones, but also introduces a scalable and effective mechanism for adaptive data mixing in LLM pre-training, facilitating efficient knowledge transfer from proxy to large models.

YNIMG Journal 2026 Journal Article

VSSI-TBM: A variational sparse source imaging method based on time basis matrix

  • Tianyu Gao
  • Jin Ding
  • Wen Li
  • Fulong Wang
  • Yujie Ma
  • Ruonan Wang
  • Yang Gao
  • Xiaolin Ning

Source imaging algorithms have been widely used to localize functional and lesion areas. Brain source reconstruction is limited by complex experimental environments (noise interference, distributed brain activity, acquisition systems, etc.), and range estimation is not accurate. This study proposes a variational sparse source imaging method based on the time basis matrix (VSSI-TBM) algorithm. VSSI-TBM permits the source spatial signal to consist of several temporal basis functions by using low-rank decomposition to extract effective signals. In a compressed space, mixed-norm constraints and a cortical source variation operator ensure spatial sparsity and smoothness. In clinical examinations or research, other a priori information regarding brain activity may be available. VSSI-TBM using lead field guide constraints can further enhance the reconstruction results. The simulation results demonstrate the robust performance of VSSI-TBM in environments with a low signal-to-noise ratio (SNR), large sources ( > 11 cm 2 ), and multiple sources. Additionally, integrating prior information enhances the imaging performance in complex environments. The algorithm is evaluated using an open-source dataset and an optically pumped magnetometer-based magnetoencephalography (OPM-MEG) system with a noisy 30-channel uniform layout. The results reveal a strong robustness of the spatial range reconstruction. Moreover, the combination of prior information effectively improves the imaging performance of the OPM-MEG system.

YNIMG Journal 2025 Journal Article

Extended homogeneous field correction method based on oblique projection in OPM-MEG

  • Fulong Wang
  • Fuzhi Cao
  • Yujie Ma
  • Ruochen Zhao
  • Ruonan Wang
  • Nan An
  • Min Xiang
  • Dawei Wang

Optically pumped magnetometer-based magnetoencephalography (OPM-MEG) is an novel non-invasive functional imaging technique that features more flexible sensor configurations and wearability; however, this also increases the requirement for environmental noise suppression. Subspace projection algorithms are widely used in MEG to suppress noise. However, in OPM-MEG systems with a limited number of channels, subspace projection methods that rely on spatial oversampling exhibit reduced performance. The homogeneous field correction (HFC) method resolves this problem by constructing a low-rank spatial model; however, it cannot address complex non-homogeneous noise. The spatiotemporal extended homogeneous field correction (teHFC) method uses multiple orthogonal projections to suppress disturbances. However, the signal and noise subspace are not completely orthogonal, limiting enhancement in the capabilities of the teHFC. Therefore, we propose an extended homogeneous field correction method based on oblique projection (opHFC), which overcomes the issue of non-orthogonality between the signal and noise subspace, enhancing the ability to suppress complex interferences. The opHFC constructs an oblique projection operator that divides the signals into internal and external components, eliminating complex interferences through temporal extension. We compared the opHFC with four benchmark methods by simulations and auditory and somatosensory evoked OPM-MEG experiments. The results demonstrate that opHFC provides superior noise suppression with minimal distortion, enhancing the signal quality at the sensor and source levels. Our method offers a novel approach to reducing interference in OPM-MEG systems, expanding their application scenarios, and providing high-quality signals for scientific research and clinical applications based on OPM-MEG.

YNIMG Journal 2025 Journal Article

Noise and artifact suppression in SQUID and wearable OPM-MEG: A systematic review of background, physiological, and Technical interference

  • Ruonan Wang
  • Yujie Ma
  • Ruochen Zhao
  • Jin Ding
  • Ling Li
  • Yanfei Yang
  • Fulong Wang
  • Zhiqiang Cao

Magnetoencephalography (MEG) is a non-invasive imaging technique that captures neural activity with high spatio-temporal resolution. In recent years, novel wearable devices based on Optically Pumped Magnetometer (OPM) have emerged as a new driving force for advancing MEG due to their cost-effectiveness, portability, and mobility. In practical applications, MEG signals are frequently influenced by various interference sources, resulting in degradation of signal quality. Consequently, numerous suppression techniques have been proposed to overcome these challenges. This manuscript presents a comprehensive review of the most advanced methods for suppressing MEG noise or artifacts, with a specific focus on mitigating background noise, physiological artifacts (such as those caused by heartbeat, eye movements, and muscle contractions), as well as technical artifacts (including system-related artifacts associated with devices, motion-induced artifacts, and metal-induced artifacts). Additionally, the current limitations and challenges of these approaches in real-world scenarios are highlighted. Reviewing nearly a decade of research, there is an urgent need for a lightweight noise analysis framework in the complex measurement environment of wearable OPM-MEG devices. This framework should be capable of effectively detecting, classifying, and suppressing individual and combined MEG interference. By addressing this need, we can enhance the reliability and practicality of MEG signals while advancing brain science research.

