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Lars Kai Hansen

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35 papers
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35

TMLR Journal 2026 Journal Article

BiSSL: Enhancing the Alignment Between Self-Supervised Pretraining and Downstream Fine-Tuning via Bilevel Optimization

  • Gustav Wagner Zakarias
  • Lars Kai Hansen
  • Zheng-Hua Tan

Models initialized from self-supervised pretraining may suffer from poor alignment with downstream tasks, limiting the extent to which subsequent fine-tuning can adapt relevant representations acquired during the pretraining phase. To mitigate this, we introduce BiSSL, a novel bilevel training framework that enhances the alignment of self-supervised pretrained models with downstream tasks by explicitly incorporating both the pretext and downstream tasks into a preparatory training stage prior to fine-tuning. BiSSL solves a bilevel optimization problem in which the lower-level adheres to the self-supervised pretext task, while the upper-level encourages the lower-level backbone to align with the downstream objective. The bilevel structure facilitates enhanced information sharing between the tasks, ultimately yielding a backbone model that is more aligned with the downstream task, providing a better initialization for subsequent fine-tuning. We propose a general training algorithm for BiSSL that is compatible with a broad range of pretext and downstream tasks. We demonstrate that our proposed framework significantly improves accuracy on the vast majority of a broad selection of image-domain downstream tasks, and that these gains are consistently retained across a wide range of experimental settings. In addition, exploratory alignment analyses further underpin that BiSSL enhances downstream alignment of pretrained representations.

NeurIPS Conference 2025 Conference Paper

Minimizing False-Positive Attributions in Explanations of Non-Linear Models

  • Anders Gjølbye
  • Stefan Haufe
  • Lars Kai Hansen

Suppressor variables can influence model predictions without being dependent on the target outcome, and they pose a significant challenge for Explainable AI (XAI) methods. These variables may cause false-positive feature attributions, undermining the utility of explanations. Although effective remedies exist for linear models, their extension to non-linear models and instance-based explanations has remained limited. We introduce PatternLocal, a novel XAI technique that addresses this gap. PatternLocal begins with a locally linear surrogate, e. g. , LIME, KernelSHAP, or gradient-based methods, and transforms the resulting discriminative model weights into a generative representation, thereby suppressing the influence of suppressor variables while preserving local fidelity. In extensive hyperparameter optimization on the XAI-TRIS benchmark, PatternLocal consistently outperformed other XAI methods and reduced false-positive attributions when explaining non-linear tasks, thereby enabling more reliable and actionable insights. We further evaluate PatternLocal on an EEG motor imagery dataset, demonstrating physiologically plausible explanations.

ICLR Conference 2024 Conference Paper

Masked Autoencoders with Multi-Window Local-Global Attention Are Better Audio Learners

  • Sarthak Yadav
  • Sergios Theodoridis
  • Lars Kai Hansen
  • Zheng-Hua Tan

In this work, we propose a Multi-Window Masked Autoencoder (MW-MAE) fitted with a novel Multi-Window Multi-Head Attention (MW-MHA) module that facilitates the modelling of local-global interactions in every decoder transformer block through attention heads of several distinct local and global windows. Empirical results on ten downstream audio tasks show that MW-MAEs consistently outperform standard MAEs in overall performance and learn better general-purpose audio representations, along with demonstrating considerably better scaling characteristics. Investigating attention distances and entropies reveals that MW-MAE encoders learn heads with broader local and global attention. Analyzing attention head feature representations through Projection Weighted Canonical Correlation Analysis (PWCCA) shows that attention heads with the same window sizes across the decoder layers of the MW-MAE learn correlated feature representations which enables each block to independently capture local and global information, leading to a decoupled decoder feature hierarchy.

