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Minghua Deng

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10 papers

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AAAI Conference 2025 Conference Paper

Gradient-Based Sample Selection for Black-Box Universal Domain Adaptation

Qiuyan He
Minghua Deng

Universal domain adaptation (UniDA) transfers knowledge from a labelled source domain to an unlabelled target domain under domain-shift and category-shift for annotation. In reality, due to privacy protection or other limits, not only source data but also pre-trained models on it may be unavailable when training on target data. In this paper, we go a step further to explore the black-box universal domain adaptation (B^2-UniDA) problem. It requires tackling the labelling task under shifts by only accessing the interface of pre-trained source models. To this end, we introduce GSS which proposes a novel sample selection criterion based on gradient descent and Bayes' Theorem to identify samples of potential unknown classes. This criterion doesn't require manually-set thresholds depending on data used and is suitable for various datasets. GSS builds an open-set classifier and enables it to estimate probabilities of belonging to each class including the unknown category and adjust estimates adaptively. To overcome class-imbalance, especially imbalance between the unknown and known classes, we propose a balancing mechanism by measuring training status and estimating DA type. In addition to distilling knowledge from source model outputs, we focus on mining the categorical structure of target domain by self-training. Experiments on benchmarks show the state-of-the-art performance of GSS compared to typical methods, including source models or source data dependent methods.

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IJCAI Conference 2024 Conference Paper

Distribution-Independent Cell Type Identification for Single-Cell RNA-seq Data

Yuyao Zhai
Liang Chen
Minghua Deng

Automatic cell type annotation aims to transfer the label knowledge from label-abundant reference data to label-scarce target data, which makes encouraging progress in single-cell RNA-seq data analysis. While previous works have focused on classifying close-set cells and detecting open-set cells during testing, it is still essential to be able to classify unknown cell types as human beings. Additionally, few efforts have been devoted to addressing the challenge of common long-tail dilemma in cell type annotation data. Therefore, in this paper, we propose an innovative distribution-independent universal cell type identification framework called scDET from the perspective of autonomously equilibrated dual-consultative contrastive learning. Our model can generate fine-grained predictions for both close-set and open-set cell types in a long-tailed open-world environment. scDET consists of a contrastive-learning branch and a pseudo-labeling branch, which work collaboratively to provide interactive supervision. Specifically, the contrastive-learning branch provides reliable distribution estimation to regularize the predictions of the pseudo-labeling branch, which in turn guides itself through self-balanced knowledge transfer and a designed novel soft contrastive loss. Extensive experimental results on various evaluation datasets demonstrate the superior performance of scDET over other state-of-the-art single-cell clustering and annotation methods.

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AAAI Conference 2023 Conference Paper

Generalized Cell Type Annotation and Discovery for Single-Cell RNA-Seq Data

Yuyao Zhai
Liang Chen
Minghua Deng

The rapid development of single-cell RNA sequencing (scRNA-seq) technology allows us to study gene expression heterogeneity at the cellular level. Cell annotation is the basis for subsequent downstream analysis in single-cell data mining. Existing methods rarely explore the fine-grained semantic knowledge of novel cell types absent from the reference data and usually susceptible to batch effects on the classification of seen cell types. Taking into consideration these limitations, this paper proposes a new and practical task called generalized cell type annotation and discovery for scRNA-seq data. In this task, cells of seen cell types are given class labels, while cells of novel cell types are given cluster labels instead of a unified “unassigned” label. To address this problem, we carefully design a comprehensive evaluation benchmark and propose a novel end-to-end algorithm framework called scGAD. Specifically, scGAD first builds the intrinsic correspondence across the reference and target data by retrieving the geometrically and semantically mutual nearest neighbors as anchor pairs. Then we introduce an anchor-based self-supervised learning module with a connectivity-aware attention mechanism to facilitate model prediction capability on unlabeled target data. To enhance the inter-type separation and intra-type compactness, we further propose a confidential prototypical self-supervised learning module to uncover the consensus category structure of the reference and target data. Extensive results on massive real datasets demonstrate the superiority of scGAD over various state-of-the-art clustering and annotation methods.

