YNICL Journal 2025 Journal Article
Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease
- John McFadden
- Julian Matthews
- Lauren Scott
- Karl Herholz
- Ben Dickie
- Hamied Haroon
- Oliver Sparasci
- Saadat Ahmed
Highlights • Regional OEF, ATT, CBF, and CMRO2 were estimated in elderly people using MRI.• ATT was longer in those with more vascular risk and worse cognition.• OEF was elevated in those with longer ATT and lower CBF.