UAI Conference 2023 Conference Paper

On the role of model uncertainties in Bayesian optimisation

  • Jonathan Foldager
  • Mikkel Jordahn
  • Lars Kai Hansen
  • Michael Riis Andersen

Bayesian Optimization (BO) is a popular method for black-box optimization, which relies on uncertainty as part of its decision-making process when deciding which experiment to perform next. However, not much work has addressed the effect of uncertainty on the performance of the BO algorithm and to what extent calibrated uncertainties improve the ability to find the global optimum. In this work, we provide an extensive study of the relationship between the BO performance (regret) and uncertainty calibration for popular surrogate models and acquisition functions, and compare them across both synthetic and real-world experiments. Our results show that Gaussian Processes, and more surprisingly, Deep Ensembles are strong surrogate models. Our results further show a positive association between calibration error and regret, but interestingly, this association disappears when we control for the type of surrogate model in the analysis. We also study the effect of recalibration and demonstrate that it generally does not lead to improved regret. Finally, we provide theoretical justification for why uncertainty calibration might be difficult to combine with BO due to the small sample sizes commonly used.

ICML Conference 2019 Conference Paper

Phase transition in PCA with missing data: Reduced signal-to-noise ratio, not sample size!

  • Niels Bruun Ipsen
  • Lars Kai Hansen

How does missing data affect our ability to learn signal structures? It has been shown that learning signal structure in terms of principal components is dependent on the ratio of sample size and dimensionality and that a critical number of observations is needed before learning starts (Biehl and Mietzner, 1993). Here we generalize this analysis to include missing data. Probabilistic principal component analysis is regularly used for estimating signal structures in datasets with missing data. Our analytic result suggest that the effect of missing data is to effectively reduce signal-to-noise ratio rather than - as generally believed - to reduce sample size. The theory predicts a phase transition in the learning curves and this is indeed found both in simulation data and in real datasets.

JMLR Journal 2017 Journal Article

Bayesian Inference for Spatio-temporal Spike-and-Slab Priors

  • Michael Riis Andersen
  • Aki Vehtari
  • Ole Winther
  • Lars Kai Hansen

In this work, we address the problem of solving a series of underdetermined linear inverse problemblems subject to a sparsity constraint. We generalize the spike-and-slab prior distribution to encode a priori correlation of the support of the solution in both space and time by imposing a transformed Gaussian process on the spike-and-slab probabilities. An expectation propagation (EP) algorithm for posterior inference under the proposed model is derived. For large scale problems, the standard EP algorithm can be prohibitively slow. We therefore introduce three different approximation schemes to reduce the computational complexity. Finally, we demonstrate the proposed model using numerical experiments based on both synthetic and real data sets. [abs] [ pdf ][ bib ] &copy JMLR 2017. ( edit, beta )

YNIMG Journal 2017 Journal Article

Spatio-temporal reconstruction of brain dynamics from EEG with a Markov prior

  • Sofie Therese Hansen
  • Lars Kai Hansen

Electroencephalography (EEG) can capture brain dynamics in high temporal resolution. By projecting the scalp EEG signal back to its origin in the brain also high spatial resolution can be achieved. Source localized EEG therefore has potential to be a very powerful tool for understanding the functional dynamics of the brain. Solving the inverse problem of EEG is however highly ill-posed as there are many more potential locations of the EEG generators than EEG measurement points. Several well-known properties of brain dynamics can be exploited to alleviate this problem. More short ranging connections exist in the brain than long ranging, arguing for spatially focal sources. Additionally, recent work (Delorme et al. , 2012) argues that EEG can be decomposed into components having sparse source distributions. On the temporal side both short and long term stationarity of brain activation are seen. We summarize these insights in an inverse solver, the so-called “Variational Garrote” (Kappen and Gómez, 2013). Using a Markov prior we can incorporate flexible degrees of temporal stationarity. Through spatial basis functions spatially smooth distributions are obtained. Sparsity of these are inherent to the Variational Garrote solver. We name our method the MarkoVG and demonstrate its ability to adapt to the temporal smoothness and spatial sparsity in simulated EEG data. Finally a benchmark EEG dataset is used to demonstrate MarkoVG's ability to recover non-stationary brain dynamics.