YNIMG Journal 2025 Journal Article

Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG

  • Fulong Wang
  • Yujie Ma
  • Tianyu Gao
  • Yue Tao
  • Ruonan Wang
  • Ruochen Zhao
  • Fuzhi Cao
  • Yang Gao

The optically pumped magnetometer (OPM) based magnetoencephalography (MEG) system offers advantages such as flexible layout and wearability. However, the position instability or jitter of OPM sensors can result in bad channels and segments, which significantly impede subsequent preprocessing and analysis. Most common methods directly reject or interpolate to repair these bad channels and segments. Direct rejection leads to data loss, and when the number of sensors is limited, interpolation using neighboring sensors can cause significant signal distortion and cannot repair bad segments present in all channels. Therefore, most existing methods are unsuitable for OPM-MEG systems with fewer channels. We introduce an automatic bad segments and bad channels repair method for OPM-MEG, called Repairbads. This method aims to repair all bad data and reduce signal distortion, especially capable of automatically repairing bad segments present in all channels simultaneously. Repairbads employs Riemannian Potato combined with joint decorrelation to project out artifact components, achieving automatic bad segment repair. Then, an adaptive algorithm is used to segment the signal into relatively stable noise data chunks, and the source-estimate-utilizing noise-discarding algorithm is applied to each chunk to achieve automatic bad channel repair. We compared the performance of Repairbads with the Autoreject method on both simulated and real auditory evoked data, using five evaluation metrics for quantitative assessment. The results demonstrate that Repairbads consistently outperforms across all five metrics. In both simulated and real OPM-MEG data, Repairbads shows better performance than current state-of-the-art methods, reliably repairing bad data with minimal distortion. The automation of this method significantly reduces the burden of manual inspection, promoting the automated processing and clinical application of OPM-MEG.

YNIMG Journal 2024 Journal Article

Expanding the clinical application of OPM-MEG using an effective automatic suppression method for the dental brace metal artifact

  • Ruonan Wang
  • Kaiwen Fu
  • Ruochen Zhao
  • Dawei Wang
  • Zhimin Yang
  • Wei Bin
  • Yang Gao
  • Xiaolin Ning

Optically pumped magnetometer magnetoencephalography (OPM-MEG) holds significant promise for clinical functional brain imaging due to its superior spatiotemporal resolution. However, effectively suppressing metallic artifacts, particularly from devices such as orthodontic braces and vagal nerve stimulators remains a major challenge, hindering the wider clinical application of wearable OPM-MEG devices. A comprehensive analysis of metal artifact characteristics from time, frequency, and time-frequency perspectives was conducted for the first time using an OPM-MEG device in clinical medicine. This study focused on patients with metal orthodontics, examining the modulation of metal artifacts by breath and head movement, the incomplete regular sub-Gaussian distribution, and the high absolute power ratio in the 0.5-8 Hz band. The existing metal artifact suppression algorithms applied to SQUID-MEG, such as fast independent component analysis (FastICA), information maximization (Infomax), and algorithms for multiple unknown signal extraction (AMUSE), exhibit limited efficacy. Consequently, this study introduced the second-order blind identification (SOBI) algorithm, which utilized multiple time delays for the component separation of OPM-MEG measurement signals. We modified the time delays of the SOBI method to improve its efficacy in separating artifact components, particularly those in the ultralow frequency range. This approach employs the frequency-domain absolute power ratio, root mean square (RMS) value, and mutual information methods to automate the artifact component screening process. The effectiveness of this method was validated through simulation experiments involving four subjects in both resting and evoked experiments. In addition, the proposed method was also validated by the actual OPM-MEG evoked experiments of three subjects. Comparative analyses were conducted against the FastICA, Infomax, and AMUSE algorithms. Evaluation metrics included normalized mean square error, normalized delta band power error, RMS error, and signal-to-noise ratio, demonstrating that the proposed method provides optimal suppression of metal artifacts. This advancement holds promise for enhancing data quality and expanding the clinical applications of OPM-MEG.

YNIMG Journal 2018 Journal Article

Abnormal frontostriatal tracts in young male tobacco smokers

  • Kai Yuan
  • Dahua Yu
  • Meng Zhao
  • Min Li
  • Ruonan Wang
  • Yangding Li
  • Peter Manza
  • Ehsan Shokri-Kojori

Dysfunctions in frontostriatal circuits have been associated with craving and cognitive control in smokers. However, the relevance of white matter (WM) diffusion properties of the ventral and dorsal frontostriatal tracts for behaviors associated with smoking remains relatively unknown, especially in young adulthood, a critical time period for the development and maintenance of addiction. Here, diffusion tensor imaging (DTI) and probabilistic tractography were used to investigate the WM tracts of the ventral and dorsal frontostriatal circuits in two independent studies (Study1: 36 male smokers (21. 3 ± 1. 3 years) vs. 35 male nonsmokers (21. 2 ± 1. 3 years); Study2: 29 male smokers (21. 4 ± 1. 1 years) vs. 25 male nonsmokers (21. 0 ± 1. 4 years)). Subjective craving was measured by the Questionnaire on Smoking Urges (QSU) and cognitive control ability was assessed with the Stroop task. In both studies, smokers committed more response errors than nonsmokers during the incongruent condition of the Stroop task. Relative to controls, smokers showed lower fractional anisotropy (FA) and higher radial diffusivity in left medial orbitofrontal cortex-to-nucleus accumbens fiber tracts (ventral frontostriatal path) and also lower FA in right dorsolateral prefrontal cortex-to-caudate fiber tracts (dorsal frontostriatal path). The FA values of the right dorsal fibers were negatively correlated with incongruent response Stroop errors in smokers, whereas the mean diffusivity values of the left ventral fibers were positively correlated with craving in smokers. Thus, WM diffusion properties of the dorsal and ventral frontostriatal tracts were associated with cognitive control and craving, respectively, in young male tobacco smokers. These data highlight the importance of studying WM in relation to neuropsychological changes underlying smoking.

v2026.09.13