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IJCAI Conference 2023 Conference Paper

Realistic Cell Type Annotation and Discovery for Single-cell RNA-seq Data

Yuyao Zhai
Liang Chen
Minghua Deng

The rapid development of single-cell RNA sequencing (scRNA-seq) technologies allows us to explore tissue heterogeneity at the cellular level. Cell type annotation plays an essential role in the substantial downstream analysis of scRNA-seq data. Existing methods usually classify the novel cell types in target data as an “unassigned” group and rarely discover the fine-grained cell type structure among them. Besides, these methods carry risks, such as susceptibility to batch effect between reference and target data, thus further compromising of inherent discrimination of target data. Considering these limitations, here we propose a new and practical task called realistic cell type annotation and discovery for scRNA-seq data. In this task, cells from seen cell types are given class labels, while cells from novel cell types are given cluster labels. To tackle this problem, we propose an end-to-end algorithm framework called scPOT from the perspective of optimal transport (OT). Specifically, we first design an OT-based prototypical representation learning paradigm to encourage both global discriminations of clusters and local consistency of cells to uncover the intrinsic structure of target data. Then we propose an unbalanced OT-based partial alignment strategy with statistical filling to detect the cells from the seen cell types across reference and target data. Notably, scPOT also introduces an easy yet effective solution to automatically estimate the overall cell type number in target data. Extensive results on our carefully designed evaluation benchmarks demonstrate the superiority of scPOT over various state-of-the-art clustering and annotation methods.

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AAAI Conference 2022 Conference Paper

Evidential Neighborhood Contrastive Learning for Universal Domain Adaptation

Liang Chen
Yihang Lou
Jianzhong He
Tao Bai
Minghua Deng

Universal domain adaptation (UniDA) aims to transfer the knowledge learned from a labeled source domain to an unlabeled target domain without any constraints on the label sets. However, domain shift and category shift make UniDA extremely challenging, mainly attributed to the requirement of identifying both shared “known” samples and private “unknown” samples. Previous methods barely exploit the intrinsic manifold structure relationship between two domains for feature alignment, and they rely on the softmax-based scores with class competition nature to detect underlying “unknown” samples. Therefore, in this paper, we propose a novel evidenTial Neighborhood conTrastive learning framework called TNT to address these issues. Specifically, TNT first proposes a new domain alignment principle: semantically consistent samples should be geometrically adjacent to each other, whether within or across domains. From this criterion, a cross domain multi-sample contrastive loss based on mutual nearest neighbors is designed to achieve common category matching and private category separation. Second, toward accurate “unknown” sample detection, TNT introduces a class competition-free uncertainty score from the perspective of evidential deep learning. Instead of setting a single threshold, TNT learns a category-aware heterogeneous threshold vector to reject diverse “unknown” samples. Extensive experiments on three benchmarks demonstrate that TNT significantly outperforms previous state-of-the-art UniDA methods.

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IJCAI Conference 2022 Conference Paper

Improved Deep Unsupervised Hashing with Fine-grained Semantic Similarity Mining for Multi-Label Image Retrieval

Zeyu Ma
Xiao Luo
Yingjie Chen
Mixiao Hou
Jinxing Li
Minghua Deng
Guangming Lu

In this paper, we study deep unsupervised hashing, a critical problem for approximate nearest neighbor research. Most recent methods solve this problem by semantic similarity reconstruction for guiding hashing network learning or contrastive learning of hash codes. However, in multi-label scenarios, these methods usually either generate an inaccurate similarity matrix without reflection of similarity ranking or suffer from the violation of the underlying assumption in contrastive learning, resulting in limited retrieval performance. To tackle this issue, we propose a novel method termed HAMAN, which explores semantics from a fine-grained view to enhance the ability of multi-label image retrieval. In particular, we reconstruct the pairwise similarity structure by matching fine-grained patch features generated by the pre-trained neural network, serving as reliable guidance for similarity preserving of hash codes. Moreover, a novel conditional contrastive learning on hash codes is proposed to adopt self-supervised learning in multi-label scenarios. According to extensive experiments on three multi-label datasets, the proposed method outperforms a broad range of state-of-the-art methods.

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AAAI Conference 2022 Conference Paper

Mutual Nearest Neighbor Contrast and Hybrid Prototype Self-Training for Universal Domain Adaptation

Liang Chen
Qianjin Du
Yihang Lou
Jianzhong He
Tao Bai
Minghua Deng

Universal domain adaptation (UniDA) aims to transfer knowledge learned from a labeled source domain to an unlabeled target domain under domain shift and category shift. Without prior category overlap information, it is challenging to simultaneously align the common categories between two domains and separate their respective private categories. Additionally, previous studies utilize the source classifier’s prediction to obtain various known labels and one generic “unknown” label of target samples. However, overreliance on learned classifier knowledge is inevitably biased to source data, ignoring the intrinsic structure of target domain. Therefore, in this paper, we propose a novel two-stage UniDA framework called MATHS based on the principle of Mutual neArest neighbor conTrast and Hybrid prototype diScrimination. In the first stage, we design an efficient mutual nearest neighbor contrastive learning scheme to achieve feature alignment, which exploits the instance-level affinity relationship to uncover the intrinsic structure of two domains. We introduce a bimodality hypothesis for the maximum discriminative probability distribution to detect the possible target private samples, and present a data-based statistical approach to separate the common and private categories. In the second stage, to obtain more reliable label predictions, we propose an incremental pseudo-classifier for target data only, which is driven by the hybrid representative prototypes. A confidence-guided prototype contrastive loss is designed to optimize the category allocation uncertainty via a selftraining mechanism. Extensive experiments on three benchmarks demonstrate that MATHS outperforms previous stateof-the-arts on most UniDA settings.