YNIMG Journal 2016 Journal Article

Data-driven forward model inference for EEG brain imaging

  • Sofie Therese Hansen
  • Søren Hauberg
  • Lars Kai Hansen

Electroencephalography (EEG) is a flexible and accessible tool with excellent temporal resolution but with a spatial resolution hampered by volume conduction. Reconstruction of the cortical sources of measured EEG activity partly alleviates this problem and effectively turns EEG into a brain imaging device. The quality of the source reconstruction depends on the forward model which details head geometry and conductivities of different head compartments. These person-specific factors are complex to determine, requiring detailed knowledge of the subject's anatomy and physiology. In this proof-of-concept study, we show that, even when anatomical knowledge is unavailable, a suitable forward model can be estimated directly from the EEG. We propose a data-driven approach that provides a low-dimensional parametrization of head geometry and compartment conductivities, built using a corpus of forward models. Combined with only a recorded EEG signal, we are able to estimate both the brain sources and a person-specific forward model by optimizing this parametrization. We thus not only solve an inverse problem, but also optimize over its specification. Our work demonstrates that personalized EEG brain imaging is possible, even when the head geometry and conductivities are unknown.

YNIMG Journal 2016 Journal Article

The Center for Integrated Molecular Brain Imaging (Cimbi) database

  • Gitte M. Knudsen
  • Peter S. Jensen
  • David Erritzoe
  • William F.C. Baaré
  • Anders Ettrup
  • Patrick M. Fisher
  • Nic Gillings
  • Hanne D. Hansen

We here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes. The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies. The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e. g. , major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank.

YNIMG Journal 2014 Journal Article

Frontal alpha oscillations distinguish leaders from followers: Multivariate decoding of mutually interacting brains

  • Ivana Konvalinka
  • Markus Bauer
  • Carsten Stahlhut
  • Lars Kai Hansen
  • Andreas Roepstorff
  • Chris D. Frith

Successful social interactions rely upon the abilities of two or more people to mutually exchange information in real-time, while simultaneously adapting to one another. The neural basis of social cognition has mostly been investigated in isolated individuals, and more recently using two-person paradigms to quantify the neuronal dynamics underlying social interaction. While several studies have shown the relevance of understanding complementary and mutually adaptive processes, the neural mechanisms underlying such coordinative behavioral patterns during joint action remain largely unknown. Here, we employed a synchronized finger-tapping task while measuring dual-EEG from pairs of human participants who either mutually adjusted to each other in an interactive task or followed a computer metronome. Neurophysiologically, the interactive condition was characterized by a stronger suppression of alpha and low-beta oscillations over motor and frontal areas in contrast to the non-interactive computer condition. A multivariate analysis of two-brain activity to classify interactive versus non-interactive trials revealed asymmetric patterns of the frontal alpha-suppression in each pair, during both task anticipation and execution, such that only one member showed the frontal component. Analysis of the behavioral data showed that this distinction coincided with the leader–follower relationship in 8/9 pairs, with the leaders characterized by the stronger frontal alpha-suppression. This suggests that leaders invest more resources in prospective planning and control. Hence our results show that the spontaneous emergence of leader–follower relationships in dyadic interactions can be predicted from EEG recordings of brain activity prior to and during interaction. Furthermore, this emphasizes the importance of investigating complementarity in joint action.

YNIMG Journal 2014 Journal Article

Non-parametric Bayesian graph models reveal community structure in resting state fMRI

  • Kasper Winther Andersen
  • Kristoffer H. Madsen
  • Hartwig Roman Siebner
  • Mikkel N. Schmidt
  • Morten Mørup
  • Lars Kai Hansen

