EAAI Journal 2026 Journal Article
A deep learning-based imaging classification framework for interstitial lung disease
- Hongyi Wang
- Anqi Liu
- Xiaoyan Yang
- Yifei Ni
- Jianping Wang
- Jie Du
- Yuhui Qiang
- Bingbing Xie
Rationale Interstitial lung diseases (ILD) are a diverse group of conditions, often diagnosed using high-resolution chest computed tomography (HRCT), which is susceptible to subjective biases in interpretation. Objectives This study aims to develop and validate SPAIDNet (Spatial Pattern Analysis for ILD Diagnosis using a residual neural Network), a deep learning (DL) model for the automated classification of ILD, to reduce subjective biases and improve diagnostic consistency. Methods The study included 2901 ILD patients who underwent 5213 HRCT scans across multiple centers between July 2017 and June 2023. SPAIDNet, built upon the pre-trained residual neural network with 18 layers, utilizes multi-instance learning in three centers in China. Measurements and main results The model demonstrated exceptional performance, achieving macro-average area under the receiver operating characteristic curve (AUC) of over 0. 999 in internal validation, 0. 905 in external cohort I, and 0. 870 in external cohort II for multiclass classification. SPAIDNet outperformed both a junior radiologist (AUC: 0. 737) and a senior radiologist (AUC: 0. 763). Furthermore, DL-assisted the two radiologists saw significant improvements in diagnostic accuracy, with AUCs rising to 0. 817 and 0. 787, respectively. Conclusions These results underscore SPAIDNet's potential to offer high accuracy, robustness, and generalizability in ILD diagnosis, providing a valuable tool to mitigate the subjectivity inherent in HRCT image interpretation.