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Ling Yu

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YNICL Journal 2019 Journal Article

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease

  • Jing Du
  • Yao Wang
  • Nan Zhi
  • Jieli Geng
  • Wenwei Cao
  • Ling Yu
  • Jianhua Mi
  • Yan Zhou

OBJECTIVES: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures. METHOD: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed. SVD scores were calculated on a standard scale, and structural brain network measures were analyzed by diffusion tensor imaging (DTI). Between-group differences were analyzed, and logistic regression was applied to determine the predictive value of SVD and network measures for cognitive status. Mediation analysis with structural equation modeling (SEM) was used to better understand the interactions of SVD burden, brain networks and cognitive deficits. RESULTS: ) was significantly related to cognitive state (p < .01) but not the SVD score. Mediation analysis showed that the standardized total effect (p = .013) and the standardized indirect effect (p = .016) of SVD score on cognition was significant, but the direct effect was not. CONCLUSIONS: Brain network measures, but not the SVD score, are significantly correlated with cognition in post-stroke SVD patients. Mediation analysis showed that the cerebral vascular lesions produce cognitive dysfunction by interfering with the structural brain network in SVD patients. The brain network measures may be regarded as direct and independent surrogate markers of cognitive impairment in SVD.

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AAMAS Conference 2011 Conference Paper

Genetic Algorithm Aided Optimization of Hierarchical Multiagent System Organization

  • Ling Yu
  • Zhiqi Shen
  • Chunyan Miao
  • Victor Lesser

In this paper, we propose a genetic algorithm aided optimization scheme for designing the organization of hierarchical multiagent systems. We introduce the hierarchical genetic algorithm, in which hierarchical crossover with a repair strategy and mutation of small perturbation are used. The phenotypic hierarchical structure space is translated to the genome-like array representation space, which makes the algorithm genetic-operator-literate. Our experiments show that competitive structures can be found by the proposed algorithm. Compared with traditional operators, the new operators produced better organizations of higher utility more consistently. The proposed algorithm extends the search processes of the state-of-the-art multiagent organization design methodologies, and is more computationally efficient in a large search space.

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