Modeling of resting state functional magnetic resonance imaging (rs-fMRI) data using network models is of increasing interest. It is often desirable to group nodes into clusters to interpret the communication patterns between nodes. In this study we consider three different nonparametric Bayesian models for node clustering in complex networks. In particular, we test their ability to predict unseen data and their ability to reproduce clustering across datasets. The three generative models considered are the Infinite Relational Model (IRM), Bayesian Community Detection (BCD), and the Infinite Diagonal Model (IDM). The models define probabilities of generating links within and between clusters and the difference between the models lies in the restrictions they impose upon the between-cluster link probabilities. IRM is the most flexible model with no restrictions on the probabilities of links between clusters. BCD restricts the between-cluster link probabilities to be strictly lower than within-cluster link probabilities to conform to the community structure typically seen in social networks. IDM only models a single between-cluster link probability, which can be interpreted as a background noise probability. These probabilistic models are compared against three other approaches for node clustering, namely Infomap, Louvain modularity, and hierarchical clustering. Using 3 different datasets comprising healthy volunteers' rs-fMRI we found that the BCD model was in general the most predictive and reproducible model. This suggests that rs-fMRI data exhibits community structure and furthermore points to the significance of modeling heterogeneous between-cluster link probabilities.

YNIMG Journal 2012 Journal Article

Nonlinear denoising and analysis of neuroimages with kernel principal component analysis and pre-image estimation

  • Peter Mondrup Rasmussen
  • Trine Julie Abrahamsen
  • Kristoffer Hougaard Madsen
  • Lars Kai Hansen

We investigate the use of kernel principal component analysis (PCA) and the inverse problem known as pre-image estimation in neuroimaging: i) We explore kernel PCA and pre-image estimation as a means for image denoising as part of the image preprocessing pipeline. Evaluation of the denoising procedure is performed within a data-driven split-half evaluation framework. ii) We introduce manifold navigation for exploration of a nonlinear data manifold, and illustrate how pre-image estimation can be used to generate brain maps in the continuum between experimentally defined brain states/classes. We base these illustrations on two fMRI BOLD data sets — one from a simple finger tapping experiment and the other from an experiment on object recognition in the ventral temporal lobe.

JMLR Journal 2011 Journal Article

A Cure for Variance Inflation in High Dimensional Kernel Principal Component Analysis

  • Trine Julie Abrahamsen
  • Lars Kai Hansen

Small sample high-dimensional principal component analysis (PCA) suffers from variance inflation and lack of generalizability. It has earlier been pointed out that a simple leave-one-out variance renormalization scheme can cure the problem. In this paper we generalize the cure in two directions: First, we propose a computationally less intensive approximate leave-one-out estimator, secondly, we show that variance inflation is also present in kernel principal component analysis (kPCA) and we provide a non-parametric renormalization scheme which can quite efficiently restore generalizability in kPCA. As for PCA our analysis also suggests a simplified approximate expression. [abs] [ pdf ][ bib ] &copy JMLR 2011. ( edit, beta )

YNIMG Journal 2011 Journal Article

Visualization of nonlinear kernel models in neuroimaging by sensitivity maps

  • Peter Mondrup Rasmussen
  • Kristoffer Hougaard Madsen
  • Torben Ellegaard Lund
  • Lars Kai Hansen

There is significant current interest in decoding mental states from neuroimages. In this context kernel methods, e. g. , support vector machines (SVM) are frequently adopted to learn statistical relations between patterns of brain activation and experimental conditions. In this paper we focus on visualization of such nonlinear kernel models. Specifically, we investigate the sensitivity map as a technique for generation of global summary maps of kernel classification models. We illustrate the performance of the sensitivity map on functional magnetic resonance (fMRI) data based on visual stimuli. We show that the performance of linear models is reduced for certain scan labelings/categorizations in this data set, while the nonlinear models provide more flexibility. We show that the sensitivity map can be used to visualize nonlinear versions of kernel logistic regression, the kernel Fisher discriminant, and the SVM, and conclude that the sensitivity map is a versatile and computationally efficient tool for visualization of nonlinear kernel models in neuroimaging.

