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Qintong Li

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6 papers

2 author rows

AAAI Conference 2026 Conference Paper

RMSAGen: Integrating Multiple Sequence Alignment for Function RNA Design

Jiyue Jiang
Yanyu Chen
Qingchuan Zhang
Jiayi Li
Xiangyu Shi
Chang Zhou
Ziqian Lin
Jiuming Wang

Biological sequences, including RNAs and proteins, share similarities with natural languages, enabling the application of advanced language models to various biological tasks. However, due to its flexibility and lack of experimental data, RNA is a particularly challenging biological ``language'' compared to other biological sequences like proteins. RNA multiple sequence alignments (MSAs), which align evolutionarily related RNA sequences, can greatly enhance RNA biology modeling, as evidenced by their significant roles in structure prediction and function annotation. This raises the question of whether RNA MSAs can also benefit RNA design, which remains unexplored. This paper introduces RMSAGen, a model comprising RMSA-Encoder and RMSA-Decoder, that leverages MSAs to design functional RNA sequences. RMSA-Encoder effectively extracts MSA features, enhancing performance in functional prediction and solvent accessibility prediction tasks and supporting RMSA-Decoder in accurate RNA generation. RMSAGen can design RNA sequences that effectively bind to target RNA-binding proteins, and the design performance improves with an increasing number of sequences. In addition, the ribozymes designed with structural features by RMSAGen show strong computational metrics and exhibit biological activity during gel electrophoresis. These results highlight the effectiveness of RMSAGen, establishing it as a powerful tool and a new direction for RNA design.

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NeurIPS Conference 2025 Conference Paper

Activation-Guided Consensus Merging for Large Language Models

Yuxuan Yao
Shuqi LIU
Zehua Liu
Qintong Li
Mingyang Liu
Xiongwei Han
Zhijiang Guo
Han Wu

Recent research has increasingly focused on reconciling the reasoning capabilities of System 2 with the efficiency of System 1. While existing training-based and prompt-based approaches face significant challenges in terms of efficiency and stability, model merging emerges as a promising strategy to integrate the diverse capabilities of different Large Language Models (LLMs) into a unified model. However, conventional model merging methods often assume uniform importance across layers, overlooking the functional heterogeneity inherent in neural components. To address this limitation, we propose \textbf{A}ctivation-Guided \textbf{C}onsensus \textbf{M}erging (\textbf{ACM}), a plug-and-play merging framework that determines layer-specific merging coefficients based on mutual information between activations of pre-trained and fine-tuned models. ACM effectively preserves task-specific capabilities without requiring gradient computations or additional training. Extensive experiments on Long-to-Short (L2S) and general merging tasks demonstrate that ACM consistently outperforms all baseline methods. For instance, in the case of Qwen-7B models, TIES-Merging equipped with ACM achieves a \textbf{55. 3\%} reduction in response length while simultaneously improving reasoning accuracy by \textbf{1. 3} points. We submit the code with the paper for reproducibility, and it will be publicly available.

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NeurIPS Conference 2025 Conference Paper

DynaAct: Large Language Model Reasoning with Dynamic Action Spaces

Xueliang Zhao
Wei Wu
Jian Guan
Qintong Li
Lingpeng Kong

In modern sequential decision-making systems, the construction of an optimal candidate action space is critical to efficient inference. However, existing approaches either rely on manually defined action spaces that lack scalability or utilize unstructured spaces that render exhaustive search computationally prohibitive. In this paper, we propose a novel framework named \textsc{DynaAct} for automatically constructing a compact action space to enhance sequential reasoning in complex problem-solving scenarios. Our method first estimates a proxy for the complete action space by extracting general sketches observed in a corpus covering diverse complex reasoning problems using large language models. We then formulate a submodular function that jointly evaluates candidate actions based on their utility to the current state and their diversity, and employ a greedy algorithm to select an optimal candidate set. Extensive experiments on six diverse standard benchmarks demonstrate that our approach significantly improves overall performance, while maintaining efficient inference without introducing substantial latency. The implementation is available at \url{https: //github. com/zhaoxlpku/DynaAct}.

