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Mengran Li

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3 papers

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AAAI Conference 2026 Conference Paper

Learning Cell-Aware Hierarchical Multi-Modal Representations for Robust Molecular Modeling

Mengran Li
Zelin Zang
Wenbin Xing
Junzhou Chen
Ronghui Zhang
Jiebo Luo
Stan Z. Li

Understanding how chemical perturbations propagate through biological systems is essential for robust molecular property prediction. While most existing methods focus on chemical structures alone, recent advances highlight the crucial role of cellular responses such as morphology and gene expression in shaping drug effects. However, current cell-aware approaches face two key limitations: (1) modality incompleteness in external biological data, and (2) insufficient modeling of hierarchical dependencies across molecular, cellular, and genomic levels. We propose CHMR (Cell-aware Hierarchical Multi-Modal Representations), a robust framework that jointly models local-global dependencies between molecules and cellular responses and captures latent biological hierarchies via a novel tree-structured vector quantization module. Evaluated on public benchmarks spanning 696 tasks, CHMR outperforms state-of-the-art baselines, yielding average improvements of 3.6% on classification and 17.2% on regression tasks. These results demonstrate the advantage of hierarchy-aware, multi-modal learning for reliable and biologically grounded molecular representations, offering a generalizable framework for integrative biomedical modeling.

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IJCAI Conference 2025 Conference Paper

ElaD-Net: An Elastic Semantic Decoupling Network for Lesion Segmentation in Breast Ultrasound Images

Lijuan Xu
Kai Wang
Fuqiang Yu
Fenghua Tong
Mengran Li
Dawei Zhao

Breast diseases pose a significant threat to women’s health. Automatic lesion segmentation in breast ultrasound images (BUSI) plays a crucial role in fast diagnosis. While various enhanced U-Net-based models have achieved success in multi-scale feature analysis and handling blurred boundaries, two key challenges persist that could guide the improvement of BUSI segmentation networks: 1) significant fluctuations in pixel intensity distribution similarity between the lesion and surrounding tissues, and 2) inconsistent transmission of spatial detail due to multi-scale lesion sampling. These issues highlight the necessity of semantic elasticity understanding and consistency control. To this end, we propose ElaD-Net, an Elastic Semantic Decoupling Network for lesion segmentation in BUSI. This network uses the pre-trained EfficientNet-B2 for multi-scale encoding of BUSI. The decoding stage features two key modules: Elastic Semantic Decoupling (ESD) and Spatial Semantic Reconstruction (SSR). ESD learns and decouples multi-frequency semantics in multi-scale channels with a self-calibration mechanism, enabling dynamic adjustment of receptive depth to resist similarity fluctuations. SSR further optimizes ESD outputs via feature branching, compression, and excitation to ensure spatial semantic consistency, thereby separately reconstructing edge and body.

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EAAI Journal 2022 Journal Article

Multi-view hypergraph neural networks for student academic performance prediction

Mengran Li
Yong Zhang
Xiaoyong Li
Lijia Cai
Baocai Yin

Academic performance prediction is a fundamental and hot issue in educational data mining (EDM). Recently, researchers have proposed a series of effective machine learning (ML) based classification strategies to predict students’ academic performance. However, prior arts are typically concerned about individual models but neglect the association among students, which might considerably have an effect on the integrity of the academic performance-related representations. Meanwhile, students’ multi-viewing behavior contains complex relations among students. Therefore, we propose a Multi-View Hypergraph Neural Network (MVHGNN) for predicting students’ academic performance. MVHGNN uses hypergraphs to construct high-order relations among students. The semantic information implied by multiple behaviors is consolidated through meta-paths. Further, a Cascade Attention Transformer (CAT) module is introduced to mine the weight of different behaviors by the self-attention mechanism. Our method is evaluated on real campus student behavioral datasets. The experimental results demonstrate that our method outperforms the state-of-the-art ones.

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