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AAAI Conference 2022 Conference Paper

Neighborhood Consensus Contrastive Learning for Backward-Compatible Representation

Shengsen Wu
Liang Chen
Yihang Lou
Yan Bai
Tao Bai
Minghua Deng
Ling-Yu Duan

In object re-identification (ReID), the development of deep learning techniques often involves model updates and deployment. It is unbearable to re-embedding and re-index with the system suspended when deploying new models. Therefore, backward-compatible representation is proposed to enable “new” features to be compared with “old” features directly, which means that the database is active when there are both “new” and “old” features in it. Thus we can scroll-refresh the database or even do nothing on the database to update. The existing backward-compatible methods either require a strong overlap between old and new training data or simply conduct constraints at the instance level. Thus they are difficult in handling complicated cluster structures and are limited in eliminating the impact of outliers in old embeddings, resulting in a risk of damaging the discriminative capability of new features. In this work, we propose a Neighborhood Consensus Contrastive Learning (NCCL) method. With no assumptions about the new training data, we estimate the subcluster structures of old embeddings. A new embedding is constrained with multiple old embeddings in both embedding space and discrimination space at the sub-class level. The effect of outliers diminished, as the multiple samples serve as “mean teachers”. Besides, we propose a scheme to filter the old embeddings with low credibility, further improving the compatibility robustness. Our method ensures the compatibility without impairing the accuracy of the new model. It can even improve the new model’s accuracy in most scenarios.

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IJCAI Conference 2022 Conference Paper

TGNN: A Joint Semi-supervised Framework for Graph-level Classification

Wei Ju
Xiao Luo
Meng Qu
Yifan Wang
Chong Chen
Minghua Deng
Xian-Sheng Hua
Ming Zhang

This paper studies semi-supervised graph classification, a crucial task with a wide range of applications in social network analysis and bioinformatics. Recent works typically adopt graph neural networks to learn graph-level representations for classification, failing to explicitly leverage features derived from graph topology (e. g. , paths). Moreover, when labeled data is scarce, these methods are far from satisfactory due to their insufficient topology exploration of unlabeled data. We address the challenge by proposing a novel semi-supervised framework called Twin Graph Neural Network (TGNN). To explore graph structural information from complementary views, our TGNN has a message passing module and a graph kernel module. To fully utilize unlabeled data, for each module, we calculate the similarity of each unlabeled graph to other labeled graphs in the memory bank and our consistency loss encourages consistency between two similarity distributions in different embedding spaces. The two twin modules collaborate with each other by exchanging instance similarity knowledge to fully explore the structure information of both labeled and unlabeled data. We evaluate our TGNN on various public datasets and show that it achieves strong performance.

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IJCAI Conference 2021 Conference Paper

CIMON: Towards High-quality Hash Codes

Xiao Luo
Daqing Wu
Zeyu Ma
Chong Chen
Minghua Deng
Jinwen Ma
Zhongming Jin
Jianqiang Huang

Recently, hashing is widely used in approximate nearest neighbor search for its storage and computational efficiency. Most of the unsupervised hashing methods learn to map images into semantic similarity-preserving hash codes by constructing local semantic similarity structure from the pre-trained model as the guiding information, i. e. , treating each point pair similar if their distance is small in feature space. However, due to the inefficient representation ability of the pre-trained model, many false positives and negatives in local semantic similarity will be introduced and lead to error propagation during the hash code learning. Moreover, few of the methods consider the robustness of models, which will cause instability of hash codes to disturbance. In this paper, we propose a new method named Comprehensive sImilarity Mining and cOnsistency learNing (CIMON). First, we use global refinement and similarity statistical distribution to obtain reliable and smooth guidance. Second, both semantic and contrastive consistency learning are introduced to derive both disturb-invariant and discriminative hash codes. Extensive experiments on several benchmark datasets show that the proposed method outperforms a wide range of state-of-the-art methods in both retrieval performance and robustness.

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