EAAI Journal 2026 Journal Article
A knowledge prompt augmented lightweight multimodal language assistant for biomedicine
- Lei Liu
- Xiangdong Su
- Xingxiang Zhou
- Guanglai Gao
Hallucinations caused by uncertain reasoning are critical in multimodal large language models, where factual correctness is vital for clinical applications. This challenge is further exacerbated in resource-constrained lightweight models due to their limited capacity and lack of domain-specific knowledge. To address this, we propose a knowledge prompt-augmented, lightweight multimodal language assistant for biomedicine (BioMiLA-K). BioMiLA-K incorporates relevant entities from a pre-built knowledge base as prompts, mitigating hallucinations and improving reasoning. We introduce a Knowledge Match Mechanism module for multimodal entity selection: a biomedical vision-language pretraining model encodes medical images, retrieves similar embeddings from the knowledge base, and links them to corresponding textual entities. A multilayer perceptron model, trained with cross-entropy and ranking losses, selects the most relevant entities for the prompt. Next, we propose an Entity Attention Optimization module, which enables the language model to dynamically assess entity importance by computing cross-attention among entities, images, and questions. A self-supervised attention loss guides BioMiLA-K to focus on critical knowledge and generate accurate responses. Using 80, 080 medical image-text pairs, we build a multimodal knowledge base and generate 90, 000 visual instruction samples. BioMiLA-K adopts a two-stage instruction tuning: image-caption alignment tuning, followed by low-rank adaptation fine-tuning on the generated data. With just 0. 79 billion parameters, it achieves competitive performance on multiple medical visual question answering benchmarks. Its sub-billion scale enables training and deployment on a single graphics processing unit with 24 GB of memory, demonstrating that explicit knowledge grounding can effectively substitute for large model size in biomedical artificial intelligence-based multimodal language systems.