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Pierre Jolicoeur

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

4 papers

1 author row

YNICL Journal 2019 Journal Article

Mild traumatic brain injury: The effect of age at trauma onset on brain structure integrity

Sébastien Tremblay
Martine Desjardins
Patrick Bermudez
Yasser Iturria-Medina
Alan C. Evans
Pierre Jolicoeur
Louis De Beaumont

Mounting evidence suggests that mild traumatic brain injuries (mTBI) have long-term effects that interact with the aging process to precipitate cognitive decline. This line of research predicts that early exposure to brain trauma is particularly detrimental to long-term brain integrity. However, a second line of research into the effects of age at trauma onset predict that older brains are more vulnerable to the effects of mTBI than younger brains. We sought to determine whether patients who sustain a mTBI earlier in life fare better than patients who sustain a mTBI at an older age. We conducted a multi-cohort, case-control study, with participants randomly sampled from a population of patients with a history of mTBI. We recruited two cohorts of aging participants (N = 74, mean [SD] = 61. 16 [6. 41]) matched in age and education levels that differed in only one respect: age at mTBI onset. One cohort sustained their concussion in their early twenties (24. 60 [6. 34] y/o), the other in their early sixties (61. 05 [4. 90] y/o). Each mTBI cohort had its own matched control group. Participants underwent high-resolution MRI at 3 Tesla for T1 and diffusion-weighted images (DWI) acquisition. Images were processed and analyzed using Deformation-Based Morphometry and DWI Tract-Based Spatial Statistics to identify group differences in a 2 × 2 ANOVA design. Results showed a significant interaction on DWI measures of white matter integrity indicating larger anomalies in participants who sustained a mTBI at a younger age (F 1, 70, P <. 05, FDR corrected). These findings suggest that mTBI initiates a lifelong neurodegeneration process that outweighs the risks associated with sustaining a mTBI at an older age. Implications are important for young athletes' populations exposed to the risk of mTBI in the practice of their sports and for retired athletes aging with a history of concussions sustained at a younger age.

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YNIMG Journal 2016 Journal Article

OMEGA: The Open MEG Archive

Guiomar Niso
Christine Rogers
Jeremy T. Moreau
Li-Yuan Chen
Cecile Madjar
Samir Das
Elizabeth Bock
François Tadel

In contrast with other imaging modalities, there is presently a scarcity of fully open resources in magnetoencephalography (MEG) available to the neuroimaging community. Here we present a collaborative effort led by the McConnell Brain Imaging Centre of the Montreal Neurological Institute, and the Université de Montréal to build and share a centralised repository to curate MEG data in raw and processed form for open dissemination. The Open MEG Archive (OMEGA, omega. bic. mni. mcgill. ca) is bound to become a continuously expanding repository of multimodal data with a primary focus on MEG, in addition to storing anatomical MRI volumes, demographic participant data and questionnaires, and other forms of electrophysiological data such as EEG. The OMEGA initiative offers both the technological framework for multi-site MEG data aggregation, and serves as one of the largest freely available resting-state and eventually task-related MEG datasets presently available.

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YNIMG Journal 2014 Journal Article

Brain activity is related to individual differences in the number of items stored in auditory short-term memory for pitch: Evidence from magnetoencephalography

Stephan Grimault
Sophie Nolden
Christine Lefebvre
François Vachon
Krista Hyde
Isabelle Peretz
Robert Zatorre
Nicolas Robitaille

We used magnetoencephalography (MEG) to examine brain activity related to the maintenance of non-verbal pitch information in auditory short-term memory (ASTM). We focused on brain activity that increased with the number of items effectively held in memory by the participants during the retention interval of an auditory memory task. We used very simple acoustic materials (i. e. , pure tones that varied in pitch) that minimized activation from non-ASTM related systems. MEG revealed neural activity in frontal, temporal, and parietal cortices that increased with a greater number of items effectively held in memory by the participants during the maintenance of pitch representations in ASTM. The present results reinforce the functional role of frontal and temporal cortices in the retention of pitch information in ASTM. This is the first MEG study to provide both fine spatial localization and temporal resolution on the neural mechanisms of non-verbal ASTM for pitch in relation to individual differences in the capacity of ASTM. This research contributes to a comprehensive understanding of the mechanisms mediating the representation and maintenance of basic non-verbal auditory features in the human brain.

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YNIMG Journal 2013 Journal Article

The retention of simultaneous tones in auditory short-term memory: A magnetoencephalography study

Sophie Nolden
Stephan Grimault
Synthia Guimond
Christine Lefebvre
Patrick Bermudez
Pierre Jolicoeur

We used magnetoencephalography (MEG) to localize brain activity related to the retention of tones differing in pitch. Participants retained one or two simultaneously presented tones. After a two second interval a test tone was presented and the task was to determine if that tone was in memory. We focused on brain activity during the retention interval that increased as the number of sounds retained in auditory short-term memory (ASTM) increased. Source analyses revealed that the superior temporal gyrus in both hemispheres is involved in ASTM. In the right hemisphere, the inferior temporal gyrus, the inferior frontal gyrus, and parietal structures also play a role. Our method provides good spatial and temporal resolution for investigating neuronal correlates of ASTM and, as it is the first MEG study using a memory load manipulation without using sequences of tones, it allowed us to isolate brain regions that most likely reflect the simple retention of tones.

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