YNIMG Journal 2008 Journal Article

Segmentation of age-related white matter changes in a clinical multi-center study

  • Tim B. Dyrby
  • Egill Rostrup
  • William F.C. Baaré
  • Elisabeth C.W. van Straaten
  • Frederik Barkhof
  • Hugo Vrenken
  • Stefan Ropele
  • Reinhold Schmidt

Age-related white matter changes (WMC) are thought to be a marker of vascular pathology, and have been associated with motor and cognitive deficits. In the present study, an optimized artificial neural network was used as an automatic segmentation method to produce probabilistic maps of WMC in a clinical multi-center study. The neural network uses information from T1- and T2-weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) scans, neighboring voxels and spatial location. Generalizability of the neural network was optimized by including the Optimal Brain Damage (OBD) pruning method in the training stage. Six optimized neural networks were produced to investigate the impact of different input information on WMC segmentation. The automatic segmentation method was applied to MR scans of 362 non-demented elderly subjects from 11 centers in the European multi-center study Leukoaraiosis And Disability (LADIS). Semi-manually delineated WMC were used for validating the segmentation produced by the neural networks. The neural network segmentation demonstrated high consistency between subjects and centers, making it a promising technique for large studies. For WMC volumes less than 10 ml, an increasing discrepancy between semi-manual and neural network segmentation was observed using the similarity index (SI) measure. The use of all three image modalities significantly improved cross-center generalizability compared to neural networks using the FLAIR image only. Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error.

YNIMG Journal 2008 Journal Article

Shift-invariant multilinear decomposition of neuroimaging data

  • Morten Mørup
  • Lars Kai Hansen
  • Sidse Marie Arnfred
  • Lek-Heng Lim
  • Kristoffer Hougaard Madsen

We present an algorithm for multilinear decomposition that allows for arbitrary shifts along one modality. The method is applied to neural activity arranged in the three modalities space, time, and trial. Thus, the algorithm models neural activity as a linear superposition of components with a fixed time course that may vary across either trials or space in its overall intensity and latency. Its utility is demonstrated on simulated data as well as actual EEG, and fMRI data. We show how shift-invariant multilinear decompositions of multiway data can successfully cope with variable latencies in data derived from neural activity — a problem that has caused degenerate solutions especially in modeling neuroimaging data with instantaneous multilinear decompositions. Our algorithm is available for download at www. erpwavelab. org.

JMLR Journal 2006 Journal Article

Linear State-Space Models for Blind Source Separation

  • Rasmus Kongsgaard Olsson
  • Lars Kai Hansen

We apply a type of generative modelling to the problem of blind source separation in which prior knowledge about the latent source signals, such as time-varying auto-correlation and quasi-periodicity, are incorporated into a linear state-space model. In simulations, we show that in terms of signal-to-error ratio, the sources are inferred more accurately as a result of the inclusion of strong prior knowledge. We explore different schemes of maximum-likelihood optimization for the purpose of learning the model parameters. The Expectation Maximization algorithm, which is often considered the standard optimization method in this context, results in slow convergence when the noise variance is small. In such scenarios, quasi-Newton optimization yields substantial improvements in a range of signal to noise ratios. We analyze the performance of the methods on convolutive mixtures of speech signals. [abs] [ pdf ][ bib ] &copy JMLR 2006. ( edit, beta )

YNIMG Journal 2006 Journal Article

Parallel Factor Analysis as an exploratory tool for wavelet transformed event-related EEG

  • Morten Mørup
  • Lars Kai Hansen
  • Christoph S. Herrmann
  • Josef Parnas
  • Sidse M. Arnfred

