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Ping Wu

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EAAI Journal 2025 Journal Article

FA-SconvAE-LSTM: Feature-Aligned Stacked Convolutional Autoencoder with Long Short-Term Memory Network for Soft Sensor Modeling

  • Ping Wu
  • Zengdi Miao
  • Ke Wang
  • Jinfeng Gao
  • Xujie Zhang
  • Siwei Lou
  • Chunjie Yang

The advancement of soft sensor technology has enabled the real-time estimation of critical parameters in complex industrial processes, where direct measurement through hardware sensors is often infeasible. Industrial process data typically exhibit both spatial correlations and temporal dependencies, necessitating sophisticated modeling approaches to capture these characteristics effectively. In this study, a spatio-temporal model, termed the feature-aligned stacked convolutional autoencoder with long short-term memory, is proposed to develop soft sensors for nonlinear dynamic industrial processes. The proposed model begins with the systematic training of a stacked convolutional autoencoder using a layer-by-layer pre-training technique. This approach facilitates the extraction of high-level spatial feature representations from the process variables. To address the issue of feature misalignment in the spatial features extracted by the stacked convolutional autoencoder, a feature alignment strategy is implemented, ensuring that the extracted spatial features are properly aligned. Subsequently, the aligned spatial features are fed into a long short-term memory network to capture temporal dependencies, with quality variables serving as the output for soft sensor development. The effectiveness and superiority of the proposed method are demonstrated through experiments conducted on two industrial processes: the sulfur recovery unit and the multiphase flow process. Comparative analyses with other state-of-the-art methods reveal that the proposed model achieves the highest performance, with R 2 values of 0. 86222 for the sulfur recovery unit and 0. 94307 for the multiphase flow process, outperforming all compared methods.

YNICL Journal 2023 Journal Article

The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease

  • Jiaying Lu
  • Zhengwei Zhang
  • Ping Wu
  • Xiaoniu Liang
  • Huiwei Zhang
  • Jimin Hong
  • Christoph Clement
  • Tzu-Chen Yen

PURPOSE: Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity. METHODS: F-Florzolotau]. Based on the absolute global tau interhemispheric differences, each cohort was divided into two groups (asymmetric versus symmetric tau distribution). The two groups were cross-sectionally compared in terms of demographic, cognitive characteristics, and pathological burden. The cognitive decline trajectories were analyzed longitudinally. RESULTS: Fourteen (23.3%) and 42 (48.3%) patients in the ADNI and SMS cohorts showed an asymmetric tau distribution, respectively. An asymmetric tau distribution was associated with an earlier age at disease onset (proportion of early-onset AD: ADNI/SMS/combined cohorts, p = 0.093/0.026/0.001) and more severe pathological burden (i.e., global tau burden: ADNI/SMS cohorts, p < 0.001/= 0.007). And patients with an asymmetric tau distribution were characterized by a steeper cognitive decline longitudinally (i.e., the annual decline of Mini-Mental Status Examination score: ADNI/SMS/combined cohorts, p = 0.053 / 0.035 / < 0.001). CONCLUSIONS: Asymmetry in tau deposition, which may be associated with an earlier age at onset, more severe pathological burden, and a steeper cognitive decline, is potentially an important characteristic of AD heterogeneity.

YNICL Journal 2020 Journal Article

Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder

  • Xianhua Han
  • Ping Wu
  • Ian Alberts
  • Hucheng Zhou
  • Huan Yu
  • Panagiotis Bargiotas
  • Igor Yakushev
  • Jian Wang

OBJECTIVE: F-FDG reveals metabolic perturbations, which are scored by spatial covariance analysis. However, the resultant pattern scores do not capture the spatially heterogeneous trajectories of metabolic changes between individual brain regions. Assuming metabolic progression occurs as a continuum from the healthy control (HC) condition to iRBD and then PD, we investigated spatial dynamics of progressively perturbed glucose metabolism in a cross-sectional study. METHODS: F-FDG uptake and the Unified Parkinson's Disease Rating Scale motor (UPDRS III) scores in the PD group. RESULTS: F-FDG metabolism and disease duration in the iRBD group. Regional hyper- and hypo-metabolism in the PD patients correlated with disease duration or clinical UPDRS III scores. CONCLUSION: Cerebral metabolism changes heterogeneously in a continuum extending from HC to iRBD and PD groups in this preliminary study. The distinctive metabolic trajectories point towards a potential neuroimaging biomarker for conversion of iRBD to frank PD, which should be amenable to advanced pattern recognition analysis in future longitudinal studies.