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ICLR Conference 2025 Conference Paper

Forewarned is Forearmed: Harnessing LLMs for Data Synthesis via Failure-induced Exploration

Qintong Li
Jiahui Gao
Sheng Wang
Renjie Pi
Xueliang Zhao
Chuan Wu
Xin Jiang
Zhenguo Li

Large language models (LLMs) have significantly benefited from training on diverse, high-quality task-specific data, leading to impressive performance across a range of downstream applications. Current methods often rely on human-annotated data or predefined task templates to direct powerful LLMs in synthesizing task-relevant data for effective model training. However, this dependence on manually designed components may constrain the scope of generated data, potentially overlooking critical edge cases or novel scenarios that could challenge the model. In this paper, we present a novel approach, ReverseGen, designed to automatically generate effective training samples that expose the weaknesses of LLMs. Specifically, we introduce a dedicated proposer trained to produce queries that lead target models to generate unsatisfactory responses. These failure-inducing queries are then used to construct training data, helping to address the models' shortcomings and improve overall performance. Our approach is flexible and can be applied to models of various scales (3B, 7B, and 8B). We evaluate ReverseGen on three key applications—safety, honesty, and math—demonstrating that our generated data is both highly effective and diverse. Models fine-tuned with ReverseGen-generated data consistently outperform those trained on human-annotated or general model-generated data, offering a new perspective on data synthesis for task-specific LLM enhancement.

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NeurIPS Conference 2025 Conference Paper

TreeSynth: Synthesizing Diverse Data from Scratch via Tree-Guided Subspace Partitioning

Sheng Wang
Pengan CHEN
Jingqi Zhou
Qintong Li
Jingwei Dong
Jiahui Gao
Boyang XUE
Jiyue Jiang

Model customization necessitates high-quality and diverse datasets, but acquiring such data remains time-consuming and labor-intensive. Despite the great potential of large language models (LLMs) for data synthesis, current approaches are constrained by limited seed data, model biases and low-variation prompts, resulting in limited diversity and biased distribution with the increase of data scales. To tackle this challenge, we introduce TreeSynth, a tree-guided subspace-based data synthesis approach inspired by decision trees. It constructs a spatial partitioning tree to recursively divide a task-specific full data space (i. e. , root node) into numerous atomic subspaces (i. e. , leaf nodes) with mutually exclusive and exhaustive attributes to ensure both distinctiveness and comprehensiveness, before synthesizing samples within each atomic subspace. This globally divide-and-synthesize method finally collects subspace samples into a comprehensive dataset, effectively circumventing repetition and space collapse to ensure the diversity of large-scale data synthesis. Furthermore, the spatial partitioning tree enables sample allocation into atomic subspaces, allowing the re-balancing of existing datasets for more balanced and comprehensive distributions. Empirically, extensive experiments across diverse benchmarks consistently validates the superior data diversity, model performance, and robust scalability of TreeSynth compared to both human-crafted datasets and peer data synthesis methods, with the average performance gain reaching 10%. Besides, the consistent improvements of TreeSynth-balanced datasets highlight its efficacious application to redistribute existing datasets for more comprehensive coverage and the induced performance enhancement. The code is available at https: //github. com/cpa2001/TreeSynth.

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AAAI Conference 2022 Conference Paper

Knowledge Bridging for Empathetic Dialogue Generation

Qintong Li
Piji Li
Zhaochun Ren
Pengjie Ren
Zhumin Chen

Lack of external knowledge makes empathetic dialogue systems difficult to perceive implicit emotions and learn emotional interactions from limited dialogue history. To address the above problems, we propose to leverage external knowledge, including commonsense knowledge and emotional lexical knowledge, to explicitly understand and express emotions in empathetic dialogue generation. We first enrich the dialogue history by jointly interacting with external knowledge and construct an emotional context graph. Then we learn emotional context representations from the knowledge-enriched emotional context graph and distill emotional signals, which are the prerequisites to predicate emotions expressed in responses. Finally, to generate the empathetic response, we propose an emotional cross-attention mechanism to learn the emotional dependencies from the emotional context graph. Extensive experiments conducted on a benchmark dataset verify the effectiveness of the proposed method. In addition, we find the performance of our method can be further improved by integrating with a pre-trained model that works orthogonally.

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