In the decomposition of multi-channel EEG signals, principal component analysis (PCA) and independent component analysis (ICA) have widely been used. However, as both methods are based on handling two-way data, i. e. two-dimensional matrices, multi-way methods might improve the interpretation of frequency transformed multi-channel EEG of channel × frequency × time data. The multi-way decomposition method Parallel Factor (PARAFAC), also named Canonical Decomposition (CANDECOMP), was recently used to decompose the wavelet transformed ongoing EEG of channel × frequency × time (Miwakeichi, F. , Martinez-Montes, E. , Valdes-Sosa, P. A. , Nishiyama, N. , Mizuhara, H. , Yamaguchi, Y. , 2004. Decomposing EEG data into space–time–frequency components using parallel factor analysis. Neuroimage 22, 1035–1045). In this article, PARAFAC is used for the first time to decompose wavelet transformed event-related EEG given by the inter-trial phase coherence (ITPC) encompassing ANOVA analysis of differences between conditions and 5-way analysis of channel × frequency × time × subject × condition. A flow chart is presented on how to perform data exploration using the PARAFAC decomposition on multi-way arrays. This includes (A) channel × frequency × time 3-way arrays of F test values from a repeated measures analysis of variance (ANOVA) between two stimulus conditions; (B) subject-specific 3-way analyses; and (C) an overall 5-way analysis of channel × frequency × time × subject × condition. The PARAFAC decompositions were able to extract the expected features of a previously reported ERP paradigm: namely, a quantitative difference of coherent occipital gamma activity between conditions of a visual paradigm. Furthermore, the method revealed a qualitative difference which has not previously been reported. The PARAFAC decomposition of the 3-way array of ANOVA F test values clearly showed the difference of regions of interest across modalities, while the 5-way analysis enabled visualization of both quantitative and qualitative differences. Consequently, PARAFAC is a promising data exploratory tool in the analysis of the wavelets transformed event-related EEG.

YNIMG Journal 2005 Journal Article

Mining the posterior cingulate: Segregation between memory and pain components

  • Finn Årup Nielsen
  • Daniela Balslev
  • Lars Kai Hansen

We present a general method for automatic meta-analyses in neuroscience and apply it on text data from published functional imaging studies to extract main functions associated with a brain area—the posterior cingulate cortex (PCC). Abstracts from PubMed are downloaded, words extracted and converted to a bag-of-words matrix representation. The combined data are analyzed with hierarchical non-negative matrix factorization. We find that the prominent themes in the PCC corpus are episodic memory retrieval and pain. We further characterize the distribution in PCC of the Talairach coordinates available in some of the articles. This shows a tendency to functional segregation between memory and pain components where memory activations are predominantly in the caudal part and pain in the rostral part of PCC.

AIIM Journal 2004 Journal Article

Finding related functional neuroimaging volumes

  • Finn Årup Nielsen
  • Lars Kai Hansen

We describe a content-based image retrieval technique for finding related functional neuroimaging experiments by voxelization of sets of stereotactic coordinates in Talairach space, comparing the volumes and reporting related volumes in a sorted list. Voxelization is accomplished by convolving each coordinate with a Gaussian kernel. The scheme allows us to compare experiments represented as either lists of coordinates or volumes, and we introduce alternative entrances to databases by image-based indices constructed via novelty measures and singular value decomposition.

YNIMG Journal 2004 Journal Article

Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics: I. A preliminary group analysis

  • Stephen Strother
  • Stephen La Conte
  • Lars Kai Hansen
  • Jon Anderson
  • Jin Zhang
  • Sujit Pulapura
  • David Rottenberg

We argue that published results demonstrate that new insights into human brain function may be obscured by poor and/or limited choices in the data-processing pipeline, and review the work on performance metrics for optimizing pipelines: prediction, reproducibility, and related empirical Receiver Operating Characteristic (ROC) curve metrics. Using the NPAIRS split-half resampling framework for estimating prediction/reproducibility metrics (Strother et al. , 2002), we illustrate its use by testing the relative importance of selected pipeline components (interpolation, in-plane spatial smoothing, temporal detrending, and between-subject alignment) in a group analysis of BOLD-fMRI scans from 16 subjects performing a block-design, parametric-static-force task. Large-scale brain networks were detected using a multivariate linear discriminant analysis (canonical variates analysis, CVA) that was tuned to fit the data. We found that tuning the CVA model and spatial smoothing were the most important processing parameters. Temporal detrending was essential to remove low-frequency, reproducing time trends; the number of cosine basis functions for detrending was optimized by assuming that separate epochs of baseline scans have constant, equal means, and this assumption was assessed with prediction metrics. Higher-order polynomial warps compared to affine alignment had only a minor impact on the performance metrics. We found that both prediction and reproducibility metrics were required for optimizing the pipeline and give somewhat different results. Moreover, the parameter settings of components in the pipeline interact so that the current practice of reporting the optimization of components tested in relative isolation is unlikely to lead to fully optimized processing pipelines.

