Author name cluster

Jun Sung Kim

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

4 papers

1 author row

YNICL Journal 2025 Journal Article

Unraveling SNAP: distinct patterns of early neurodegeneration through MRI texture analysis

Min Jeong Kwon
Jieun Park
Sungman Jo
Jun Sung Kim
Hyukjun Lee
Dae Jong Oh
Ji Won Han
Ki Woong Kim

AIM: Suspected non-Alzheimer's disease pathophysiology (SNAP) is a condition characterized by neurodegeneration in the absence of amyloid beta (Aβ) deposition, posing challenges for early diagnosis. This study aimed to investigate the progression of neurodegeneration in SNAP through the analysis of brain MRI volume and texture. METHODS: The study included 449 amyloid-negative participants categorized into three groups: cognitively normal without neurodegeneration (N-CN), cognitively normal with neurodegeneration (N + CN), and MCI with neurodegeneration (N + MCI). Volume and texture metrics were derived from T1-weighted MRI. Texture analysis quantified microstructural changes using grey level co-occurrence matrices, while volume metrics measured atrophy. RESULTS: Texture changes were observed earlier and more widely than volume reductions. In N + CN, texture changes were present in the hippocampus, entorhinal cortex and orbitofrontal cortex. In N + MCI, texture changes extended to frontal and subcortical regions, including the thalamus and putamen, while volume reductions extended to the lateral temporal cortex and amygdala. CONCLUSIONS: Texture analysis is a sensitive tool for detecting early neurodegenerative changes in SNAP, capturing microstructural changes preceding volume loss. By integrating texture and volume metrics, this study highlights a distinct neurodegenerative trajectory in SNAP. Future research should validate these findings longitudinally and explore the clinical application of texture metrics.

Details DOI

YNIMG Journal 2024 Journal Article

Effects of sleep quality on diurnal variation of brain volume in older adults: A retrospective cross-sectional study

Jun Sung Kim
Ji Won Han
Dae Jong Oh
Seung Wan Suh
Min Jeong Kwon
Jieun Park
Sungman Jo
Jae Hyoung Kim

AIM: Brain volume is influenced by several factors that can change throughout the day. In addition, most of these factors are influenced by sleep quality. This study investigated diurnal variation in brain volume and its relation to overnight sleep quality. METHODS: ). RESULTS: groups only in the individuals with good sleep quality. CONCLUSION: Human brain volume changes significantly within a day associated with overnight sleep in the individuals with good sleep quality.

Details DOI

YNICL Journal 2023 Journal Article

Association of estimated white matter hyperintensity age with cognition in elderly with controlled hypertension

Jun Sung Kim
Jong Bin Bae
Ji Won Han
Dae Jong Oh
Seung Wan Suh
Jae Hyoung Kim
Ki Woong Kim

INTRODUCTION: Hypertension is associated with white matter hyperintensity (WMH) and cognitive impairment. Further, WMH is associated with cognitive impairment including executive, attention and visuospatial functions. The aim of this study was to investigate the effects of controlled hypertension (cHT) and previously developed concept, 'WMH age' on cognitive function and the mediating role of WMH in the effect of cHT on cognitive impairment. METHODS: We enrolled 855 Koreans without dementia aged 60 years or older, 326 of whom completed 2-year follow-up assessment. We measured their blood pressure thrice in a sitting position using an automated blood pressure monitoring device. We estimated 'WMH age' of every participant using previously developed WMH probability map of healthy older Koreans. We analyzed the mediating effect of WMH age in the association of cHT and cognitive function using the PROCESS Macro model. RESULTS: Old WMH age was associated with a faster decline in the Mini-Mental Status Examination (MMSE; p =.003), Consortium to Establish a Registry for Alzheimer's Disease total score (CERAD-TS; p =.003), and Frontal Assessment Battery (FAB; p =.007). Old WMH age showed an approximately-six times higher risk of incident mild cognitive impairment (OR = 6.47, 95 % CI = 1.37 - 9.50, p =.024) compared to young or normal WMH age over the 2-year follow-up period in the cHT group. WMH age mediated the effects of cHT on the MMSE, CERAD-TS, and FAB scores at baseline and two-year follow-up period. CONCLUSIONS: WMH mediates the adverse effect of hypertension on cognitive function. Elders with cHT who have older WMH age may be at a higher risk of cognitive decline.

Details DOI

YNICL Journal 2021 Journal Article

Construction and validation of a cerebral white matter hyperintensity probability map of older Koreans

Jun Sung Kim
Subin Lee
Grace Eun Kim
Dae Jong Oh
Woori Moon
Jong Bin Bae
Ji Won Han
Seonjeong Byun

BACKGROUND AND PURPOSE: Although two white matter hyperintensity (WMH) probability maps of healthy older adults already exist, they have several limitations in representing the distribution of WMH in healthy older adults, especially Asian older adults. We constructed and validated a WMH probability map (WPM) of healthy older Koreans and examined the age-associated differences of WMH. METHODS: We constructed WPM using development dataset that consisted of high-resolution 3D fluid-attenuated inversion recovery images of 5 age groups (60-64 years, 65-69 years, 70-74 years, 75-79 years, and 80+ years). Each age group included 30 age-matched men and women each. We tested the validity of the WPM by comparing WMH ages estimated by the WPM and the chronological ages of 30 healthy controls, 30 hypertension patients, and 30 S patients. RESULTS: Older age groups showed a higher volume of WMH in both hemispheres (p < 0.001). About 90% of the WMH were periventricular in all age groups. With advancing age, the peak of the distance histogram from the ventricular wall of the periventricular WMH shifted away from the ventricular wall, while that of deep WMH shifted toward the ventricular wall. The estimated WMH ages were comparable to the chronological ages in the healthy controls, while being higher than the chronological ages in hypertension and stroke patients. CONCLUSIONS: This WPM may serve as a standard atlas in research on WMH of older adults, especially Asians.

Details DOI