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Laura E. Jonkman

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

3 papers

1 author row

YNIMG Journal 2020 Journal Article

Evaluation of the diffusion MRI white matter tract integrity model using myelin histology and Monte-Carlo simulations

Zihan Zhou
Qiqi Tong
Lei Zhang
Qiuping Ding
Hui Lu
Laura E. Jonkman
Junye Yao
Hongjian He

Quantitative evaluation of brain myelination has drawn considerable attention. Conventional diffusion-based magnetic resonance imaging models, including diffusion tensor imaging and diffusion kurtosis imaging (DKI), 1 1 AD: Axial diffusivity; AK: Axial kurtosis; AVF: Axonal volume fraction; AWF: Axonal Water Fraction; DTI: Diffusion Tensor Imaging; DKI: Diffusion Kurtosis Imaging; dMRI: Diffusion magnetic resonance imaging; TE: Echo time; FOV: Field-of-view; FA: Fractional anisotropy; LFB: Luxor fast blue; MD: Mean diffusivity; MK: Mean kurtosis; MRI: Magnetic resonance imaging; MVF: Myelin volume fraction; PLP: Proteolipid protein; RESOLVE: Readout segmentation of long variable echo train; RD: Radial diffusivity; RK: Radial kurtosis; TR: Repetition time; ROI: Region-of-interest; WM: White matter; WMTI: White Matter Tract Integrity. have been used to infer the microstructure and its changes in neurological diseases. White matter tract integrity (WMTI) was proposed as a biophysical model to relate the DKI-derived metrics to the underlying microstructure. Although the model has been validated on ex vivo animal brains, it was not well evaluated with ex vivo human brains. In this study, histological samples (namely corpus callosum) from postmortem human brains have been investigated based on WMTI analyses on a clinical 3T scanner and comparisons with gold standard myelin staining in proteolipid protein and Luxol fast blue. In addition, Monte Carlo simulations were conducted to link changes from ex vivo to in vivo conditions based on the microscale parameters of water diffusivity and permeability. The results show that WMTI metrics, including axonal water fraction AWF, radial extra-axonal diffusivity D e ⊥, and intra-axonal diffusivity Da were needed to characterize myelin content alterations. Thus, WMTI model metrics are shown to be promising candidates as sensitive biomarkers of demyelination.

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YNICL Journal 2019 Journal Article

7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease

Boyd Kenkhuis
Laura E. Jonkman
Marjolein Bulk
Mathijs Buijs
Baayla D.C. Boon
Femke H. Bouwman
Jeroen J.G. Geurts
Wilma D.J. van de Berg

Using 7T T2⁎-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the cases, appearance of cortical lamination varied to a greater extent in the Alzheimer patients. Severely distorted cortical lamination was also observed in advanced stage Alzheimer patients and presented itself as a broad hypointense inhomogeneous band, covering a large part of the cortical width. Histology indicated that the changes in the appearance of visible cortical lamination were not only associated with myelin changes, but also with diffuse cortical iron alterations and depositions. Therefore, imaging cortical lamination alterations in Alzheimer patients using T2*-weighted MRI might provide new information on involved neuroanatomical structures in an advanced neurodegenerative stage.

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YNICL Journal 2019 Journal Article

Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls

Laura E. Jonkman
Yvon Galis-de Graaf
Marjolein Bulk
Eliane Kaaij
Petra J.W. Pouwels
Frederik Barkhof
Annemieke J.M. Rozemuller
Louise van der Weerd

Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

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