YNIMG Journal 2003 Journal Article

The Evaluation of Preprocessing Choices in Single-Subject BOLD fMRI Using NPAIRS Performance Metrics

  • Stephen LaConte
  • Jon Anderson
  • Suraj Muley
  • James Ashe
  • Sally Frutiger
  • Kelly Rehm
  • Lars Kai Hansen
  • Essa Yacoub

This work proposes an alternative to simulation-based receiver operating characteristic (ROC) analysis for assessment of fMRI data analysis methodologies. Specifically, we apply the rapidly developing nonparametric prediction, activation, influence, and reproducibility resampling (NPAIRS) framework to obtain cross-validation-based model performance estimates of prediction accuracy and global reproducibility for various degrees of model complexity. We rely on the concept of an analysis chain meta-model in which all parameters of the preprocessing steps along with the final statistical model are treated as estimated model parameters. Our ROC analog, then, consists of plotting prediction vs. reproducibility results as curves of model complexity for competing meta-models. Two theoretical underpinnings are crucial to utilizing this new validation technique. First, we explore the relationship between global signal-to-noise and our reproducibility estimates as derived previously. Second, we submit our model complexity curves in the prediction versus reproducibility space as reflecting classic bias-variance tradeoffs. Among the particular analysis chains considered, we found little impact in performance metrics with alignment, some benefit with temporal detrending, and greatest improvement with spatial smoothing.

AIIM Journal 2002 Journal Article

Exploring fMRI data for periodic signal components

  • Lars Kai Hansen
  • Finn Årup Nielsen
  • Jan Larsen

We use a Bayesian framework to detect periodic components in fMRI data. The resulting detector is sensitive to periodic components with a flexible number of harmonics and with arbitrary amplitude and phases of the harmonics. It is possible to detect the correct number of harmonics in periodic signals even if the fundamental frequency is beyond the Nyquist frequency. We apply the signal detector to locate regions that are highly affected by periodic physiological artifacts, such as cardiac pulsation.

YNIMG Journal 2002 Journal Article

The Quantitative Evaluation of Functional Neuroimaging Experiments: The NPAIRS Data Analysis Framework

  • Stephen C. Strother
  • Jon Anderson
  • Lars Kai Hansen
  • Ulrik Kjems
  • Rafal Kustra
  • John Sidtis
  • Sally Frutiger
  • Suraj Muley

We introduce a data-analysis framework and performance metrics for evaluating and optimizing the interaction between activation tasks, experimental designs, and the methodological choices and tools for data acquisition, preprocessing, data analysis, and extraction of statistical parametric maps (SPMs). Our NPAIRS (nonparametric prediction, activation, influence, and reproducibility resampling) framework provides an alternative to simulations and ROC curves by using real PET and fMRI data sets to examine the relationship between prediction accuracy and the signal-to-noise ratios (SNRs) associated with reproducible SPMs. Using cross-validation resampling we plot training–test set predictions of the experimental design variables (e. g. , brain-state labels) versus reproducibility SNR metrics for the associated SPMs. We demonstrate the utility of this framework across the wide range of performance metrics obtained from [15O]water PET studies of 12 age- and sex-matched data sets performing different motor tasks (8 subjects/set). For the 12 data sets we apply NPAIRS with both univariate and multivariate data-analysis approaches to: (1) demonstrate that this framework may be used to obtain reproducible SPMs from any data-analysis approach on a common Z-score scale (rSPM{Z}); (2) demonstrate that the histogram of a rSPM{Z} image may be modeled as the sum of a data-analysis-dependent noise distribution and a task-dependent, Gaussian signal distribution that scales monotonically with our reproducibility performance metric; (3) explore the relation between prediction and reproducibility performance metrics with an emphasis on bias-variance tradeoffs for flexible, multivariate models; and (4) measure the broad range of reproducibility SNRs and the significant influence of individual subjects. A companion paper describes learning curves for four of these 12 data sets, which describe an alternative mutual-information prediction metric and NPAIRS reproducibility as a function of training-set sizes from 2 to 18 subjects. We propose the NPAIRS framework as a validation tool for testing and optimizing methodological choices and tools in functional neuroimaging.

