EAAI Journal 2026 Journal Article
Identifying non-small cell lung cancer subtypes by a hybrid representative causal network with computed tomography images
- Li Liu
- Xueying Wang
- Shanshan Huang
- Zhengqiao Deng
- Shu Wang
- Guang Wu
- Donglai Yang
- Sixi Zha
Identifying representative causal features from computed tomography (CT) images remains a significant challenge for the subtype classification of non-small cell lung cancer (NSCLC). Existing methods, whether based on radiomics or deep neural networks, often overlook the intricate causal relationships among features, thereby yielding suboptimal or even detrimental diagnostic outcomes. To bridge this gap, we propose a Hybrid Representative Causal Network (HRCL) for NSCLC subtype identification, which explicitly captures the local causal relationships inherent in the interaction between radiomics and features based on deep learning from a holistic perspective. Specifically, a causal network structure is learned to delineate the unique causal configuration of distinct NSCLC subtypes through a variable number of nodes and links. The resultant network adheres to the causal Markov property, thereby ensuring global consistency of all local cause–effect dependencies. Moreover, a hybrid representative feature selector is designed to identify the most salient causal features from the causal network for precise NSCLC subtype classification. Our method achieves an accuracy of 83. 7% on the publicly available P-NSCLC dataset and 90. 3% on the privately collected I-NSCLC dataset. The empirical evaluations demonstrate that our model significantly outperforms the state-of-the-art methods.