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Jingjing Zhou

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AAAI Conference 2026 Conference Paper

STaR: Sensitive Trajectory Regulation for Unlearning in Large Reasoning Models

  • Jingjing Zhou
  • Gaoxiang Cong
  • Li Su
  • Liang Li

Large Reasoning Models (LRMs) have advanced automated multi-step reasoning, but their ability to generate complex Chain-of-Thought (CoT) trajectories introduces severe privacy risks, as sensitive information may be deeply embedded throughout the reasoning process. Existing Large Language Models (LLMs) unlearning approaches that typically focus on modifying only final answers are insufficient for LRMs, as they fail to remove sensitive content from intermediate steps, leading to persistent privacy leakage and degraded security. To address these challenges, we propose Sensitive Trajectory Regulation (STaR), a parameter-free, inference-time unlearning framework that achieves robust privacy protection throughout the reasoning process. Specifically, we first identify sensitive content via semantic-aware detection. Then, we inject global safety constraints through secure prompt encoder. Next, we perform trajectory-aware suppression to dynamically block sensitive content across the entire reasoning chain. Finally, we apply token-level adaptive filtering to prevent both exact and paraphrased sensitive tokens during generation. Furthermore, to overcome the inadequacies of existing evaluation protocols, we introduce two metrics: Multi-Decoding Consistency Assessment (MCS), which measures the consistency of unlearning across diverse decoding strategies, and Multi-Granularity Membership Inference Attack (MIA) Evaluation, which quantifies privacy protection at both answer and reasoning-chain levels. Experiments on the R-TOFU benchmark demonstrate that STaR achieves comprehensive and stable unlearning with minimal utility loss, setting a new standard for privacy-preserving reasoning in LRMs.

TIST Journal 2025 Journal Article

Joint Structural-Functional Brain Graph Transformer

  • Ciyuan Peng
  • Huafei Huang
  • Tianqi Guo
  • Chengxuan Meng
  • Jingjing Zhou
  • Wenhong Zhao
  • Ruwan Tennakoon
  • Feng Xia

Multimodal brain graph transformers have become one of the foundational architectures of graph foundation models for brain science, relying on multimodal brain network fusion. However, most current multimodal brain network fusion methods primarily focus on modality-specific information fusion. The interplays within structural-functional brain networks are often ignored. Therefore, they fail to acquire essential coupling information, which is crucial for obtaining robust joint brain network representations. This oversight inevitably limits the effectiveness and generalization of these representations in various downstream tasks. To this end, we propose a novel joint structural-functional brain graph transformer model (namely sfBGT). Technically, we design a cross-network assortativity quantification mechanism to enable structural-functional brain network coupling, thus capturing the interplays of brain structure and function. We then employ a multimodal graph transformer to effectively learn joint representations of structural-functional brain networks along with their coupling relation representations. Experimental results on three real-world datasets demonstrate the superiority of sfBGT over state-of-the-art baselines.

YNICL Journal 2025 Journal Article

Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder

  • Yun Wang
  • Jingjing Zhou
  • Xiongying Chen
  • Rui Liu
  • Zhifang Zhang
  • Yuan Feng
  • Yuan Zhou
  • Gang Wang

The nucleus accumbens (NAc) plays a crucial role in the pathophysiology of major depressive disorder (MDD), and abnormal resting-state functional connectivity (rsFC) of NAc subregions has been found in MDD. However, it is unclear whether the altered rsFC of NAc subregions can predict the efficacy of antidepressant treatment, and whether antidepressants are capable of restoring the altered rsFC of NAc subregions in MDD. The purpose of this study was to investigate the role of rsFC of the NAc subregions in antidepressant treatment for MDD. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 46 unmedicated MDD patients at baseline and after 12 weeks of escitalopram treatment, along with fMRI data from 58 healthy controls (HCs). We examined group differences in rsFC of the NAc subregions between MDD patients and HCs, explored whether the altered rsFC at baseline was associated with treatment efficacy, and evaluated whether antidepressant treatment could normalize rsFC abnormalities in the NAc subregions in MDD. Compared to HCs, MDD patients exhibited decreased rsFC between the NAc subregions and the middle cingulate cortex (MCC). Lower levels of rsFC between the NAc subregions and the MCC at baseline predicted greater improvement in depressive symptoms. Furthermore, rsFC between the NAc subregions and the MCC increased following antidepressant treatment in MDD. Our findings suggest that rsFC alterations between the NAc subregions and the MCC may serve as a potential biomarker for predicting antidepressant treatment efficacy, and that dysfunction in the frontal-ventral striatum circuitry may represent a key therapeutic target for MDD.

v2026.09.13