YNIMG Journal 2001 Journal Article

Consensus Inference in Neuroimaging

  • Lars Kai Hansen
  • Finn Årup Nielsen
  • Stephen C. Strother
  • Nicholas Lange

We introduce model averaging in neuroimaging. We show that model summary images can be directly compared and averaged after histogram equalization. We demonstrate that averaging enhances the ROC curve in a simulation study. The averaging procedure is applied to a fMRI study of motor cortex.

YNIMG Journal 1999 Journal Article

Generalizable Patterns in Neuroimaging: How Many Principal Components?

  • Lars Kai Hansen
  • Jan Larsen
  • Finn Årup Nielsen
  • Stephen C. Strother
  • Egill Rostrup
  • Robert Savoy
  • Nicholas Lange
  • John Sidtis

Generalization can be defined quantitatively and can be used to assess the performance of principal component analysis (PCA). The generalizability of PCA depends on the number of principal components retained in the analysis. We provide analytic and test set estimates of generalization. We show how the generalization error can be used to select the number of principal components in two analyses of functional magnetic resonance imaging activation sets.

YNIMG Journal 1999 Journal Article

On Clustering fMRI Time Series

  • Cyril Goutte
  • Peter Toft
  • Egill Rostrup
  • Finn Å. Nielsen
  • Lars Kai Hansen

Analysis of fMRI time series is often performed by extracting one or more parameters for the individual voxels. Methods based, e. g. , on various statistical tests are then used to yield parameters corresponding to probability of activation or activation strength. However, these methods do not indicate whether sets of voxels are activated in a similar way or in different ways. Typically, delays between two activated signals are not identified. In this article, we use clustering methods to detect similarities in activation between voxels. We employ a novel metric that measures the similarity between the activation stimulus and the fMRI signal. We present two different clustering algorithms and use them to identify regions of similar activations in an fMRI experiment involving a visual stimulus.

YNIMG Journal 1999 Journal Article

Plurality and Resemblance in fMRI Data Analysis

  • Nicholas Lange
  • Stephen C. Strother
  • Jon R. Anderson
  • Finn Å. Nielsen
  • Andrew P. Holmes
  • Thomas Kolenda
  • Robert Savoy
  • Lars Kai Hansen

We apply nine analytic methods employed currently in imaging neuroscience to simulated and actual BOLD fMRI signals and compare their performances under each signal type. Starting with baseline time series generated by a resting subject during a null hypothesis study, we compare method performance with embedded focal activity in these series of three different types whose magnitudes and time courses are simple, convolved with spatially varying hemodynamic responses, and highly spatially interactive. We then apply these same nine methods to BOLD fMRI time series from contralateral primary motor cortex and ipsilateral cerebellum collected during a sequential finger opposition study. Paired comparisons of results across methods include a voxel-specific concordance correlation coefficient for reproducibility and a resemblance measure that accommodates spatial autocorrelation of differences in activity surfaces. Receiver-operating characteristic curves show considerable model differences in ranges less than 10% significance level (false positives) and greater than 80% power (true positives). Concordance and resemblance measures reveal significant differences between activity surfaces in both data sets. These measures can assist researchers by identifying groups of models producing similar and dissimilar results, and thereby help to validate, consolidate, and simplify reports of statistical findings. A pluralistic strategy for fMRI data analysis can uncover invariant and highly interactive relationships between local activity foci and serve as a basis for further discovery of organizational principles of the brain. Results also suggest that a pluralistic empirical strategy coupled formally with substantive prior knowledge can help to uncover new brain–behavior relationships that may remain hidden if only a single method is employed.

v2026.09.13