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Mohammed Ghazal

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8 papers
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8

JBHI Journal 2025 Journal Article

A Vision Language Correlation Framework for Screening Disabled Retina

  • Taimur Hassan
  • Hina Raja
  • Kais Belwafi
  • Samet Akcay
  • Mohamed Jleli
  • Bessem Samet
  • Naoufel Werghi
  • Jawad Yousaf

Retinopathy is a group of retinal disabilities that causes severe visual impairments or complete blindness. Due to the capability of optical coherence tomography to reveal early retinal abnormalities, many researchers have utilized it to develop autonomous retinal screening systems. However, to the best of our knowledge, most of these systems rely only on mathematical features, which might not be helpful to clinicians since they do not encompass the clinical manifestations of screening the underlying diseases. Such clinical manifestations are critically important to be considered within the autonomous screening systems to match the grading of ophthalmologists within the clinical settings. To overcome these limitations, we present a novel framework that exploits the fusion of vision language correlation between the retinal imagery and the set of clinical prompts to recognize the different types of retinal disabilities. The proposed framework is rigorously tested on six public datasets, where, across each dataset, the proposed framework outperformed state-of-the-art methods in various metrics. Moreover, the clinical significance of the proposed framework is also tested under strict blind testing experiments, where the proposed system achieved a statistically significant correlation coefficient of 0. 9185 and 0. 9529 with the two expert clinicians. These blind test experiments highlight the potential of the proposed framework to be deployed in the real world for accurate screening of retinal diseases.

JBHI Journal 2024 Journal Article

A Clinically Explainable AI-Based Grading System for Age-Related Macular Degeneration Using Optical Coherence Tomography

  • Mohamed Elsharkawy
  • Ahmed Sharafeldeen
  • Fahmi Khalifa
  • Ahmed Soliman
  • Ahmed Elnakib
  • Mohammed Ghazal
  • Ashraf Sewelam
  • Aristomenis Thanos

We propose an automated, explainable artificial intelligence (xAI) system for age-related macular degeneration (AMD) diagnosis. Mimicking the physician's perceptions, the proposed xAI system is capable of deriving clinically meaningful features from optical coherence tomography (OCT) B-scan images to differentiate between a normal retina, different grades of AMD (early, intermediate, geographic atrophy (GA), inactive wet or active neovascular disease [exudative or wet AMD]), and non-AMD diseases. Particularly, we extract retinal OCT-based clinical imaging markers that are correlated with the progression of AMD, which include: (i) subretinal tissue, sub-retinal pigment epithelial tissue, intraretinal fluid, subretinal fluid, and choroidal hypertransmission detection using a DeepLabV3+ network; (ii) detection of merged retina layers using a novel convolutional neural network model; (iii) drusen detection based on 2D curvature analysis; (iv) estimation of retinal layers' thickness, and first-order and higher-order reflectivity features. Those clinical features are used to grade a retinal OCT in a hierarchical decision tree process. The first step looks for severe disruption of retinal layers' indicative of advanced AMD. These cases are analyzed further to diagnose GA, inactive wet AMD, active wet AMD, and non-AMD diseases. Less severe cases are analyzed using a different pipeline to identify OCT with AMD-specific pathology, which is graded as intermediate-stage or early-stage AMD. The remainder is classified as either being a normal retina or having other non-AMD pathology. The proposed system in the multi-way classification task, evaluated on 1285 OCT images, achieved 90. 82% accuracy. These promising results demonstrated the capability to automatically distinguish between normal eyes and all AMD grades in addition to non-AMD diseases.