EAAI Journal 2026 Journal Article
Neck computed tomography angiography generation from computed tomography via Mamba U-shaped convolutional network-based diffusion with content and style conditions
- Yuhang Xia
- Hongqing Zhu
- Tong Hou
- Ning Chen
- Kai Chen
- Zhong Zheng
- Bingcang Huang
Computed tomography angiography (CTA) is a widely used imaging technique for diagnosing vascular diseases, particularly in detecting conditions such as aortic aneurysms and dissections. However, traditional CTA relies on iodinated contrast agents (ICAs), which pose risks to patients and present clinical challenges such as prolonged procedure times, high costs, and increased adverse reaction risks due to repeated use. To address these issues, this paper proposes a novel deep learning-based approach for generating CTA-like images from computed tomography (CT) scans, reducing dependence on ICAs and overcoming the limitations of conventional medical procedures. Specifically, we employ a conditional denoising diffusion probabilistic model and the Mamba U-shaped convolutional network as the artificial intelligence (AI) methods for implementation. To enhance image quality and precision, we introduce content and style conditioning modules to ensure anatomical and stylistic consistency with real CTA images. Content extractors capture key anatomical features from both CT and CTA images, and frequency-domain processing further enhances vascular structures. The style extractor ensures consistency in appearance with real CTA images. Experimental results demonstrate the superior performance of the proposed AI approach. On clinical private datasets of the neck and abdomen, the structural similarity index measure (SSIM) reached scores of 0. 948 and 0. 906, respectively, indicating the successful generation of high-quality images across multiple anatomical regions. This work represents a significant advancement toward non-invasive, safer, and higher-quality CTA image generation.