YNICL Journal 2020 Journal Article

Reproducible metabolic topographies associated with multiple system atrophy: Network and regional analyses in Chinese and American patient cohorts

  • Bo Shen
  • Sidi Wei
  • Jingjie Ge
  • Shichun Peng
  • Fengtao Liu
  • Ling Li
  • Sisi Guo
  • Ping Wu

PURPOSE: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome and often difficult to discriminate clinically from progressive supranuclear palsy (PSP) and Parkinson's disease (PD) in early stages. Although a characteristic metabolic brain network has been reported for MSA, it is unknown whether this network can provide a clinically useful biomarker in different centers. This study was aimed to identify and cross-validate MSA-related brain network and assess its ability for differential diagnosis and clinical correlations in Chinese and American patient cohorts. METHODS: F-FDG PET scans retrospectively from 128 clinically diagnosed parkinsonian patients (34 MSA, 34 PSP and 60 PD) and 40 normal subjects in China and in the USA. Using PET images from 20 moderate-stage MSA patients of parkinsonian subtype and 20 normal subjects in both centers, we reproduced MSA-related pattern (MSAPRP) of spatial covariance and estimated its reliability. MSAPRP scores were evaluated in assessing differential diagnosis among moderate- and early-stage MSA, PSP or PD patients and clinical correlations with disease severity. Regional metabolic differences were detected using statistical parameter mapping analysis. MSA-related network and regional topographies of metabolic abnormality were cross-validated between the Chinese and American cohorts. RESULTS: We generated a highly reliable MSAPRP characterized by decreased loading in inferior frontal cortex, striatum and cerebellum, and increased loading in sensorimotor, parietal and occipital cortices. MSAPRP scores discriminated between normal, MSA, PSP and PD subjects and correlated with standardized ratings of clinical stages and motor symptoms in MSA. High similarities in MSAPRPs, network scores and corresponding maps of metabolic abnormality were observed between two different cohorts. CONCLUSION: We have demonstrated reproducible metabolic topographies associated with MSA at both network and regional levels in two independent patient cohorts. Moreover, MSAPRP scores are sensitive for evaluating disease discrimination and clinical correlates. This study supports differential diagnosis of MSA regardless of different patient populations, PET scanners and imaging protocols.

YNIMG Journal 2017 Journal Article

Data-driven identification of intensity normalization region based on longitudinal coherency of 18F-FDG metabolism in the healthy brain

  • Huiwei Zhang
  • Ping Wu
  • Sibylle I. Ziegler
  • Yihui Guan
  • Yuetao Wang
  • Jingjie Ge
  • Markus Schwaiger
  • Sung-Cheng Huang

Objectives In brain 18F-FDG PET data intensity normalization is usually applied to control for unwanted factors confounding brain metabolism. However, it can be difficult to determine a proper intensity normalization region as a reference for the identification of abnormal metabolism in diseased brains. In neurodegenerative disorders, differentiating disease-related changes in brain metabolism from age-associated natural changes remains challenging. This study proposes a new data-driven method to identify proper intensity normalization regions in order to improve separation of age-associated natural changes from disease related changes in brain metabolism. Methods 127 female and 128 male healthy subjects (age: 20 to 79) with brain18F-FDG PET/CT in the course of a whole body cancer screening were included. Brain PET images were processed using SPM8 and were parcellated into 116 anatomical regions according to the AAL template. It is assumed that normal brain 18F-FDG metabolism has longitudinal coherency and this coherency leads to better model fitting. The coefficient of determination R2 was proposed as the coherence coefficient, and the total coherence coefficient (overall fitting quality) was employed as an index to assess proper intensity normalization strategies on single subjects and age-cohort averaged data. Age-associated longitudinal changes of normal subjects were derived using the identified intensity normalization method correspondingly. In addition, 15 subjects with clinically diagnosed Parkinson's disease were assessed to evaluate the clinical potential of the proposed new method. Results Intensity normalizations by paracentral lobule and cerebellar tonsil, both regions derived from the new data-driven coherency method, showed significantly better coherence coefficients than other intensity normalization regions, and especially better than the most widely used global mean normalization. Intensity normalization by paracentral lobule was the most consistent method within both analysis strategies (subject-based and age-cohort averaging). In addition, the proposed new intensity normalization method using the paracentral lobule generates significantly higher differentiation from the age-associated changes than other intensity normalization methods. Conclusion Proper intensity normalization can enhance the longitudinal coherency of normal brain glucose metabolism. The paracentral lobule followed by the cerebellar tonsil are shown to be the two most stable intensity normalization regions concerning age-dependent brain metabolism. This may provide the potential to better differentiate disease-related changes from age-related changes in brain metabolism, which is of relevance in the diagnosis of neurodegenerative disorders.